FR2137899A1 - - Google Patents

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Publication number
FR2137899A1
FR2137899A1 FR7217283A FR7217283A FR2137899A1 FR 2137899 A1 FR2137899 A1 FR 2137899A1 FR 7217283 A FR7217283 A FR 7217283A FR 7217283 A FR7217283 A FR 7217283A FR 2137899 A1 FR2137899 A1 FR 2137899A1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7217283A
Other languages
French (fr)
Other versions
FR2137899B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26251025&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2137899(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Publication of FR2137899A1 publication Critical patent/FR2137899A1/fr
Application granted granted Critical
Publication of FR2137899B1 publication Critical patent/FR2137899B1/fr
Expired legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40Radicals substituted by oxygen atoms
    • C07D307/42Singly bound oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/14Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by halogen atoms or by nitro or nitroso groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55Acids; Esters
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D499/00Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
FR7217283A 1971-05-14 1972-05-15 Expired FR2137899B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1508271A GB1399086A (en) 1971-05-14 1971-05-14 Cephalosporin compounds
GB4588471 1971-10-01

Publications (2)

Publication Number Publication Date
FR2137899A1 true FR2137899A1 (en) 1972-12-29
FR2137899B1 FR2137899B1 (en) 1976-08-20

Family

ID=26251025

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7217284A Expired FR2137900B1 (en) 1971-05-14 1972-05-15
FR7217283A Expired FR2137899B1 (en) 1971-05-14 1972-05-15

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR7217284A Expired FR2137900B1 (en) 1971-05-14 1972-05-15

Country Status (22)

Country Link
JP (3) JPS531280B1 (en)
AT (1) AT336786B (en)
BE (1) BE783449A (en)
CA (1) CA1027554A (en)
CH (1) CH591497A5 (en)
CS (2) CS245754B2 (en)
CY (1) CY971A (en)
DE (2) DE2265234C2 (en)
DK (1) DK155187C (en)
ES (2) ES402651A1 (en)
FR (2) FR2137900B1 (en)
GB (1) GB1399086A (en)
HK (1) HK66078A (en)
IE (1) IE38172B1 (en)
IL (1) IL39429A (en)
KE (1) KE2895A (en)
MY (1) MY7800466A (en)
NL (1) NL166688C (en)
NO (1) NO154797C (en)
PH (1) PH11205A (en)
SE (1) SE457795B (en)
YU (2) YU41807B (en)

