ES430104A1 - Cephalosporin compounds - Google Patents
Cephalosporin compoundsInfo
- Publication number
- ES430104A1 ES430104A1 ES430104A ES430104A ES430104A1 ES 430104 A1 ES430104 A1 ES 430104A1 ES 430104 A ES430104 A ES 430104A ES 430104 A ES430104 A ES 430104A ES 430104 A1 ES430104 A1 ES 430104A1
- Authority
- ES
- Spain
- Prior art keywords
- compound
- group
- formula
- nucleophile
- isomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/42—Singly bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/14—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Abstract
Procedure for the preparation of cephalosporin derivatives of the formula **(See formula)** (in R it is a hydrogen atom or an organic group, Ra is an etherifying monovalent organic group attached to the oxygen atom through a carbon atom, B is> that S or> S (see graph), and P is a group -CH2Y where Y is the remainder of a nucleophile or a derivative of the remainder of a nucleophile, and non-toxic derivatives thereof, comprising reacting a compound of the formula **(See formula)** (in which Acil is the group (see formula) where R and Ra have the previously defined meanings or a precursor thereto, B is as defined above, R1 is a hydrogen atom or a carboxyl blocking group, Y'is a substitutable moiety of a nucleophile and the line of dashes bridging positions 2, 3 and 4 indicates that the compound can be a cef-2-em or cef-3-em compound, with a nucleophile, after which, if necessary or desired in each case, carry out any of the following reactions: (i) conversion of a precursor to the desired group (see formula) in the cited group, (ii) conversion of a Δ 2 isomer to the desired Δ 3 isomer, (iii) removal of any carboxyl blocking groups, (iv) reduction of a compound in which B is> that S (see graph) to form the corresponding compound in which B is> that S, (v) reduction of a compound in which Y is azide to form a 3-aminomethyl compound, (vi) reaction of a compound in which Y is azide with a dipolarphile to form a compound having a polyazole ring attached to the 3-methylene group, (vii) deacylation of a compound in which Y is an acyloxy group to form a 3-hydroxymethyl compound, and (viii) acylation of a compound in which Y is hydroxy to form a 3-acyloxymethyl compound; and, finally, recovering the desired compound of formula I or a non-toxic derivative thereof in the form of the isomer without or in the form of a mixture of isomers containing at least 75% of the isomer without. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1508271A GB1399086A (en) | 1971-05-14 | 1971-05-14 | Cephalosporin compounds |
GB4588471 | 1971-10-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES430104A1 true ES430104A1 (en) | 1976-10-01 |
Family
ID=26251025
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES402651A Expired ES402651A1 (en) | 1971-05-14 | 1972-05-12 | Cephalosporin compounds |
