ES442154A1 - Un procedimiento para la preparacion de nuevos compuestos deacido 2-deutero-3-fluor-dl-alanina. - Google Patents
Un procedimiento para la preparacion de nuevos compuestos deacido 2-deutero-3-fluor-dl-alanina.Info
- Publication number
- ES442154A1 ES442154A1 ES442154A ES442154A ES442154A1 ES 442154 A1 ES442154 A1 ES 442154A1 ES 442154 A ES442154 A ES 442154A ES 442154 A ES442154 A ES 442154A ES 442154 A1 ES442154 A1 ES 442154A1
- Authority
- ES
- Spain
- Prior art keywords
- fluoro
- salts
- deutero
- alanine
- racemic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003839 salts Chemical class 0.000 title abstract 4
- UYTSRQMXRROFPU-MYSWAXPFSA-N (2r)-2-amino-2-deuterio-3-fluoropropanoic acid Chemical compound FC[C@@](N)([2H])C(O)=O UYTSRQMXRROFPU-MYSWAXPFSA-N 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- UYTSRQMXRROFPU-LIIDHCAMSA-N (2s)-2-amino-2-deuterio-3-fluoropropanoic acid Chemical compound FC[C@](N)([2H])C(O)=O UYTSRQMXRROFPU-LIIDHCAMSA-N 0.000 abstract 1
- OSYXANRNDYBMOU-UHFFFAOYSA-N 3-fluoro-2-iminopropanoic acid Chemical class OC(=O)C(=N)CF OSYXANRNDYBMOU-UHFFFAOYSA-N 0.000 abstract 1
- CXABZTLXNODUTD-UHFFFAOYSA-N 3-fluoropyruvic acid Chemical compound OC(=O)C(=O)CF CXABZTLXNODUTD-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 238000006268 reductive amination reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
- C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/522,185 US3972921A (en) | 1974-11-08 | 1974-11-08 | Synthesis of racemic 2-deutero-3-fluoro-alanine and its salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES442154A1 true ES442154A1 (es) | 1977-07-01 |
Family
ID=24079796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES442154A Expired ES442154A1 (es) | 1974-11-08 | 1975-10-28 | Un procedimiento para la preparacion de nuevos compuestos deacido 2-deutero-3-fluor-dl-alanina. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US3972921A (en, 2012) |
| JP (1) | JPS5926614B2 (en, 2012) |
| AR (1) | AR208722A1 (en, 2012) |
| AT (1) | AT344136B (en, 2012) |
| BE (1) | BE835358A (en, 2012) |
| CA (1) | CA1053697A (en, 2012) |
| CH (1) | CH622772A5 (en, 2012) |
| CS (1) | CS199501B2 (en, 2012) |
| DD (1) | DD125839A5 (en, 2012) |
| DE (1) | DE2550121C2 (en, 2012) |
| DK (1) | DK474375A (en, 2012) |
| ES (1) | ES442154A1 (en, 2012) |
| FI (1) | FI752919A7 (en, 2012) |
| FR (1) | FR2290418A1 (en, 2012) |
| GB (1) | GB1480886A (en, 2012) |
| HU (1) | HU172273B (en, 2012) |
| IE (1) | IE42060B1 (en, 2012) |
| IT (1) | IT1048054B (en, 2012) |
| LU (1) | LU73734A1 (en, 2012) |
| NL (1) | NL7512383A (en, 2012) |
| NO (1) | NO147671C (en, 2012) |
| PL (1) | PL102608B1 (en, 2012) |
| SE (1) | SE7511734L (en, 2012) |
| SU (1) | SU626689A3 (en, 2012) |
| YU (1) | YU39750B (en, 2012) |
| ZA (1) | ZA757012B (en, 2012) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4028405A (en) * | 1974-10-15 | 1977-06-07 | Merck & Co., Inc. | Fluorinated amino acids |
| US4049708A (en) * | 1976-03-04 | 1977-09-20 | Merck & Co., Inc. | Fluorodesulfurization of alkyl mercaptans or alkyl dithianes |
| NZ194348A (en) * | 1979-07-26 | 1982-09-14 | Merrell Toraude & Co | Fluorinated methyl-beta-alanine derivatives and pharmaceutical compositions |
| JPS56113733A (en) * | 1979-12-29 | 1981-09-07 | Daikin Ind Ltd | 3-substituted-3-fluoropyruvic acid, its ester, salt and preparation thereof |
