ES444834A1 - Procedure for the preparation of semicarbazides. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of semicarbazides. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES444834A1 ES444834A1 ES444834A ES444834A ES444834A1 ES 444834 A1 ES444834 A1 ES 444834A1 ES 444834 A ES444834 A ES 444834A ES 444834 A ES444834 A ES 444834A ES 444834 A1 ES444834 A1 ES 444834A1
- Authority
- ES
- Spain
- Prior art keywords
- benzenesulfonyl
- formula
- radical
- substituted
- see formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Procedure for the preparation of semicarbazides of the formula **(See formula)** where X signifies bidrogen, chlorine, bromine, methyl or methoxy, Y signifies -CH (CH3) -CH2, -, preferably -CH2-CH2-, Z signifies hydrogen or a hydrocarbon radical with 1 or 2 carbon atoms that forms with Y is a 5- or 6-membered anilium, and R means a) a 3 to 7 ring carbon quyleneimino radical that may be optionally unsaturated or substituted by 1 or 2 methyl groups or a lower alcohol group or a methoxy group, b) a pentamethylene imino radical substituted by an endoalkylene radical with 1 to 3 carbon atoms, c) a hexamethylene radical substituted by an endoethylene group in the beta-epsilon position, d) a radical trahydro-isoindoline, 4, 7-endoalkylenehexahydro- or tetrahydro-isoindoline, in which the endoalkylene group contains 1 or 2 carbon atoms and the double bond of the tetrahydroxy compound is in the 5,6 position, and its salts, characterized in that a) benzenesulfonamides are reacted with the formula **(See formula)** conveniently in the form of their salts, with imino-carbamic acid esters, iminothiol-carbamic acid esters or imino-ureas containing the group R- as imino radical, b) amines of the formula RNH2 or their salts are reacted with benzenesulfonyl-isocyanates, benzenesulfonyl-carbamic acid esters, benzenesulfonyl-thiolcarbamic acid esters, benzene sulfonyl-carbamic acid halides or benzenesulfonyl-ureas, substituted in position 3 by group Z and in position 4 by **(See formula)** c) benzenesulfochlorides of the formula are reacted **(See formula)** with R-substituted ureas, d) hydrolyze benzenesulfonyl-isoureas ethers, benzenesulfonyl-isothio-ureas ethers or benzenesulfonyl-imino-parabanic acid derivatives, substituted by R, Z and **(See formula)** or e) is substituted by benzenesulfonyl-thiourcas of the formula **(See formula)** the sulfur atom by an oxygen atom, or f) is introduced into benzenesulfonyl-ureas of the formula **(See formula)** eventually staggered, the radical **(See formula)** and the products according to the invention are optionally treated for the formation of salts with alkaline agents or with acceptable inorganic or organic acids: physiologically. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19702027950 DE2027950A1 (en) | 1970-06-06 | 1970-06-06 | Benzenesulfonylureas and process for their preparation |
| DE19712120266 DE2120266A1 (en) | 1971-04-26 | 1971-04-26 | Benzenesulfonyl semicarbazides and processes for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES444834A1 true ES444834A1 (en) | 1977-05-01 |
Family
ID=25759238
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES391792A Expired ES391792A1 (en) | 1970-06-06 | 1971-05-31 | Procedure for the preparation of bencenosulfonilureas. (Machine-translation by Google Translate, not legally binding) |
| ES418120A Expired ES418120A1 (en) | 1970-06-06 | 1973-08-22 | Procedure for the preparation of sulfonil-ureas. (Machine-translation by Google Translate, not legally binding) |
| ES444834A Expired ES444834A1 (en) | 1970-06-06 | 1976-01-31 | Procedure for the preparation of semicarbazides. (Machine-translation by Google Translate, not legally binding) |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES391792A Expired ES391792A1 (en) | 1970-06-06 | 1971-05-31 | Procedure for the preparation of bencenosulfonilureas. (Machine-translation by Google Translate, not legally binding) |