ES430104A Expired ES430104A1 (en) | 1971-05-14 | 1974-09-16 | Cephalosporin compounds |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES402651A Expired ES402651A1 (en) | 1971-05-14 | 1972-05-12 | Cephalosporin compounds |
Country Status (22)
Country | Link |
---|---|
JP (3) | JPS531280B1 (en) |
AT (1) | AT336786B (en) |
BE (1) | BE783449A (en) |
CA (1) | CA1027554A (en) |
CH (1) | CH591497A5 (en) |
CS (2) | CS245753B2 (en) |
CY (1) | CY971A (en) |
DE (2) | DE2265234C2 (en) |
DK (1) | DK155187C (en) |
ES (2) | ES402651A1 (en) |
FR (2) | FR2137899B1 (en) |
GB (1) | GB1399086A (en) |
HK (1) | HK66078A (en) |
IE (1) | IE38172B1 (en) |
IL (1) | IL39429A (en) |
KE (1) | KE2895A (en) |
MY (1) | MY7800466A (en) |
NL (1) | NL166688C (en) |
NO (1) | NO154797C (en) |
PH (1) | PH11205A (en) |
SE (1) | SE457795B (en) |
YU (2) | YU41807B (en) |
Families Citing this family (124)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4064346A (en) * | 1971-05-14 | 1977-12-20 | Glaxo Laboratories Limited | 3-Acetoxymethyl-7β-(2-carboxy-methoxyimino-2-arylacetamido)ceph-3-em-4-carboxylic acids and salts thereof |
GB1445979A (en) * | 1972-10-25 | 1976-08-11 | Glaxo Lab Ltd | Cephalosporin derivatives |
US4079178A (en) * | 1971-05-14 | 1978-03-14 | Glaxo Laboratories Limited | Cephalosporins having (α-etherified oximino) acylamido groups at the 7-position |
US4033950A (en) * | 1971-05-14 | 1977-07-05 | Glaxo Laboratories Limited | 3-Hydroxymethyl-7β-(2-alkoxy-or benzyloxyimino-2-arylacetamido)ceph-3-em-4-carboxylic acids and salts thereof |
GB1399086A (en) * | 1971-05-14 | 1975-06-25 | Glaxo Lab Ltd | Cephalosporin compounds |
US4138555A (en) | 1971-05-14 | 1979-02-06 | Glaxo Laboratories, Limited | (6R,7R)-7-[2-aryl-2-(etherified oximino)acetamido]-3-carbamoyloxymethylceph-3-em-4-carboxylic acid 1-oxides |
AR208283A1 (en) * | 1973-03-15 | 1976-12-20 | Fujisawa Pharmaceutical Co | A PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF 2-ALKYL-2-O 3-FEFEM-4-CARBOXYL ACID |
JPS5844675B2 (en) * | 1973-12-21 | 1983-10-04 | グラクソ ラボラトリ−ス リミテツド | The best way to go about it |
US4144393A (en) | 1973-12-21 | 1979-03-13 | Glaxo Laboratories Limited | 3-Acetoxymethyl cephalosporins having at position-7 a carboxy substituted α-etherified hydroxyiminoarylacetamido group |
US4144392A (en) | 1973-12-21 | 1979-03-13 | Glaxo Laboratories Limited | Cephalosporins having at position-7 a carboxy substituted α-etherified hydroxyimino-arylacetamido group and at position-3 the residue of a sulphur nucleophile |
GB1512957A (en) * | 1974-08-23 | 1978-06-01 | Glaxo Lab Ltd | Gephalosporin antibiotics |
DK154939C (en) * | 1974-12-19 | 1989-06-12 | Takeda Chemical Industries Ltd | METHOD OF ANALOGUE FOR THE PREPARATION OF THIAZOLYLACETAMIDO-CEPHEM COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE SALTS OR ESTERS THEREOF |
US4200746A (en) | 1974-12-20 | 1980-04-29 | Glaxo Laboratories, Ltd. | Cephalosporins |
GB1522140A (en) * | 1974-12-20 | 1978-08-23 | Glaxo Lab Ltd | Syn-7-(2-hydroxyiminoacetamido)-3-pyridiniummethyl cephalosporins methods for their preparation and compositions containing them |