Cited By (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2204403A2 (en) * 1972-10-25 1974-05-24 Glaxo Lab Ltd
FR2282275A1 (en) * 1974-08-23 1976-03-19 Glaxo Lab Ltd IMPROVEMENTS RELATED TO ANTIBIOTICS
FR2348219A1 (en) * 1976-04-12 1977-11-10 Fujisawa Pharmaceutical Co PROCESS FOR PREPARING SYN ISOMERS OF 3,7-CEPHEM-4-CARBOXYLIC 3,7-DISUBSTITUTED ACID COMPOUNDS AND NEW PRODUCTS THUS OBTAINED, WITH ANTIBACTERIAL ACTIVITY
FR2348218A1 (en) * 1976-04-14 1977-11-10 Takeda Chemical Industries Ltd NEW CEPHALOSPORIN DERIVATIVES WITH A NEW 7-ACYL GROUP AND THEIR MANUFACTURING PROCESS
FR2361895A1 (en) * 1976-08-20 1978-03-17 Roussel Uclaf NEW OXIMES DERIVED FROM 3-CARBAMOYLOXYMETHYL 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS
FR2381053A1 (en) * 1977-02-18 1978-09-15 Roussel Uclaf NEW OXIMES DERIVED FROM 3-THIADIAZOLYL THIOMETHYL 7-AMINOTHIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS
FR2381052A1 (en) * 1977-02-18 1978-09-15 Takeda Chemical Industries Ltd CEPHALOSPORIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR USE
FR2384779A1 (en) * 1977-03-25 1978-10-20 Roussel Uclaf NEW OXIMES DERIVED FROM 3-CHLORO OR 3-METHOXY 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS
FR2385722A1 (en) * 1977-04-02 1978-10-27 Hoechst Ag NEW CEPHALOSPORIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
FR2387234A1 (en) * 1977-04-15 1978-11-10 Hoechst Ag CEPHALOSPORIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATIONS
EP0000005A1 (en) * 1977-06-03 1978-12-20 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft New cephalosporin derivatives, their preparations and their pharmaceutical compositions
FR2411839A1 (en) * 1977-11-14 1979-07-13 Fujisawa Pharmaceutical Co CEPHALOSPORANIC ACID DERIVATIVES, METHODS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM
FR2438051A2 (en) * 1978-10-05 1980-04-30 Roussel Uclaf 3-Azido:methyl-3-cephem-4-carboxylic acid derivs. - useful as broad-spectrum antibacterial agents and disinfectants (BE 15.10.79)
EP0025199A2 (en) * 1979-09-03 1981-03-18 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds, processes for their preparation and pharmaceutical compositions containing them
EP0027599A2 (en) * 1979-10-12 1981-04-29 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds, processes for their preparation and pharmaceutical compositions containing them
EP0034536A2 (en) * 1980-02-18 1981-08-26 Roussel-Uclaf Oxime derivatives of 3-alkyloxy- or 3-alkylthiomethyl 7-amino-thiazolylacetamido cephalosporanic acid, their preparation, their use as medicaments and compositions containing them
EP0037797A2 (en) * 1980-03-11 1981-10-14 Ciba-Geigy Ag Cephalosporin derivatives, process for their preparation, pharmaceutical compositions containing them and their application
EP0042154A1 (en) * 1980-06-18 1981-12-23 Fujisawa Pharmaceutical Co., Ltd. New cephem compounds and processes for preparation thereof
EP0045937A2 (en) * 1980-08-11 1982-02-17 Fujisawa Pharmaceutical Co., Ltd. New cephem compounds and processes for preparation thereof
EP0046964A2 (en) * 1980-08-29 1982-03-10 Fujisawa Pharmaceutical Co., Ltd. New cephem compounds and processes for preparation thereof
EP0047491A2 (en) * 1980-09-08 1982-03-17 Fujisawa Pharmaceutical Co., Ltd. New cephem compounds and processes for preparation thereof
EP0049855A2 (en) * 1980-10-10 1982-04-21 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Cephalosporin derivatives, process for their preparation, pharmaceutical compositions containing them and intermediates for their preparation
FR2494279A1 (en) * 1980-11-20 1982-05-21 Rhone Poulenc Ind NEW OXACEPHALOSPORINS, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM
EP0053074A1 (en) * 1980-11-20 1982-06-02 Rhone-Poulenc Sante Cephalosporin derivatives and their preparation
EP0053538A2 (en) * 1980-11-20 1982-06-09 Rhone-Poulenc Sante Vinyl-3 cephalosporin derivatives and their preparation
EP0053537A1 (en) * 1980-11-20 1982-06-09 Rhone-Poulenc Sante Vinyl-3 cephalosporin derivatives and their preparation
EP0053961A1 (en) * 1980-11-20 1982-06-16 Rhone-Poulenc Sante Thiovinyl-3-cephalosporin derivatives, their preparation and pharmaceutical compositions containing them
