ES434079A1 - Procedimiento para la obtencion de compuestos indolicos sus-tituidos. - Google Patents
Procedimiento para la obtencion de compuestos indolicos sus-tituidos.Info
- Publication number
- ES434079A1 ES434079A1 ES434079A ES434079A ES434079A1 ES 434079 A1 ES434079 A1 ES 434079A1 ES 434079 A ES434079 A ES 434079A ES 434079 A ES434079 A ES 434079A ES 434079 A1 ES434079 A1 ES 434079A1
- Authority
- ES
- Spain
- Prior art keywords
- substituted
- group
- indole
- residue
- aliphatic hydrocarbon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- INXMOYLZSTUBBF-UHFFFAOYSA-N 1h-indol-2-yl(pyridin-2-yl)methanone Chemical class C=1C2=CC=CC=C2NC=1C(=O)C1=CC=CC=N1 INXMOYLZSTUBBF-UHFFFAOYSA-N 0.000 title abstract 3
- 125000001931 aliphatic group Chemical group 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 150000003839 salts Chemical class 0.000 abstract 4
- -1 2-pyridylcarbonyl group Chemical group 0.000 abstract 3
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- VZOCNPKEHREDFD-UHFFFAOYSA-N [2-(1H-indol-2-yl)-1H-pyridin-2-yl]methanol Chemical compound N1C(=CC2=CC=CC=C12)C1(NC=CC=C1)CO VZOCNPKEHREDFD-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
- 150000002475 indoles Chemical group 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000000737 periodic effect Effects 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 125000005400 pyridylcarbonyl group Chemical group N1=C(C=CC=C1)C(=O)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH104774 | 1974-01-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES434079A1 true ES434079A1 (es) | 1977-03-01 |
Family
ID=4201215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES434079A Expired ES434079A1 (es) | 1974-01-25 | 1975-01-23 | Procedimiento para la obtencion de compuestos indolicos sus-tituidos. |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS50106969A (enExample) |
| AT (1) | ATA53175A (enExample) |
| AU (1) | AU7756375A (enExample) |
| BE (1) | BE824742A (enExample) |
| DE (1) | DE2501468A1 (enExample) |
| DK (1) | DK3375A (enExample) |
| ES (1) | ES434079A1 (enExample) |
| FR (1) | FR2258853B1 (enExample) |
| GB (1) | GB1472342A (enExample) |
| IE (1) | IE40368B1 (enExample) |
| IL (1) | IL46505A0 (enExample) |
| NL (1) | NL7500535A (enExample) |
| SE (1) | SE7500262L (enExample) |
| ZA (1) | ZA75522B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4999186A (en) * | 1986-06-27 | 1991-03-12 | The Procter & Gamble Company | Novel sunscreen agents, sunscreen compositions and methods for preventing sunburn |
| PL358877A1 (en) * | 2000-04-28 | 2004-08-23 | Baxter Healthcare Sa | 2-acyl indol derivatives and their use as anti-tumour agents |
| DE10152306A1 (de) * | 2001-10-26 | 2003-07-24 | Asta Medica Ag | 2-Acylindolderivate mit neuen therapeutisch wertvollen Eigenschaften |
| US20100298343A1 (en) * | 2007-10-05 | 2010-11-25 | John Howard Hutchinson | 5-lipoxygenase-activating protein (flap) inhibitors |
| EP2448938B9 (en) | 2009-06-29 | 2015-06-10 | Incyte Corporation | Pyrimidinones as pi3k inhibitors |
| WO2011075643A1 (en) | 2009-12-18 | 2011-06-23 | Incyte Corporation | Substituted heteroaryl fused derivatives as pi3k inhibitors |
| AR079529A1 (es) | 2009-12-18 | 2012-02-01 | Incyte Corp | Derivados arilo y heteroarilo sustituidos y fundidos como inhibidores de la pi3k |
| EP2558463A1 (en) | 2010-04-14 | 2013-02-20 | Incyte Corporation | Fused derivatives as i3 inhibitors |
| US9062055B2 (en) | 2010-06-21 | 2015-06-23 | Incyte Corporation | Fused pyrrole derivatives as PI3K inhibitors |
| TW201249844A (en) | 2010-12-20 | 2012-12-16 | Incyte Corp | N-(1-(substituted-phenyl)ethyl)-9H-purin-6-amines as PI3K inhibitors |
| WO2012125629A1 (en) | 2011-03-14 | 2012-09-20 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors |
| US9126948B2 (en) | 2011-03-25 | 2015-09-08 | Incyte Holdings Corporation | Pyrimidine-4,6-diamine derivatives as PI3K inhibitors |
| KR102030609B1 (ko) | 2011-09-02 | 2019-10-11 | 인사이트 홀딩스 코포레이션 | Ｐｉ３ｋ 억제제로서 헤테로시클릴아민 |
| AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
| WO2015191677A1 (en) | 2014-06-11 | 2015-12-17 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors |
| DK3831833T3 (da) | 2015-02-27 | 2022-11-14 | Incyte Holdings Corp | Fremgangsmåder til fremstillingen af en pi3k-inhibitor |
| WO2016183063A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Crystalline forms of a pi3k inhibitor |
| US9732097B2 (en) | 2015-05-11 | 2017-08-15 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
| CN119258070A (zh) | 2018-06-01 | 2025-01-07 | 因赛特公司 | 治疗pi3k相关病症的给药方案 |
-
1975
- 1975-01-08 DK DK3375*BA patent/DK3375A/da unknown
- 1975-01-10 SE SE7500262A patent/SE7500262L/xx unknown
- 1975-01-16 DE DE19752501468 patent/DE2501468A1/de active Pending
- 1975-01-16 NL NL7500535A patent/NL7500535A/xx unknown
- 1975-01-23 GB GB299475A patent/GB1472342A/en not_active Expired
- 1975-01-23 FR FR7502129A patent/FR2258853B1/fr not_active Expired
- 1975-01-23 AU AU77563/75A patent/AU7756375A/en not_active Expired
- 1975-01-23 ES ES434079A patent/ES434079A1/es not_active Expired
- 1975-01-24 ZA ZA00750522A patent/ZA75522B/xx unknown
- 1975-01-24 AT AT53175A patent/ATA53175A/de not_active IP Right Cessation
- 1975-01-24 BE BE152675A patent/BE824742A/xx unknown
- 1975-01-24 IL IL46505A patent/IL46505A0/xx unknown
- 1975-01-24 IE IE137/75A patent/IE40368B1/xx unknown
- 1975-01-25 JP JP50010179A patent/JPS50106969A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ATA53175A (de) | 1977-08-15 |
| FR2258853B1 (enExample) | 1978-06-30 |
| IE40368B1 (en) | 1979-05-09 |
| ZA75522B (en) | 1976-01-28 |
| SE7500262L (enExample) | 1975-07-28 |
| FR2258853A1 (enExample) | 1975-08-22 |
| IE40368L (en) | 1975-07-25 |
| BE824742A (fr) | 1975-07-24 |
| AU7756375A (en) | 1976-07-29 |
| GB1472342A (en) | 1977-05-04 |
| DE2501468A1 (de) | 1975-07-31 |
| IL46505A0 (en) | 1975-04-25 |
| NL7500535A (nl) | 1975-07-29 |
| JPS50106969A (enExample) | 1975-08-22 |
| DK3375A (enExample) | 1975-09-15 |
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