FI66005C (en) * | 1975-02-04 | 1984-08-10 | Fujisawa Pharmaceutical Co | FRUIT PROTECTION FOR ANTIBACTERIAL VERIFICATION OF 7-ALPHA ALPHA-DISUBSTITUTE-ACETAMIDO) -3-SUBSTITUTER-3-CEFE M - CARBOXYL SYRINE SYN-ISOMER |
GB1555471A (en) * | 1975-06-19 | 1979-11-14 | Glaxo Lab Ltd | 7 carbamoylalkoxyimino acetamido 3 em 4 carboxylic acidsand derivatives thereof |
DE2760123C2 (en) | 1976-01-23 | 1986-04-30 | Roussel-Uclaf, Paris | 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporanic acids, their preparation and pharmaceutical compositions containing them |
SE440655B (en) * | 1976-01-23 | 1985-08-12 | Roussel Uclaf | SET TO MAKE NEW OXIME DERIVATIVES OF 7-AMINO-THIAZOLYL-ACETAMIDO-CEPHALOSPORANIC ACID |
IE44888B1 (en) * | 1976-03-09 | 1982-05-05 | Fujisawa Pharmaceutical Co | 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation theroef |
GB1575803A (en) | 1976-03-09 | 1980-10-01 | Fujisawa Pharmaceutical Co | 3,7 disubstituted 3 cephem 4 carboxylic acid compounds andprocesses for the preparation thereof |
US4165430A (en) | 1976-03-19 | 1979-08-21 | Glaxo Laboratories Limited | Cephalosporins having a 7-carboxy substituted α-etherified oximinoarylacetamido) group |
FR2345153A1 (en) * | 1976-03-25 | 1977-10-21 | Roussel Uclaf | NEW ALCOYLOXIMES DERIVED FROM 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
US4166115A (en) * | 1976-04-12 | 1979-08-28 | Fujisawa Pharmaceutical Co., Ltd. | Syn 7-oxoimino substituted derivatives of cephalosporanic acid |
DK162391C (en) * | 1976-04-12 | 1992-03-09 | Fujisawa Pharmaceutical Co | ANALOGY PROCEDURE FOR PREPARING SYN-ISOMERS OF 3,7-DISUBSTITUTED 3-CEPHEM-4-CARBOXYLIC ACID COMPOUNDS |
DE2760484C2 (en) * | 1976-04-14 | 1992-12-03 | Takeda Chemical Industries, Ltd., Osaka, Jp | |
US4066762A (en) * | 1976-07-12 | 1978-01-03 | Smithkline Corporation | Derivatives of 7-(2-substituted-2-hydroxyiminoacetamido)-3-(1-substituted tetrazol-5-ylthiomethyl-3-cephem-4-carboxylic acid |
US4278670A (en) * | 1976-07-12 | 1981-07-14 | Smithkline Corporation | 7-Alpha-oxyiminoacylcephalosporins |
FR2361895A1 (en) * | 1976-08-20 | 1978-03-17 | Roussel Uclaf | NEW OXIMES DERIVED FROM 3-CARBAMOYLOXYMETHYL 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
GB1592149A (en) * | 1976-10-08 | 1981-07-01 | Fujisawa Pharmaceutical Co | 3 7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for preparation thereof |
JPS53103493A (en) * | 1977-02-18 | 1978-09-08 | Takeda Chem Ind Ltd | Cephalosporin derivatives and process for their preparation |
FR2381053A1 (en) * | 1977-02-18 | 1978-09-15 | Roussel Uclaf | NEW OXIMES DERIVED FROM 3-THIADIAZOLYL THIOMETHYL 7-AMINOTHIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
PH17188A (en) | 1977-03-14 | 1984-06-14 | Fujisawa Pharmaceutical Co | New cephem and cepham compounds and their pharmaceutical compositions and method of use |