EP0057422A2 (en) * 1981-02-02 1982-08-11 Fujisawa Pharmaceutical Co., Ltd. New cephem compounds, processes for preparation thereof and pharmaceutical composition containing them
FR2499995A1 (en) * 1981-02-13 1982-08-20 Roussel Uclaf 7-2-2-Amino-4-thiazolyl 2-hydroxy:imino-acetamido 3-cephem derivs. - 3-substd. by alkoxy- or alkyl-thio-methyl are antibiotics active against gram positive and gram negative bacteria
FR2503712A1 (en) * 1981-04-09 1982-10-15 Yamanouchi Pharma Co Ltd CEPHALOSPORINE COMPOUNDS AND PROCESS FOR THEIR PREPARATION
FR2505338A1 (en) * 1981-05-11 1982-11-12 Rhone Poulenc Sante 3-Substd. thio-vinyl 1-oxa-ceph-3-em-4-carboxylic acid antibacterials - esp. having 7-2-2-amino-4-thiazolyl-2-methoxy:imino-acetamido Gp., 3-thio substits. include thiadiazolyl and triazinyl Gps.
FR2505339A1 (en) * 1981-05-11 1982-11-12 Rhone Poulenc Sante 3-Substd. thio-vinyl 1-oxa-ceph-3-em-4-carboxylic acid antibacterials - esp. having 7-2-2-amino-4-thiazolyl-2-methoxy:imino-acetamido Gp., 3-thio substits. include thiadiazolyl and triazinyl Gps.
FR2509310A1 (en) * 1980-09-25 1983-01-14 Toyama Chemical Co Ltd NEW CEPHALOSPORINS, PROCESS FOR PREPARING THEM AND THEIR THERAPEUTIC APPLICATION
EP0070803A2 (en) * 1981-07-16 1983-01-26 Ciba-Geigy Ag Antibiotically active aminotriazolylcephalosporin derivatives and their preparation
EP0074268A2 (en) * 1981-09-08 1983-03-16 Eli Lilly And Company Improvements in or relating to thieno and furopyridinium-substituted cephalosporin derivatives
FR2514005A1 (en) * 1981-10-02 1983-04-08 Lilly Co Eli CEPHALOSPORINS WITH PYRAZINIUM SUBSTITUTION
EP0076528A2 (en) * 1980-02-18 1983-04-13 Roussel-Uclaf Oxime derivatives of 3-alkyloxy or 3-alkylthiomethyl 7-amino-thiazolylacetamido-cephalosporanic acid and their preparation
EP0076452A2 (en) * 1981-09-30 1983-04-13 Ciba-Geigy Ag Cephalosporin derivatives, process for their preparation and pharmaceutical compositions containing them
EP0091130A2 (en) * 1982-04-06 1983-10-12 Daiichi Seiyaku Co., Ltd. Cephalosporin derivatives, process for preparing and pharmaceutical compositions containing said compounds
FR2530635A1 (en) * 1982-07-23 1984-01-27 Servipharm Ltd AMINO-IMIDAZOLYL COMPOUNDS, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL PREPARATIONS CONTAINING THEM, AND APPLICATION THEREOF
EP0101265A2 (en) * 1982-08-07 1984-02-22 Tanabe Seiyaku Co., Ltd. Novel cephalosporin compounds and preparation thereof
EP0103264A2 (en) * 1982-09-10 1984-03-21 Fujisawa Pharmaceutical Co., Ltd. New cephem compounds and processes for preparation thereof
FR2533216A1 (en) * 1982-09-22 1984-03-23 Toyama Chemical Co Ltd New cephalosporins and their salts.
EP0097961A3 (en) * 1982-06-28 1984-10-03 Bristol-Myers Company Cephalosporin derivatives, a process for the manufacture thereof and pharmaceutical compositions containing said derivatives
EP0122154A2 (en) * 1983-04-12 1984-10-17 Eli Lilly And Company Improvements in or relating to benzothienylglycyl cephalosporin derivatives
EP0122157A2 (en) * 1983-04-12 1984-10-17 Eli Lilly And Company Improvements in or relating to indolylglycyl cephalosporin derivatives
EP0122156A2 (en) * 1983-04-12 1984-10-17 Eli Lilly And Company Improvements in or relating to benzothienylglycyl cephalosporin derivatives
EP0122155A2 (en) * 1983-04-12 1984-10-17 Eli Lilly And Company Improvements in or relating to naphthylglycyl cephalosporin derivatives
EP0135142A2 (en) * 1983-08-25 1985-03-27 Hoechst Aktiengesellschaft Cephalosporin derivatives and process for their preparation
US4521413A (en) * 1981-09-14 1985-06-04 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
EP0147181A2 (en) * 1983-12-21 1985-07-03 Tanabe Seiyaku Co., Ltd. Thiazolylacetic acid derivatives and their preparation
FR2564095A1 (en) * 1984-05-10 1985-11-15 Glaxo Group Ltd ANTIBIOTICS OF CEPHALOSPORINE, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
EP0175610A2 (en) * 1984-09-07 1986-03-26 Meiji Seika Kaisha Ltd. New cephalosporin compounds and the production thereof
EP0186586A2 (en) * 1984-12-20 1986-07-02 Meiji Seika Kaisha Ltd. Cephem compounds and the production thereof

