ES436155A1 - 1-oxo-1h-6-substituted pyrimido-1,2-a-quinoline-2-carboxylic acids and derivatives thereof as antiallergy agents - Google Patents

1-oxo-1h-6-substituted pyrimido-1,2-a-quinoline-2-carboxylic acids and derivatives thereof as antiallergy agents

Info

Publication number
ES436155A1
ES436155A1 ES436155A ES436155A ES436155A1 ES 436155 A1 ES436155 A1 ES 436155A1 ES 436155 A ES436155 A ES 436155A ES 436155 A ES436155 A ES 436155A ES 436155 A1 ES436155 A1 ES 436155A1
Authority
ES
Spain
Prior art keywords
lower alkoxy
carbon atoms
formula
hydroxy
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES436155A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES436155A1 publication Critical patent/ES436155A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A procedure to prepare 1-oxo-1H-6-hydroxypyrimido (1,2-a) quinolin-2-carboxylic acids and their derivatives of formula: **(See formula)** wherein each of the R1, R2, R3 and R4 benzene substituents is hydrogen, lower alkoxy, carbo (lower alkoxy), fluorine, chlorine, bromine, lower alkyl, methylthio or methylsulfinyl; R2 and R3 when taken together are 1,3-butadienyl or alkylenedioxy of 1 to 2 carbon atoms; R5 is hydroxy, lower alkoxy or substituted hydroxy (lower alkoxy); R6 is chloro, bromo or OR'6 where OR'6 is lower alkoxy, alkenyloxy of 3 to 4 carbon atoms or alkynyloxy of 3 to 4 carbon atoms; and the pharmaceutically acceptable cationic salts of those compounds wherein R5 is hydroxy; characterized by cycling a compound of the formula: **(See formula)** wherein R1 to R4 and R6 are as defined above, which are prepared in situ or preformed at elevated temperatures in the presence or absence of an inert solvent; and when it is required to convert those compounds where R6 is chlorine or bromine into OR'6 as defined above by reaction with the appropriate alcohol in the presence of an acidic catalyst; and if it is desired to convert the compounds thus prepared into the corresponding acids, into other esters and salts of the acids by hydrolysis, transesterification and treatment with metal or ammonium hydroxides, respectively. (Machine-translation by Google Translate, not legally binding)
ES436155A 1974-04-01 1975-03-31 1-oxo-1h-6-substituted pyrimido-1,2-a-quinoline-2-carboxylic acids and derivatives thereof as antiallergy agents Expired ES436155A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45679774A 1974-04-01 1974-04-01
US54722775A 1975-02-05 1975-02-05
US55496675A 1975-03-03 1975-03-03

Publications (1)

Publication Number Publication Date
ES436155A1 true ES436155A1 (en) 1977-02-01

Family

ID=27412681

Family Applications (1)

Application Number Title Priority Date Filing Date
ES436155A Expired ES436155A1 (en) 1974-04-01 1975-03-31 1-oxo-1h-6-substituted pyrimido-1,2-a-quinoline-2-carboxylic acids and derivatives thereof as antiallergy agents

Country Status (14)

Country Link
JP (1) JPS5427360B2 (en)
CA (1) CA1033731A (en)
DD (1) DD119425A5 (en)
DE (1) DE2513930A1 (en)
DK (1) DK138743B (en)
ES (1) ES436155A1 (en)
FI (1) FI750891A (en)
FR (1) FR2265389B1 (en)
GB (1) GB1451423A (en)
IE (1) IE40893B1 (en)
IL (1) IL46864A0 (en)
LU (1) LU72184A1 (en)
NL (1) NL7503692A (en)
PH (1) PH10464A (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4075343A (en) * 1976-09-13 1978-02-21 Pfizer Inc. Anti-allergenic 5-alkoxyimidazo[1,2-A]quinoline-2-carboxylic acids and derivatives thereof
US4127720A (en) * 1977-09-21 1978-11-28 Bristol-Myers Company Pyrimido[2,1-a]isoquinoline derivatives having antiallergy activity
US4209620A (en) * 1978-06-19 1980-06-24 Bristol-Myers Company Substituted 3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives having antiallergy activity
US4472401A (en) * 1981-11-27 1984-09-18 Roussel Uclaf Pyrimido-quinoxalines having antiallergic properties
US4510143A (en) * 1982-02-17 1985-04-09 Roussel Uclaf Antiallergic pyrimido[1,2-a]quinoxalin-2-carboxylic acid derivatives
WO1997037999A1 (en) * 1996-04-04 1997-10-16 University Of Nebraska Board Of Regents Synthetic triple helix-forming compounds
US6989392B2 (en) 2002-06-18 2006-01-24 Abbott Laboratories 2-Aminoquinolines as melanin concentrating hormone receptor antagonists

Also Published As

Publication number Publication date
IE40893L (en) 1975-10-01
JPS5427360B2 (en) 1979-09-10
PH10464A (en) 1977-04-25
IL46864A0 (en) 1975-05-22
DE2513930A1 (en) 1975-10-02
IE40893B1 (en) 1979-09-12
DD119425A5 (en) 1976-04-20
CA1033731A (en) 1978-06-27
DK138743C (en) 1979-04-02
FR2265389A1 (en) 1975-10-24
FR2265389B1 (en) 1978-07-28
DK130475A (en) 1975-10-02
GB1451423A (en) 1976-10-06
DK138743B (en) 1978-10-23
FI750891A (en) 1975-10-02
NL7503692A (en) 1975-10-03
LU72184A1 (en) 1976-03-02
AU7937775A (en) 1976-09-23
JPS50140499A (en) 1975-11-11

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