ES436398A1 - Procedimiento para la produccion de un preparado de insuli- na. - Google Patents

Info

Publication number

ES436398A1

ES436398A1 ES436398A ES436398A ES436398A1 ES 436398 A1 ES436398 A1 ES 436398A1 ES 436398 A ES436398 A ES 436398A ES 436398 A ES436398 A ES 436398A ES 436398 A1 ES436398 A1 ES 436398A1

Authority

ES

Spain

Prior art keywords

insulin

mcg

zinc

isotonia

preservative

Prior art date

1974-04-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Links

• Espacenet
• Global Dossier
• Discuss

• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 15
• 229940125396 insulin Drugs 0.000 title abstract 9
• 102000004877 Insulin Human genes 0.000 title abstract 6
• 108090001061 Insulin Proteins 0.000 title abstract 6
• 238000004519 manufacturing process Methods 0.000 title abstract 2
• 238000000034 method Methods 0.000 title abstract 2
• 238000002360 preparation method Methods 0.000 title abstract 2
• 230000003178 anti-diabetic effect Effects 0.000 title 1
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
• HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 3
• 239000011701 zinc Substances 0.000 abstract 3
• 229910052725 zinc Inorganic materials 0.000 abstract 3
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
• 239000013078 crystal Substances 0.000 abstract 2
• 239000003755 preservative agent Substances 0.000 abstract 2
• 230000002335 preservative effect Effects 0.000 abstract 2
• 239000007974 sodium acetate buffer Substances 0.000 abstract 2
• 235000002639 sodium chloride Nutrition 0.000 abstract 2
• 239000011780 sodium chloride Substances 0.000 abstract 2
• 239000007864 aqueous solution Substances 0.000 abstract 1
• 239000007900 aqueous suspension Substances 0.000 abstract 1
• 239000000243 solution Substances 0.000 abstract 1
• 239000000725 suspension Substances 0.000 abstract 1