| US4582931A (en) * | 1984-12-24 | 1986-04-15 | Merck & Co., Inc. | Preparation of 2-Deutero-D-serine |
| US5254730A (en) * | 1992-01-14 | 1993-10-19 | Kilgore James L | Production of amino acids and amino acid derivatives bearing isotopic hydrogen labels |
| FR2707309B1 (fr) * | 1993-07-09 | 1995-08-11 | Trefileurope France Sa | Câble de levage. |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2610212A (en) * | 1950-04-24 | 1952-09-09 | Gen Mills Inc | Synthesis of amino acids |
| US2839547A (en) * | 1955-07-30 | 1958-06-17 | Inventa Ag | Process for the production of aminocarboxylic acids |
| JPS4936389B1 (en, 2012) * | 1969-03-03 | 1974-09-30 | ||
| US3585361A (en) * | 1969-06-18 | 1971-06-15 | Nordson Corp | Supply system for heating and dispensing molten thermoplastic material |
| JPS4841007B1 (en, 2012) * | 1970-10-22 | 1973-12-04 | ||
| JPS5225415B2 (en, 2012) * | 1972-01-17 | 1977-07-07 | ||
| JPS4935435A (en, 2012) * | 1972-08-09 | 1974-04-02 |
-
1974
- 1974-11-08 US US05/522,185 patent/US3972921A/en not_active Expired - Lifetime
-
1975
- 1975-10-20 SE SE7511734A patent/SE7511734L/xx unknown
- 1975-10-20 FI FI752919A patent/FI752919A7/fi not_active Application Discontinuation
- 1975-10-22 NL NL7512383A patent/NL7512383A/xx not_active Application Discontinuation
- 1975-10-22 DK DK474375A patent/DK474375A/da not_active Application Discontinuation
- 1975-10-23 NO NO753561A patent/NO147671C/no unknown
- 1975-10-27 YU YU2722/75A patent/YU39750B/xx unknown
- 1975-10-27 CA CA238,618A patent/CA1053697A/en not_active Expired
- 1975-10-27 GB GB44182/75A patent/GB1480886A/en not_active Expired
- 1975-10-28 ES ES442154A patent/ES442154A1/es not_active Expired
- 1975-10-28 AR AR260981A patent/AR208722A1/es active
- 1975-10-31 IT IT52036/75A patent/IT1048054B/it active
- 1975-10-31 SU SU752185056A patent/SU626689A3/ru active
- 1975-10-31 HU HU75ME00001914A patent/HU172273B/hu unknown
- 1975-11-04 CS CS757421A patent/CS199501B2/cs unknown
- 1975-11-04 AT AT838775A patent/AT344136B/de not_active IP Right Cessation
- 1975-11-05 FR FR7533779A patent/FR2290418A1/fr active Granted
- 1975-11-05 IE IE2407/75A patent/IE42060B1/en unknown
- 1975-11-05 DD DD189260A patent/DD125839A5/xx unknown
- 1975-11-06 PL PL1975184521A patent/PL102608B1/pl unknown
- 1975-11-06 LU LU73734A patent/LU73734A1/xx unknown
- 1975-11-06 CH CH1435875A patent/CH622772A5/de not_active IP Right Cessation
- 1975-11-07 DE DE2550121A patent/DE2550121C2/de not_active Expired
- 1975-11-07 JP JP50133150A patent/JPS5926614B2/ja not_active Expired
- 1975-11-07 BE BE161682A patent/BE835358A/xx not_active IP Right Cessation
- 1975-11-07 ZA ZA757012A patent/ZA757012B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL7512383A (nl) | 1976-05-11 |
| CH622772A5 (en, 2012) | 1981-04-30 |
| IE42060L (en) | 1976-05-08 |
| AT344136B (de) | 1978-07-10 |
| FI752919A7 (en, 2012) | 1976-05-09 |
| FR2290418B1 (en, 2012) | 1979-01-05 |
| DD125839A5 (en, 2012) | 1977-05-25 |
| YU39750B (en) | 1985-04-30 |
| NO753561L (en, 2012) | 1976-05-11 |
| SU626689A3 (ru) | 1978-09-30 |
| NO147671B (no) | 1983-02-14 |
| DK474375A (da) | 1976-05-09 |
| BE835358A (fr) | 1976-05-07 |
| GB1480886A (en) | 1977-07-27 |
| CA1053697A (en) | 1979-05-01 |
| IT1048054B (it) | 1980-11-20 |