FR2384779A1 (en) * | 1977-03-25 | 1978-10-20 | Roussel Uclaf | NEW OXIMES DERIVED FROM 3-CHLORO OR 3-METHOXY 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
SE439312B (en) | 1977-03-25 | 1985-06-10 | Roussel Uclaf | SET TO MAKE NEW OXIME DERIVATIVES OF 3-ACETOXIMETHYL-7-AMINOTIAZOLYLACETAMIDO CEPHALOSPORANIC ACID |
DE2714880A1 (en) * | 1977-04-02 | 1978-10-26 | Hoechst Ag | CEPHEMDER DERIVATIVES AND PROCESS FOR THEIR PRODUCTION |
DE2716677C2 (en) * | 1977-04-15 | 1985-10-10 | Hoechst Ag, 6230 Frankfurt | Cephem derivatives and processes for their preparation |
GB1599232A (en) * | 1977-06-03 | 1981-09-30 | Hoffmann La Roche | 7-(2-oximinoacetamido)-cephalosporin derivatives |
IT1192287B (en) * | 1977-11-14 | 1988-03-31 | Fujisawa Pharmaceutical Co | PHARMACEUTICAL ACTION DERIVATIVES OF CEPHALOSPORANIC ACID AND RELATED PREPARATION PROCEDURE |
SE445350B (en) * | 1978-04-14 | 1986-06-16 | Roussel Uclaf | OXIMO DERIVATIVES OF 3-AZIDOMETHYL-7-AMINO-THIAZOLYL-ACETAMIDO-CEPHALOSPORANIC ACID AND ITS USE AS ANTIBIOTICS |
FR2438051A2 (en) * | 1978-10-05 | 1980-04-30 | Roussel Uclaf | 3-Azido:methyl-3-cephem-4-carboxylic acid derivs. - useful as broad-spectrum antibacterial agents and disinfectants (BE 15.10.79) |
AR229883A1 (en) | 1978-05-26 | 1983-12-30 | Glaxo Group Ltd | PROCEDURE FOR THE PREPARATION OF ANTIBIOTIC (6R, 7R) -7 - ((Z) -2- (2-AMINOTIAZOL-4-IL) -2- (2-CARBOXIPROP-2-OXIIMINO) -ACETAMIDO) -3- (1 -PIRIDINOMETIL) -CEF-3-EM-4-CARBOXYLATE |
DE2822860A1 (en) * | 1978-05-26 | 1979-11-29 | Hoechst Ag | CEPHEM DERIVATIVES AND METHOD FOR THEIR PRODUCTION |
DE2822861A1 (en) * | 1978-05-26 | 1979-11-29 | Hoechst Ag | CEPHEMDER DERIVATIVES AND PROCESS FOR THEIR PRODUCTION |
US4268509A (en) * | 1978-07-10 | 1981-05-19 | Fujisawa Pharmaceutical Co., Ltd. | New cephem compounds and processes for preparation thereof |
US4284631A (en) * | 1978-07-31 | 1981-08-18 | Fujisawa Pharmaceutical Co., Ltd. | 7-Substituted cephem compounds and pharmaceutical antibacterial compositions containing them |
DE2946038A1 (en) * | 1978-11-15 | 1980-05-29 | Glaxo Group Ltd | CEPHALOSPORINANTIBIOTICS |
DE2914327A1 (en) * | 1979-04-09 | 1980-10-30 | Hoechst Ag | CEPHEM DERIVATIVES AND METHOD FOR THEIR PRODUCTION |
DE3069560D1 (en) * | 1979-09-03 | 1984-12-06 | Fujisawa Pharmaceutical Co | Cephem compounds, processes for their preparation and pharmaceutical compositions containing them |
US4341777A (en) * | 1979-09-10 | 1982-07-27 | Glaxo Group Limited | Cephalosporin antibiotic |
EP0027599B1 (en) * | 1979-10-12 | 1984-10-03 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds, processes for their preparation and pharmaceutical compositions containing them |
FR2476087A1 (en) * | 1980-02-18 | 1981-08-21 | Roussel Uclaf | NOVEL OXIMES DERIVED FROM 3-ALKYLOXY OR 3-ALKYL-THIOMETHYL 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, PROCESS FOR PREPARING THEM AND THEIR APPLICATION AS MEDICAMENTS |