| ES418120A Expired ES418120A1 (en) | 1970-06-06 | 1973-08-22 | Procedure for the preparation of sulfonil-ureas. (Machine-translation by Google Translate, not legally binding) |
Country Status (15)
| Country | Link |
|---|---|
| BE (1) | BE768135A (en) |
| BG (1) | BG19796A3 (en) |
| CA (1) | CA986114A (en) |
| CH (12) | CH577974A5 (en) |
| DK (1) | DK138793C (en) |
| ES (3) | ES391792A1 (en) |
| FI (1) | FI50792C (en) |
| FR (1) | FR2100731A1 (en) |
| HU (1) | HU166708B (en) |
| IE (1) | IE35332B1 (en) |
| IL (1) | IL36983A (en) |
| IT (1) | IT1037032B (en) |
| NL (1) | NL7107502A (en) |
| RO (1) | RO58731A (en) |
| SE (1) | SE361038B (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1294957B (en) * | 1966-07-02 | 1969-05-14 | Boehringer & Soehne Gmbh | Process for the preparation of hydrindene sulphonylureas and sulphonyl semicarbazides |
-
1971
- 1971-05-31 ES ES391792A patent/ES391792A1/en not_active Expired
- 1971-06-01 NL NL7107502A patent/NL7107502A/xx unknown
- 1971-06-01 BG BG017705A patent/BG19796A3/en unknown
- 1971-06-03 IE IE719/71A patent/IE35332B1/en unknown
- 1971-06-03 FI FI711544A patent/FI50792C/en active
- 1971-06-03 RO RO70340A patent/RO58731A/ro unknown
- 1971-06-04 CH CH1021375A patent/CH577974A5/xx not_active IP Right Cessation
- 1971-06-04 CH CH1022175A patent/CH576971A5/xx not_active IP Right Cessation
- 1971-06-04 CH CH1021775A patent/CH586219A5/xx not_active IP Right Cessation
- 1971-06-04 CA CA114,786A patent/CA986114A/en not_active Expired
- 1971-06-04 CH CH1021575A patent/CH586203A5/xx not_active IP Right Cessation
- 1971-06-04 CH CH1021675A patent/CH577479A5/xx not_active IP Right Cessation
- 1971-06-04 CH CH815771A patent/CH568291A5/xx not_active IP Right Cessation
- 1971-06-04 IL IL36983A patent/IL36983A/en unknown
- 1971-06-04 CH CH1021875A patent/CH576972A5/xx not_active IP Right Cessation
- 1971-06-04 CH CH1022075A patent/CH576973A5/xx not_active IP Right Cessation
- 1971-06-04 CH CH1021275A patent/CH577478A5/xx not_active IP Right Cessation
- 1971-06-04 SE SE07223/71A patent/SE361038B/xx unknown
- 1971-06-04 DK DK273471A patent/DK138793C/en active
- 1971-06-04 HU HUHO1381A patent/HU166708B/hu unknown
- 1971-06-04 BE BE768135A patent/BE768135A/en unknown
- 1971-06-04 CH CH1021475A patent/CH576965A5/xx not_active IP Right Cessation
- 1971-06-04 IT IT25459/71A patent/IT1037032B/en active
- 1971-06-04 CH CH1021975A patent/CH577498A5/xx not_active IP Right Cessation
- 1971-06-07 FR FR7120494A patent/FR2100731A1/en active Granted
-
1973
- 1973-08-22 ES ES418120A patent/ES418120A1/en not_active Expired
-
1976
- 1976-01-31 ES ES444834A patent/ES444834A1/en not_active Expired
- 1976-03-25 CH CH815771A patent/CH580593A5/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CH568291A5 (en) | 1975-10-31 |
| CH576971A5 (en) | 1976-06-30 |
| IT1037032B (en) | 1979-11-10 |
| FR2100731A1 (en) | 1972-03-24 |
| DK138793C (en) | 1979-03-26 |
| IL36983A0 (en) | 1971-08-25 |
| CH577478A5 (en) | 1976-07-15 |
| BE768135A (en) | 1971-12-06 |
| CH577498A5 (en) | 1976-07-15 |
| FI50792B (en) | 1976-03-31 |
| CH586203A5 (en) | 1977-03-31 |
| HU166708B (en) | 1975-05-28 |
| RO58731A (en) | 1975-12-15 |
| CH586219A5 (en) | 1977-03-31 |
| BG19796A3 (en) | 1975-10-10 |
| CH580593A5 (en) | 1976-10-15 |
| IE35332L (en) | 1971-12-06 |
| CH576972A5 (en) | 1976-06-30 |
| FR2100731B1 (en) | 1974-09-06 |
| CA986114A (en) | 1976-03-23 |
| IE35332B1 (en) | 1976-01-21 |
| IL36983A (en) | 1976-03-31 |
| CH577974A5 (en) | 1976-07-30 |
| FI50792C (en) | 1976-07-12 |
| ES418120A1 (en) | 1976-09-01 |
| NL7107502A (en) | 1971-12-08 |
| ES391792A1 (en) | 1974-08-01 |
| CH576965A5 (en) | 1976-06-30 |
| CH576973A5 (en) | 1976-06-30 |
| DK138793B (en) | 1978-10-30 |
| SE361038B (en) | 1973-10-15 |
| CH577479A5 (en) | 1976-07-15 |
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