| FR2290418A1 (fr) | 1976-06-04 |
| CS199501B2 (en) | 1980-07-31 |
| ATA838775A (de) | 1977-11-15 |
| JPS5170722A (en) | 1976-06-18 |
| DE2550121A1 (de) | 1976-05-20 |
| LU73734A1 (en, 2012) | 1976-09-06 |
| US3972921A (en) | 1976-08-03 |
| PL102608B1 (pl) | 1979-04-30 |
| JPS5926614B2 (ja) | 1984-06-29 |
| AR208722A1 (es) | 1977-02-28 |
| IE42060B1 (en) | 1980-05-21 |
| HU172273B (hu) | 1978-07-28 |
| ZA757012B (en) | 1977-06-29 |
| NO147671C (no) | 1983-05-25 |
| AU8605675A (en) | 1977-05-05 |
| SE7511734L (sv) | 1976-05-10 |
| DE2550121C2 (de) | 1984-08-16 |
| YU272275A (en) | 1982-02-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES446737A1 (es) | Procedimiento para la preparacion de nuevos derivados de critomicina. | |
| UA6301A1 (uk) | Спосіб одержання похідних ціс-4-феніл-1,2,3,4-тетрагідра-1-нафтіламіна або його солей | |
| ES445250A1 (es) | Un procedimiento para halogenar productos intermedios para la obtencion de anillos de cefem. | |
| YU159475A (en) | Process for obtaining new benzimidazoline derivatives | |
| HU170778B (hu) | Fungicidnye kompozicii i sposob poluchenija proizvodnykh l-propil-imidazola i soli, to est' soedinenijj primenimykh aktivnymi agentami | |
| ES436313A1 (es) | Procedimiento para la preparacion de nuevos 1-ariloxi-2-hi- droxi-3-alquinilaminopropanos. | |
| ES434533A1 (es) | Un procedimiento para la preparacion de compuestos tetraci-clicos. | |
| ES442154A1 (es) | Un procedimiento para la preparacion de nuevos compuestos deacido 2-deutero-3-fluor-dl-alanina. | |
| ES375933A1 (es) | Un metodo de preparar un compuesto de 2-amino-4-hidroxi-6- hidroximetil-7, 7 - dimetil - 7,8 - dihidropteridinao una forma tautomera de la misma. | |
| ES420922A1 (es) | Procedimiento para la preparacion de 2beta,16beta-diamino-5alfa-androstanos no sustituidos en la posicion 17. | |
| ES447664A1 (es) | Procedimiento de preparacion de derivados de cardenolidas. | |
| ES440046A1 (es) | Un procedimiento para la preparacion del antibiotico xk-62- 2. | |
| ES468127A1 (es) | Un procedimiento para la preparacion de nuevos derivados de pirido (2,1-b) quinazolina | |
| ES405479A1 (es) | Un procedimiento para la preparacion de derivados de benzo-diacepina. | |
| ES417396A1 (es) | Un procedimiento para la produccion de una composicion far-maceutica. | |
| SE7708686L (sv) | Mellanprodukter och forfarande for framstellning derav | |
| ES447176A1 (es) | Procedimiento para la preparacion de aminoacidos. | |
| ES454023A1 (es) | Procedimiento para la obtencion de una nueva forma cristali-na de sal sodica del cefacetrilo. | |
| GB1461068A (en) | Preparation of a sulphur-containing pyridine derivative | |
| ES333664A1 (es) | Un procedimiento para la preparacion de agentes antibacterianos. | |
| RO84457B (ro) | Procedeu pentru prepararea unor derivati de acid 7-beta-aminooxazolilacetilamino-3-cefem-4-carboxilic | |
| ES454307A1 (es) | Procedimiento para la preparacion de nuevos derivados de ci-clopentano. | |
| ES449991A1 (es) | Procedimiento para la preparacion de derivados de acido 7 (alfaamino-omega-(2,3-metilenodioxifenil y acilamido) cefa- losporanico. | |
| GB1366554A (en) | Phenylalanine derivatives and a process for their preparation | |
| ES414616A1 (es) | Un metodo de producir acido alfa-amino-beta-hidroxibutanoi-co. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19980202 |