EP0104671B1 (en) * | 1980-02-18 | 1990-05-23 | Roussel-Uclaf | Oxime derivatives of 3-alkyloxy or 3-alkylthiomethyl-7-amino-thiazolylacetamido-cephalosporanic acid, their preparation, their use as medicines and compositions containing them |
EP0037797A3 (en) * | 1980-03-11 | 1981-12-16 | Ciba-Geigy Ag | Cephalosporin derivatives, process for their preparation, pharmaceutical compositions containing them and their application |
GR75644B (en) * | 1980-06-18 | 1984-08-02 | Fujisawa Pharmaceutical Co | |
ZA813787B (en) * | 1980-06-18 | 1982-07-28 | Fujisawa Pharmaceutical Co | New cephem compounds and processes for preparation thereof |
IL63207A (en) * | 1980-07-24 | 1985-09-29 | Lonza Ag | Process for the preparation of 2-(2-aminothiazole-4-yl)-2-(syn)-methoxyiminoacetic acid esters |
US4443444A (en) * | 1980-08-11 | 1984-04-17 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
EP0046964B1 (en) * | 1980-08-29 | 1986-08-20 | Fujisawa Pharmaceutical Co., Ltd. | New cephem compounds and processes for preparation thereof |
US4416879A (en) * | 1980-09-08 | 1983-11-22 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
NZ198350A (en) * | 1980-09-25 | 1985-02-28 | Toyama Chemical Co Ltd | Cephalosporins and intermediates;pharmaceutical compositions |
US4458072A (en) * | 1980-10-10 | 1984-07-03 | Hoffmann-La Roche Inc. | Acyl derivatives |
FR2494274A2 (en) * | 1980-11-20 | 1982-05-21 | Rhone Poulenc Ind | NEW THIOVINYL-3 CEPHALOSPORINS, THEIR PREPARATION AND THE MEDICINES THAT CONTAIN THEM |
FR2494280A1 (en) * | 1980-11-20 | 1982-05-21 | Rhone Poulenc Ind | NEW DERIVATIVES OF CEPHALOSPORINE AND THEIR PREPARATION |
FR2494275A2 (en) * | 1980-11-20 | 1982-05-21 | Rhone Poulenc Ind | NEW DERIVATIVES OF VINYL-3 CEPHALOSPORINS AND THEIR PREPARATION |
FR2494279A1 (en) * | 1980-11-20 | 1982-05-21 | Rhone Poulenc Ind | NEW OXACEPHALOSPORINS, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM |
FR2494276A2 (en) * | 1980-11-20 | 1982-05-21 | Rhone Poulenc Ind | NEW VINYL-3 CEPHALOSPORINS, AND THEIR PREPARATION |
GR76342B (en) * | 1981-02-02 | 1984-08-06 | Fujisawa Pharmaceutical Co | |
FR2499995A1 (en) * | 1981-02-13 | 1982-08-20 | Roussel Uclaf | 7-2-2-Amino-4-thiazolyl 2-hydroxy:imino-acetamido 3-cephem derivs. - 3-substd. by alkoxy- or alkyl-thio-methyl are antibiotics active against gram positive and gram negative bacteria |
JPS6011917B2 (en) * | 1981-04-09 | 1985-03-28 | 山之内製薬株式会社 | Novel cephalosporin compounds |
FR2505338A1 (en) * | 1981-05-11 | 1982-11-12 | Rhone Poulenc Sante | 3-Substd. thio-vinyl 1-oxa-ceph-3-em-4-carboxylic acid antibacterials - esp. having 7-2-2-amino-4-thiazolyl-2-methoxy:imino-acetamido Gp., 3-thio substits. include thiadiazolyl and triazinyl Gps. |
FR2505339A1 (en) * | 1981-05-11 | 1982-11-12 | Rhone Poulenc Sante | 3-Substd. thio-vinyl 1-oxa-ceph-3-em-4-carboxylic acid antibacterials - esp. having 7-2-2-amino-4-thiazolyl-2-methoxy:imino-acetamido Gp., 3-thio substits. include thiadiazolyl and triazinyl Gps. |
EP0070803A3 (en) * | 1981-07-16 | 1984-05-02 | Ciba-Geigy Ag | Antibiotically active aminotriazolylcephalosporin derivatives and their preparation |
