IE40368B1 - Derivatives of 2-(2-pyridylcarbonyl)-indole - Google Patents

Derivatives of 2-(2-pyridylcarbonyl)-indole

Info

Publication number
IE40368B1
IE40368B1 IE137/75A IE13775A IE40368B1 IE 40368 B1 IE40368 B1 IE 40368B1 IE 137/75 A IE137/75 A IE 137/75A IE 13775 A IE13775 A IE 13775A IE 40368 B1 IE40368 B1 IE 40368B1
Authority
IE
Ireland
Prior art keywords
indole
prepared
derivatives
substituted
picolyl
Prior art date
Application number
IE137/75A
Other versions
IE40368L (en
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of IE40368L publication Critical patent/IE40368L/en
Publication of IE40368B1 publication Critical patent/IE40368B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

1472342 Derivatives of 2-(2-picolyl)indole CIBA-GEIGY AG 23 Jan 1975 [25 Jan 1974] 2994/75 Heading C2C The invention comprises indoles-and their salts-which are substituted (a) in the 1-position by aliphatic hydrocarbyl (possibly aryl-substituted), and (b) in the 2-position by (possibly C 1-7 -alkyl substituted) picolinoyl or alphahydroxypicolyl, and optionally (c) in other ring positions. In examples, these compounds are prepared by (1) reducing the ketones to carbinols, or the reverse oxidation process, (2) converting substituent methoxy groups to OH, or (3) reacting together either (i) a 2-lithioindole with 2-formylpyridine or 2-picolinic acid, or (ii) a 2-lithiopyridine with the corresponding indole- 2-carboxylic acid (which reagents are themselves prepared by hydrolysis of the methyl or ethyl esters). The acids may react in the form of their Li salts. Starting materials otherwise prepared have the formula 2,5-MeNH(Cl)C 6 H 3 X, where X is CONHNH 2 , CONHNHO 2 SC 6 H 4 Me(-p) or CHO. Therapeutic compositions having fibrinolytic, thrombolytic and platelet aggregation inhibitive activity, comprise the above 2-(2-picolyl)indole derivatives, and may be administered orally or parenterally. [GB1472342A]
IE137/75A 1974-01-25 1975-01-24 Derivatives of 2-(2-pyridylcarbonyl)-indole IE40368B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH104774 1974-01-25

Publications (2)

Publication Number Publication Date
IE40368L IE40368L (en) 1975-07-25
IE40368B1 true IE40368B1 (en) 1979-05-09

Family

ID=4201215

Family Applications (1)

Application Number Title Priority Date Filing Date
IE137/75A IE40368B1 (en) 1974-01-25 1975-01-24 Derivatives of 2-(2-pyridylcarbonyl)-indole

Country Status (14)

Country Link
JP (1) JPS50106969A (en)
AT (1) ATA53175A (en)
AU (1) AU7756375A (en)
BE (1) BE824742A (en)
DE (1) DE2501468A1 (en)
DK (1) DK3375A (en)
ES (1) ES434079A1 (en)
FR (1) FR2258853B1 (en)
GB (1) GB1472342A (en)
IE (1) IE40368B1 (en)
IL (1) IL46505A0 (en)
NL (1) NL7500535A (en)
SE (1) SE7500262L (en)
ZA (1) ZA75522B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4999186A (en) * 1986-06-27 1991-03-12 The Procter & Gamble Company Novel sunscreen agents, sunscreen compositions and methods for preventing sunburn
CA2407677A1 (en) * 2000-04-28 2002-10-28 Baxter Healthcare Sa 2-acyl indol derivatives and their use as anti-tumour agents
DE10152306A1 (en) * 2001-10-26 2003-07-24 Asta Medica Ag 2-acylindole derivatives with new therapeutically valuable properties
JP2010540641A (en) * 2007-10-05 2010-12-24 アミラ ファーマシューティカルス，インコーポレーテッド 5-Lipoxygenase activating protein (FLAP) inhibitor
EP2845856A1 (en) 2009-06-29 2015-03-11 Incyte Corporation Pyrimidinones as PI3K inhibitors
US8680108B2 (en) 2009-12-18 2014-03-25 Incyte Corporation Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors
WO2011075643A1 (en) 2009-12-18 2011-06-23 Incyte Corporation Substituted heteroaryl fused derivatives as pi3k inhibitors
AR081823A1 (en) 2010-04-14 2012-10-24 Incyte Corp FUSIONATED DERIVATIVES AS PI3Kd INHIBITORS
US9062055B2 (en) 2010-06-21 2015-06-23 Incyte Corporation Fused pyrrole derivatives as PI3K inhibitors
US9096600B2 (en) 2010-12-20 2015-08-04 Incyte Corporation N-(1-(substituted-phenyl)ethyl)-9H-purin-6-amines as PI3K inhibitors
US9108984B2 (en) 2011-03-14 2015-08-18 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors
US9126948B2 (en) 2011-03-25 2015-09-08 Incyte Holdings Corporation Pyrimidine-4,6-diamine derivatives as PI3K inhibitors
BR112014004971B1 (en) 2011-09-02 2021-02-09 Incyte Holdings Corporation heterocyclyl amine compounds, their pharmaceutical composition and their uses
AR090548A1 (en) 2012-04-02 2014-11-19 Incyte Corp BICYCLIC AZAHETEROCICLOBENCILAMINS AS PI3K INHIBITORS
WO2015191677A1 (en) 2014-06-11 2015-12-17 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors
SI3831833T1 (en) 2015-02-27 2023-03-31 Incyte Holdings Corporation Processes for the preparation of a pi3k inhibitor
WO2016183063A1 (en) 2015-05-11 2016-11-17 Incyte Corporation Crystalline forms of a pi3k inhibitor
WO2016183060A1 (en) 2015-05-11 2016-11-17 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor

Also Published As

Publication number Publication date
GB1472342A (en) 1977-05-04
FR2258853B1 (en) 1978-06-30
JPS50106969A (en) 1975-08-22
ES434079A1 (en) 1977-03-01
NL7500535A (en) 1975-07-29
ATA53175A (en) 1977-08-15
SE7500262L (en) 1975-07-28
BE824742A (en) 1975-07-24
DK3375A (en) 1975-09-15
ZA75522B (en) 1976-01-28
AU7756375A (en) 1976-07-29
DE2501468A1 (en) 1975-07-31
IL46505A0 (en) 1975-04-25
FR2258853A1 (en) 1975-08-22
IE40368L (en) 1975-07-25

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