ES473991A1 - A procedure for the preparation of new derivatives of acids 1-carba-2-penem-3-carboxilicos. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

A procedure for the preparation of new 1-carba-2-penem-3-carboxylic acid derivatives of formula: ** (Formula) ** and its pharmaceutically acceptable salts, esters and amides, where R1, R2, and R3 are selected independently between the group consisting of hydrogen and the following substituted and unsubstituted groups: C1-C10-alkyl, alkenyl-C2-alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkyl and cycloalkylalkyl radicals where the preceding cycloalkyl or cycloalkenyl radicals contain 3 to 6 carbon atoms and the alkyl or alkenyl radicals contain 1 to 6 carbon atoms, aryl 6 to 10 carbon atoms, aralkyl, aralkenyl and aralquinyl 6 to 10 ring carbon atoms and 1 to 6 chain carbon atoms, heteroaryl, heterocyclic, and heterocycloalkyl where the heterocyclic structure is monocyclic or bicyclic and contains 4 to 10 atoms of which one or more is selected swimming between oxygen, sulfur and nitrogen and where the alkyl radical of said heterocycles contains from 1 to 3 carbon atoms and where the substituent or substituents of the aforementioned radicals are selected from the group consisting of amino hydroxyl, alkoxyl of 1 to 6 atoms of carbon, mercapto, C1-C6-alkylthio, sulfamoyl, amidino, guanidino, nitro, chloro, bromo, fluoro, cyano and carboxyl; with the proviso that when one of the radicals R1 or R2 is hydrogen and the other is 1-hydroxyethyl, then R3 is not hydrogen. (Machine-translation by Google Translate, not legally binding)