SU1169542A3 (en) * | 1981-09-08 | 1985-07-23 | Эли Лилли Энд Компани (Фирма) | Method of obtaining thienopyridine-of furopyridine-substituted derivatives of cephalosporin |
JPS5859992A (en) * | 1981-09-14 | 1983-04-09 | Fujisawa Pharmaceut Co Ltd | Novel cephen compound, its preparation and preventing agent and remedy for microbism |
US4521413A (en) * | 1981-09-14 | 1985-06-04 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
MA19602A1 (en) * | 1981-09-30 | 1983-04-01 | Ciba Geigy Ag | AMINO-OXAZOLYL COMPOUNDS, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS, AND THEIR APPLICATION |
US4401668A (en) * | 1981-10-02 | 1983-08-30 | Eli Lilly And Company | Pyrazinium substituted cephalosporins |
US4394503A (en) | 1981-12-07 | 1983-07-19 | Bristol-Myers Company | Cephalosporin derivatives |
US4474954A (en) * | 1981-12-07 | 1984-10-02 | Bristol-Myers Company | Intermediates for cephalosporin derivatives |
US4406899A (en) | 1982-03-04 | 1983-09-27 | Bristol-Myers Company | Cephalosporins |
US4457929A (en) * | 1982-03-29 | 1984-07-03 | Bristol-Myers Company | 3-Quaternary ammonium methyl)-substituted cephalosporin derivatives |
PH19163A (en) * | 1982-04-06 | 1986-01-16 | Daiichi Seiyaku Co | Cephalosporin derivatives |
JPS5910593A (en) | 1982-06-28 | 1984-01-20 | Bristol Mayers Kenkyusho Kk | Cephalosporin derivative |
US4500526A (en) * | 1982-06-28 | 1985-02-19 | Bristol-Myers Company | Cephalosporin derivatives |
GB2125033B (en) * | 1982-07-23 | 1985-08-29 | Servipharm Ltd | Cephalosporins |
IL69246A (en) * | 1982-08-07 | 1986-07-31 | Tanabe Seiyaku Co | 7-((2-aminothiazolyl-2-pyrrolidonyl or(piperidonyl)-oxyimino)acetamido)cephem carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them |
US4546101A (en) * | 1982-09-10 | 1985-10-08 | Fujisawa Pharmaceutical Co., Ltd. | New cephem compounds useful for treating infectious diseases in human being and animals and processes for preparation thereof |
FR2533216A1 (en) * | 1982-09-22 | 1984-03-23 | Toyama Chemical Co Ltd | New cephalosporins and their salts. |
JPS5973043A (en) * | 1982-10-19 | 1984-04-25 | House Food Ind Co Ltd | Method for modifying quality of hardly soluble gelling agent |
US4486586A (en) * | 1983-02-10 | 1984-12-04 | Bristol-Myers Company | Cephalosporin derivatives |
US4525473A (en) * | 1983-03-30 | 1985-06-25 | Bristol-Myers Company | Cephalosporins |
US4492693A (en) * | 1983-04-12 | 1985-01-08 | Eli Lilly And Company | Benzothienylglycyl cephalosporin derivatives |
GB2137993A (en) * | 1983-04-12 | 1984-10-17 | Lilly Co Eli | Improvements in or relating to naphthylglycyl cephalosporin derivatives |
US4482553A (en) * | 1983-04-12 | 1984-11-13 | Eli Lilly And Company | Benzothienylglycyl cephalosporin derivatives |
US4492694A (en) * | 1983-04-12 | 1985-01-08 | Eli Lilly And Company | Indolylglycyl cephalosporin derivatives |
DE3330605A1 (en) * | 1983-08-25 | 1985-03-14 | Hoechst Ag, 6230 Frankfurt | CEPHALOSPORINE DERIVATIVES AND METHOD FOR THEIR PRODUCTION |
