ES430051A1 - Procedimiento de preparacion de nuevas furo(2,3d)pirimidi- nas. - Google Patents
Procedimiento de preparacion de nuevas furo(2,3d)pirimidi- nas.Info
- Publication number
- ES430051A1 ES430051A1 ES430051A ES430051A ES430051A1 ES 430051 A1 ES430051 A1 ES 430051A1 ES 430051 A ES430051 A ES 430051A ES 430051 A ES430051 A ES 430051A ES 430051 A1 ES430051 A1 ES 430051A1
- Authority
- ES
- Spain
- Prior art keywords
- image
- compounds
- alkyl
- furo
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003230 pyrimidines Chemical class 0.000 title 1
- -1 2,2-dimethyldioxolan-4-yl methyl Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 abstract 1
- 239000002269 analeptic agent Substances 0.000 abstract 1
- 230000003555 analeptic effect Effects 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000001078 anti-cholinergic effect Effects 0.000 abstract 1
- 230000001387 anti-histamine Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000000767 anti-ulcer Effects 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000001631 hypertensive effect Effects 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7335190A FR2245349A1 (en) | 1973-10-02 | 1973-10-02 | Therapeutic furo (2,3-d)-pyrimidine derivs - have anti-ulcer, analgesic, anti-inflammatory, hypertensive etc. activity |
| FR7417484A FR2271823A2 (en) | 1974-05-20 | 1974-05-20 | Therapeutic furo (2,3-d)-pyrimidine derivs - have anti-ulcer, analgesic, anti-inflammatory, hypertensive etc. activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES430051A1 true ES430051A1 (es) | 1976-10-01 |
Family
ID=26217960
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES430051A Expired ES430051A1 (es) | 1973-10-02 | 1974-09-14 | Procedimiento de preparacion de nuevas furo(2,3d)pirimidi- nas. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4007187A (OSRAM) |
| JP (1) | JPS5076091A (OSRAM) |
| CA (1) | CA1015754A (OSRAM) |
| CH (1) | CH592668A5 (OSRAM) |
| DE (1) | DE2446593A1 (OSRAM) |
| ES (1) | ES430051A1 (OSRAM) |
| GB (1) | GB1430720A (OSRAM) |
| LU (1) | LU71010A1 (OSRAM) |
| NL (1) | NL7413033A (OSRAM) |
| SE (1) | SE7412346L (OSRAM) |
| SU (1) | SU581868A3 (OSRAM) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4199584A (en) * | 1977-05-27 | 1980-04-22 | Imperial Chemical Industries Limited | Pesticidal active furo[2,3-d] pyrimidine derivatives, compositions containing the same and use thereof |
| US5137879A (en) * | 1990-03-30 | 1992-08-11 | Dowelanco | Furopyrimidin-4-imine derivatives |
| US6608053B2 (en) * | 2000-04-27 | 2003-08-19 | Yamanouchi Pharmaceutical Co., Ltd. | Fused heteroaryl derivatives |
| DE10148883A1 (de) * | 2001-10-04 | 2003-04-10 | Merck Patent Gmbh | Pyrimidinderivate |
| GB0423653D0 (en) | 2004-10-25 | 2004-11-24 | Piramed Ltd | Pharmaceutical compounds |
| AU2007246793B2 (en) * | 2006-04-26 | 2013-02-07 | F. Hoffmann-La Roche Ag | Thieno [3, 2-D] pyrimidine derivative useful as PI3K inhibitor |
| TW200801012A (en) * | 2006-04-26 | 2008-01-01 | Piramed Ltd | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
| EP2041139B1 (en) | 2006-04-26 | 2011-11-09 | F. Hoffmann-La Roche AG | Pharmaceutical compounds |
| AU2007329352B2 (en) | 2006-12-07 | 2013-01-17 | F. Hoffmann-La Roche Ag | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
| BRPI0717907A2 (pt) * | 2006-12-07 | 2013-11-05 | Genentech Inc | "composto, composição farmacêutica, métodos para tratar um câncer, para inbir ou modular a atividade da lipídeo quinase, processo para a produçãoo de uma composição farmacêutica, uso de um composto e kit" |
| JP5348725B2 (ja) * | 2007-10-25 | 2013-11-20 | ジェネンテック， インコーポレイテッド | チエノピリミジン化合物の製造方法 |
| GB0721095D0 (en) * | 2007-10-26 | 2007-12-05 | Piramed Ltd | Pharmaceutical compounds |
| EP2451811A1 (en) * | 2009-05-27 | 2012-05-16 | F. Hoffmann-La Roche AG | Bicyclic indole-pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use |
| CN102459272B (zh) * | 2009-05-27 | 2014-08-06 | 健泰科生物技术公司 | 对P110δ具有选择性的为PI3K抑制剂的二环嘧啶化合物和使用方法 |
| CA2776944A1 (en) * | 2009-10-12 | 2011-05-12 | F. Hoffmann-La Roche Ag | Combinations of a pi3k inhibitor and a mek inhibitor |
| CN102260270A (zh) * | 2010-05-28 | 2011-11-30 | 中国科学院上海药物研究所 | N-(2-甲基呋喃[2，3-d]嘧啶-4-基)丙烯酰胺、其制备方法及其用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA705417A (en) * | 1965-03-09 | H. Hitchings George | Pyrrolopyrimidine vasodilators and method of making them | |
| US3037980A (en) * | 1955-08-18 | 1962-06-05 | Burroughs Wellcome Co | Pyrrolopyrimidine vasodilators and method of making them |
| GB915303A (en) * | 1958-03-13 | 1963-01-09 | Wellcome Found | Pyrrolo[2,3-d]pyrimidine derivatives and the manufacture thereof |
-
1974
- 1974-08-29 CH CH1177974A patent/CH592668A5/xx not_active IP Right Cessation
- 1974-09-13 GB GB3995074A patent/GB1430720A/en not_active Expired
- 1974-09-14 ES ES430051A patent/ES430051A1/es not_active Expired
- 1974-09-17 US US05/506,826 patent/US4007187A/en not_active Expired - Lifetime
- 1974-09-26 LU LU71010A patent/LU71010A1/xx unknown
- 1974-09-30 DE DE19742446593 patent/DE2446593A1/de active Pending
- 1974-10-01 CA CA210,451A patent/CA1015754A/en not_active Expired
- 1974-10-01 SE SE7412346A patent/SE7412346L/xx unknown
- 1974-10-01 JP JP49113222A patent/JPS5076091A/ja active Pending
- 1974-10-01 SU SU7402063645A patent/SU581868A3/ru active
- 1974-10-02 NL NL7413033A patent/NL7413033A/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU7364874A (en) | 1976-04-01 |
| GB1430720A (en) | 1976-04-07 |
| NL7413033A (nl) | 1975-04-04 |
| CH592668A5 (OSRAM) | 1977-10-31 |
| DE2446593A1 (de) | 1975-04-03 |
| CA1015754A (en) | 1977-08-16 |
| US4007187A (en) | 1977-02-08 |
| SE7412346L (OSRAM) | 1975-04-03 |
| SU581868A3 (ru) | 1977-11-25 |
| JPS5076091A (OSRAM) | 1975-06-21 |
| LU71010A1 (OSRAM) | 1975-06-16 |
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