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4079178A (en) * 1971-05-14 1978-03-14 Glaxo Laboratories Limited Cephalosporins having (α-etherified oximino) acylamido groups at the 7-position
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds
US4138555A (en) 1971-05-14 1979-02-06 Glaxo Laboratories, Limited (6R,7R)-7-[2-aryl-2-(etherified oximino)acetamido]-3-carbamoyloxymethylceph-3-em-4-carboxylic acid 1-oxides
US4064346A (en) * 1971-05-14 1977-12-20 Glaxo Laboratories Limited 3-Acetoxymethyl-7β-(2-carboxy-methoxyimino-2-arylacetamido)ceph-3-em-4-carboxylic acids and salts thereof
US4033950A (en) * 1971-05-14 1977-07-05 Glaxo Laboratories Limited 3-Hydroxymethyl-7β-(2-alkoxy-or benzyloxyimino-2-arylacetamido)ceph-3-em-4-carboxylic acids and salts thereof
AR207341A1 (en) * 1973-03-15 1976-09-30 Fujisawa Pharmaceutical Co A PROCEDURE FOR THE PREPARATION OF 2-ALKYL-2 OR 3-CEFEM-4-CARBOXYL ACID DERIVATIVES
US4095021A (en) 1973-12-21 1978-06-13 Glaxo Laboratories Limited 3-Carbamoyloxymethyl or N-methyl-carbamoyloxymethyl-7-[2-carboxymethoxyimino-2-(fur-2-yl or thien-2-yl)acetamido]ceph-3-em-4-carboxylic acids and derivatives thereof
US4144392A (en) 1973-12-21 1979-03-13 Glaxo Laboratories Limited Cephalosporins having at position-7 a carboxy substituted α-etherified hydroxyimino-arylacetamido group and at position-3 the residue of a sulphur nucleophile
IE42144B1 (en) * 1973-12-21 1980-06-18 Glaxo Lab Ltd Improvements in or relating to antibiotics
DK154939C (en) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd METHOD OF ANALOGUE FOR THE PREPARATION OF THIAZOLYLACETAMIDO-CEPHEM COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE SALTS OR ESTERS THEREOF
GB1522140A (en) * 1974-12-20 1978-08-23 Glaxo Lab Ltd Syn-7-(2-hydroxyiminoacetamido)-3-pyridiniummethyl cephalosporins methods for their preparation and compositions containing them
US4200746A (en) 1974-12-20 1980-04-29 Glaxo Laboratories, Ltd. Cephalosporins
NO760358L (en) * 1975-02-04 1976-08-05 Fujisawa Pharmaceutical Co
GB1555471A (en) * 1975-06-19 1979-11-14 Glaxo Lab Ltd 7 carbamoylalkoxyimino acetamido 3 em 4 carboxylic acidsand derivatives thereof
SE440655B (en) * 1976-01-23 1985-08-12 Roussel Uclaf SET TO MAKE NEW OXIME DERIVATIVES OF 7-AMINO-THIAZOLYL-ACETAMIDO-CEPHALOSPORANIC ACID
DE2760123C2 (en) 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporanic acids, their preparation and pharmaceutical compositions containing them
IE44888B1 (en) * 1976-03-09 1982-05-05 Fujisawa Pharmaceutical Co 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation theroef
GB1575803A (en) 1976-03-09 1980-10-01 Fujisawa Pharmaceutical Co 3,7 disubstituted 3 cephem 4 carboxylic acid compounds andprocesses for the preparation thereof
US4165430A (en) 1976-03-19 1979-08-21 Glaxo Laboratories Limited Cephalosporins having a 7-carboxy substituted α-etherified oximinoarylacetamido) group
FR2345153A1 (en) * 1976-03-25 1977-10-21 Roussel Uclaf NEW ALCOYLOXIMES DERIVED FROM 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS
US4166115A (en) * 1976-04-12 1979-08-28 Fujisawa Pharmaceutical Co., Ltd. Syn 7-oxoimino substituted derivatives of cephalosporanic acid
US4066762A (en) * 1976-07-12 1978-01-03 Smithkline Corporation Derivatives of 7-(2-substituted-2-hydroxyiminoacetamido)-3-(1-substituted tetrazol-5-ylthiomethyl-3-cephem-4-carboxylic acid
US4278670A (en) * 1976-07-12 1981-07-14 Smithkline Corporation 7-Alpha-oxyiminoacylcephalosporins
GB1592149A (en) * 1976-10-08 1981-07-01 Fujisawa Pharmaceutical Co 3 7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for preparation thereof
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AT336786B (en) 1977-05-25
YU321379A (en) 1982-02-28
DK155187B (en) 1989-02-27
NO154797B (en) 1986-09-15
DE2223375C2 (en) 1985-05-15
IE38172B1 (en) 1978-01-18
PH11205A (en) 1977-10-28
FR2137900A1 (en) 1972-12-29
YU126772A (en) 1982-02-28
GB1399086A (en) 1975-06-25
ATA420872A (en) 1976-09-15
FR2137900B1 (en) 1976-04-16
ES430104A1 (en) 1976-10-01
CA1027554A (en) 1978-03-07
JPS5328141A (en) 1978-03-16
JPS6324993B2 (en) 1988-05-23
NL166688C (en) 1985-01-16
HK66078A (en) 1978-11-24
JPS531280B1 (en) 1978-01-17
CY971A (en) 1978-12-22
IE38172L (en) 1972-11-14
DE2265234C2 (en) 1983-02-10
IL39429A0 (en) 1972-07-26
NL166688B (en) 1981-04-15
JPS54135792A (en) 1979-10-22
CS245754B2 (en) 1986-10-16
ES402651A1 (en) 1975-11-01
SE457795B (en) 1989-01-30
DE2223375A1 (en) 1972-11-23
CS245753B2 (en) 1986-10-16
MY7800466A (en) 1978-12-31
YU41807B (en) 1988-02-29
IL39429A (en) 1978-04-30
CH591497A5 (en) 1977-09-30
NL7206403A (en) 1972-11-16
DK155187C (en) 1989-07-17
FR2137899B1 (en) 1976-08-20
BE783449A (en) 1972-11-13
KE2895A (en) 1978-11-10
NO154797C (en) 1986-12-29
DE2265234A1 (en) 1976-12-30

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