JPS60190783A (en) * | 1983-12-21 | 1985-09-28 | Sumitomo Seiyaku Kk | Cephem compound |
JPS60132983A (en) * | 1983-12-21 | 1985-07-16 | Tanabe Seiyaku Co Ltd | Thiazoleacetic acid derivative and its production |
JPS60142987A (en) * | 1983-12-29 | 1985-07-29 | Mochida Pharmaceut Co Ltd | Cephalosporin derivative |
DE3485860T2 (en) * | 1983-12-29 | 1993-01-14 | Mochida Pharm Co Ltd | CEPHALOSPORINE COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS. |
GB8411954D0 (en) * | 1984-05-10 | 1984-06-13 | Glaxo Group Ltd | Cephalosporin antibiotics |
FI851934L (en) * | 1984-05-30 | 1985-12-01 | Ici Plc | KEFALOSPORINDERIVAT. |
IE58487B1 (en) * | 1984-09-07 | 1993-09-22 | Kaisha Maiji Seika | New cephalosporin compounds and the production thereof |
EP0182633A3 (en) * | 1984-11-20 | 1987-09-02 | Ici Pharma | Cephalosporin derivatives |
JPS61145186A (en) * | 1984-12-20 | 1986-07-02 | Meiji Seika Kaisha Ltd | Novel cephem compound and preparation thereof |
EP0186187B1 (en) * | 1984-12-27 | 1992-02-26 | Banyu Pharmaceutical Co., Ltd. | Cephalosporin derivatives |
US4840945A (en) * | 1985-04-01 | 1989-06-20 | Mochida Pharmaceutical Co., Ltd. | Cephalosporin derivatives |
US4874856A (en) * | 1985-06-24 | 1989-10-17 | Bristol-Myers Company | 3-(substituted)propenyl-7-(aminothiazolylacetamido) ceph-3-em-4-carboxylic acids and esters thereof |
US4708955A (en) * | 1985-06-24 | 1987-11-24 | Bristol-Myers Company | 3-(substituted)propenyl-7-aminothiazol-ylcephalosporanic acids and esters thereof |
US4814328A (en) * | 1986-03-19 | 1989-03-21 | Banyu Pharmaceutical Co., Ltd. | Cephalosporin derivatives, and antibacterial agents |
DE3623921A1 (en) * | 1986-07-16 | 1988-01-21 | Basf Ag | OXIMETHER AND FUNGICIDES CONTAINING THEM |
ZA877987B (en) * | 1986-11-12 | 1988-08-31 | Ici Pharma | Antibiotic compounds |
US4880798A (en) * | 1986-11-25 | 1989-11-14 | Mochida Pharmaceutical Co., Ltd. | Cephalosporin derivatives |
JPS63132893A (en) * | 1986-11-25 | 1988-06-04 | Mochida Pharmaceut Co Ltd | Novel cephalosporin derivative, production thereof and antibacterial agent containing said derivative as active ingredient |
US5262410A (en) * | 1986-12-23 | 1993-11-16 | Ici Pharma | 3-heterocyclic thiomethyl cephalosporins |
EP0272827A3 (en) * | 1986-12-23 | 1990-02-07 | ZENECA Pharma S.A. | 3-heterocyclicthiomethyl cephalosphorins |
US5189157A (en) * | 1987-06-16 | 1993-02-23 | Hoffmann La Roche Inc. | Antibacterial cephalosporin compounds |
ATE131824T1 (en) * | 1987-07-23 | 1996-01-15 | Zeneca Pharma Sa | CEPHALOSPORIN COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME |
ATE130299T1 (en) * | 1987-07-23 | 1995-12-15 | Zeneca Pharma Sa | CEPHALOSPORIN COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME. |
KR900006811B1 (en) * | 1988-05-11 | 1990-09-21 | 주식회사 럭 키 | Cephalosphorin derivatives and its process |
US5202315A (en) * | 1989-05-11 | 1993-04-13 | Lucky, Ltd. | Cephalosporin compounds |
