IE40368B1 - Derivatives of 2-(2-pyridylcarbonyl)-indole - Google Patents
Derivatives of 2-(2-pyridylcarbonyl)-indoleInfo
- Publication number
- IE40368B1 IE40368B1 IE137/75A IE13775A IE40368B1 IE 40368 B1 IE40368 B1 IE 40368B1 IE 137/75 A IE137/75 A IE 137/75A IE 13775 A IE13775 A IE 13775A IE 40368 B1 IE40368 B1 IE 40368B1
- Authority
- IE
- Ireland
- Prior art keywords
- indole
- prepared
- derivatives
- substituted
- picolyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1472342 Derivatives of 2-(2-picolyl)indole CIBA-GEIGY AG 23 Jan 1975 [25 Jan 1974] 2994/75 Heading C2C The invention comprises indoles-and their salts-which are substituted (a) in the 1-position by aliphatic hydrocarbyl (possibly aryl-substituted), and (b) in the 2-position by (possibly C 1-7 -alkyl substituted) picolinoyl or alphahydroxypicolyl, and optionally (c) in other ring positions. In examples, these compounds are prepared by (1) reducing the ketones to carbinols, or the reverse oxidation process, (2) converting substituent methoxy groups to OH, or (3) reacting together either (i) a 2-lithioindole with 2-formylpyridine or 2-picolinic acid, or (ii) a 2-lithiopyridine with the corresponding indole- 2-carboxylic acid (which reagents are themselves prepared by hydrolysis of the methyl or ethyl esters). The acids may react in the form of their Li salts. Starting materials otherwise prepared have the formula 2,5-MeNH(Cl)C 6 H 3 X, where X is CONHNH 2 , CONHNHO 2 SC 6 H 4 Me(-p) or CHO. Therapeutic compositions having fibrinolytic, thrombolytic and platelet aggregation inhibitive activity, comprise the above 2-(2-picolyl)indole derivatives, and may be administered orally or parenterally.
[GB1472342A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH104774 | 1974-01-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE40368L IE40368L (en) | 1975-07-25 |
| IE40368B1 true IE40368B1 (en) | 1979-05-09 |
Family
ID=4201215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE137/75A IE40368B1 (en) | 1974-01-25 | 1975-01-24 | Derivatives of 2-(2-pyridylcarbonyl)-indole |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS50106969A (en) |
| AT (1) | ATA53175A (en) |
| AU (1) | AU7756375A (en) |
| BE (1) | BE824742A (en) |
| DE (1) | DE2501468A1 (en) |
| DK (1) | DK3375A (en) |
| ES (1) | ES434079A1 (en) |
| FR (1) | FR2258853B1 (en) |
| GB (1) | GB1472342A (en) |
| IE (1) | IE40368B1 (en) |
| IL (1) | IL46505A0 (en) |
| NL (1) | NL7500535A (en) |
| SE (1) | SE7500262L (en) |
| ZA (1) | ZA75522B (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4999186A (en) * | 1986-06-27 | 1991-03-12 | The Procter & Gamble Company | Novel sunscreen agents, sunscreen compositions and methods for preventing sunburn |
| CN1286810C (en) * | 2000-04-28 | 2006-11-29 | 巴克斯特保健股份有限公司 | 2-acyl indol derivatives and their use as anti-tumour agents |
| DE10152306A1 (en) * | 2001-10-26 | 2003-07-24 | Asta Medica Ag | 2-acylindole derivatives with new therapeutically valuable properties |
| EP2207547A4 (en) * | 2007-10-05 | 2010-11-17 | Amira Pharmaceuticals Inc | 5-lipoxygenase-activating protein (flap) inhibitors |
| SI2448938T1 (en) | 2009-06-29 | 2014-08-29 | Incyte Corporation Experimental Station | Pyrimidinones as pi3k inhibitors |
| WO2011075643A1 (en) | 2009-12-18 | 2011-06-23 | Incyte Corporation | Substituted heteroaryl fused derivatives as pi3k inhibitors |
| AR079529A1 (en) | 2009-12-18 | 2012-02-01 | Incyte Corp | ARILO AND HETEROARILO DERIVATIVES REPLACED AND FOUNDED AS INHIBITORS OF THE PI3K |
| US9193721B2 (en) | 2010-04-14 | 2015-11-24 | Incyte Holdings Corporation | Fused derivatives as PI3Kδ inhibitors |
| WO2011163195A1 (en) | 2010-06-21 | 2011-12-29 | Incyte Corporation | Fused pyrrole derivatives as pi3k inhibitors |
| JP5961187B2 (en) | 2010-12-20 | 2016-08-02 | インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ | N- (1- (substituted phenyl) ethyl) -9H-purin-6-amine as a PI3K inhibitor |
| US9108984B2 (en) | 2011-03-14 | 2015-08-18 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors |
| WO2012135009A1 (en) | 2011-03-25 | 2012-10-04 | Incyte Corporation | Pyrimidine-4,6-diamine derivatives as pi3k inhibitors |
| CA2846652C (en) | 2011-09-02 | 2019-11-05 | Incyte Corporation | Heterocyclylamines as pi3k inhibitors |
| AR090548A1 (en) | 2012-04-02 | 2014-11-19 | Incyte Corp | BICYCLIC AZAHETEROCICLOBENCILAMINS AS PI3K INHIBITORS |
| WO2015191677A1 (en) | 2014-06-11 | 2015-12-17 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors |
| ES2843522T3 (en) | 2015-02-27 | 2021-07-19 | Incyte Corp | PI3K inhibitor salts and processes for their preparation |
| WO2016183063A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Crystalline forms of a pi3k inhibitor |
| WO2016183060A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
-
1975
- 1975-01-08 DK DK3375*BA patent/DK3375A/da unknown
- 1975-01-10 SE SE7500262A patent/SE7500262L/xx unknown
- 1975-01-16 NL NL7500535A patent/NL7500535A/en unknown
- 1975-01-16 DE DE19752501468 patent/DE2501468A1/en active Pending
- 1975-01-23 AU AU77563/75A patent/AU7756375A/en not_active Expired
- 1975-01-23 GB GB299475A patent/GB1472342A/en not_active Expired
- 1975-01-23 ES ES434079A patent/ES434079A1/en not_active Expired
- 1975-01-23 FR FR7502129A patent/FR2258853B1/fr not_active Expired
- 1975-01-24 ZA ZA00750522A patent/ZA75522B/en unknown
- 1975-01-24 AT AT53175A patent/ATA53175A/en not_active IP Right Cessation
- 1975-01-24 IE IE137/75A patent/IE40368B1/en unknown
- 1975-01-24 BE BE152675A patent/BE824742A/en unknown
- 1975-01-24 IL IL46505A patent/IL46505A0/en unknown
- 1975-01-25 JP JP50010179A patent/JPS50106969A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE2501468A1 (en) | 1975-07-31 |
| ES434079A1 (en) | 1977-03-01 |
| IE40368L (en) | 1975-07-25 |
| FR2258853B1 (en) | 1978-06-30 |
| JPS50106969A (en) | 1975-08-22 |
| SE7500262L (en) | 1975-07-28 |
| BE824742A (en) | 1975-07-24 |
| FR2258853A1 (en) | 1975-08-22 |
| IL46505A0 (en) | 1975-04-25 |
| ATA53175A (en) | 1977-08-15 |
| GB1472342A (en) | 1977-05-04 |
| NL7500535A (en) | 1975-07-29 |
| DK3375A (en) | 1975-09-15 |
| AU7756375A (en) | 1976-07-29 |
| ZA75522B (en) | 1976-01-28 |
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