GB8927871D0 (en) * | 1989-12-08 | 1990-02-14 | Beecham Group Plc | Novel compounds |
IN189046B (en) | 1998-03-30 | 2002-12-14 | Ranbaxy Lab Ltd | |
WO2000053609A1 (en) * | 1999-03-09 | 2000-09-14 | Ranbaxy Laboratories Limited | Process for the preparation of cefuroxime |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE311519B (en) * | 1962-12-14 | 1969-06-16 | Astra Ab | |
GB1208014A (en) * | 1967-03-23 | 1970-10-07 | Glaxo Lab Ltd | Cephalosporins |
GB1208015A (en) * | 1967-03-23 | 1970-10-07 | Glaxo Lab Ltd | Cephalosporins |
GB1241657A (en) * | 1967-08-21 | 1971-08-04 | Glaxo Lab Ltd | Improvements in or relating to cephalosporin compounds |
GB1279402A (en) * | 1968-06-14 | 1972-06-28 | Glaxo Lab Ltd | Improvements in or relating to cephalosporin derivatives |
US3641021A (en) * | 1969-04-18 | 1972-02-08 | Lilly Co Eli | 3 7-(ring-substituted) cephalosporin compounds |
ZA72568B (en) * | 1971-01-29 | 1972-10-25 | Glaxo Lab Ltd | Improvements in or relating to antibiotics |
GB1399086A (en) * | 1971-05-14 | 1975-06-25 | Glaxo Lab Ltd | Cephalosporin compounds |
-
1971
- 1971-05-14 GB GB1508271A patent/GB1399086A/en not_active Expired
-
1972
- 1972-05-12 NL NLAANVRAGE7206403,A patent/NL166688C/en not_active IP Right Cessation
- 1972-05-12 CS CS723209A patent/CS245753B2/en unknown
- 1972-05-12 SE SE7206296A patent/SE457795B/en unknown
- 1972-05-12 YU YU1267/72A patent/YU41807B/en unknown
- 1972-05-12 IL IL39429A patent/IL39429A/en unknown
- 1972-05-12 BE BE783449A patent/BE783449A/en not_active IP Right Cessation
- 1972-05-12 DE DE2265234A patent/DE2265234C2/en not_active Expired
- 1972-05-12 IE IE644/72A patent/IE38172B1/en unknown
- 1972-05-12 JP JP4714872A patent/JPS531280B1/ja active Pending
- 1972-05-12 NO NO721705A patent/NO154797C/en unknown
- 1972-05-12 DK DK237372A patent/DK155187C/en active
- 1972-05-12 ES ES402651A patent/ES402651A1/en not_active Expired
- 1972-05-12 CA CA141,965A patent/CA1027554A/en not_active Expired
- 1972-05-12 CH CH705972A patent/CH591497A5/xx not_active IP Right Cessation
- 1972-05-12 CS CS72839A patent/CS245754B2/en unknown
- 1972-05-12 CY CY971A patent/CY971A/en unknown
- 1972-05-12 DE DE2223375A patent/DE2223375C2/en not_active Expired
- 1972-05-15 FR FR7217283A patent/FR2137899B1/fr not_active Expired
- 1972-05-15 FR FR7217284A patent/FR2137900B1/fr not_active Expired
- 1972-05-15 AT AT420872A patent/AT336786B/en not_active IP Right Cessation
-
1974
- 1974-08-23 PH PH16206A patent/PH11205A/en unknown
- 1974-09-16 ES ES430104A patent/ES430104A1/en not_active Expired
-
1977
- 1977-06-22 JP JP7426977A patent/JPS5328141A/en active Granted
-
1978
- 1978-10-19 KE KE2895A patent/KE2895A/en unknown
- 1978-11-16 HK HK660/78A patent/HK66078A/en unknown
- 1978-12-30 MY MY466/78A patent/MY7800466A/en unknown
-
1979
- 1979-02-24 JP JP2128779A patent/JPS54135792A/en active Pending
- 1979-12-28 YU YU03213/79A patent/YU321379A/en unknown
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