ES421006A1 - Penicillins their production and their medicinal use - Google Patents
Penicillins their production and their medicinal useInfo
- Publication number
- ES421006A1 ES421006A1 ES421006A ES421006A ES421006A1 ES 421006 A1 ES421006 A1 ES 421006A1 ES 421006 A ES421006 A ES 421006A ES 421006 A ES421006 A ES 421006A ES 421006 A1 ES421006 A1 ES 421006A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- see formula
- alkyl
- amino
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Process for the production of substituted hydroxybenzyl penicillins of general formula I **(See formula)** in which A group (see formula), X is hydrogen, alkyl with up to 10 carbon atoms, alkyl with up to 6 carbon atoms, with one hydrogen atom being from the alkyl group with up to 6 carbon atoms, with one hydrogen atom from the alkyl group being substituted by a nitro, amino, mono to chyl (lower-amino, dialkyl (lower) -amino) group or a 1-pyridinium group; alkenyl with up to 10 carbon atoms, vinyl, cycloalkyl and cycloalkenyl with up to 10 carbon atoms, aryl vinyl, mono-, di- and trihalogeno lower alkyl, mono (lower) -alkyl-amino, dialkyl (lower) -amino, monoarylamino, aryl-lower-alkyl) -amino, alkoxy with up to 8 carbon atoms, cycloalkoxy with up to 7 carbon atoms, aralkoxy with up to 8 carbon atoms, aryloxy, **(See formula)** n is an integer from zero to 2 inclusive and R1, R2 and R3 are each hydrogen, nitro, nitrile, amino, dialkyl (lower) -amino, dialkyl (lower) -aminocarbonyl, alkanoyl (lower) -amino, alkoxy (lower) -carbonyl, lower alkanoyloxy, lower alkyl, lower alkoxy, sulfamyl, chlorine, bromine, iodine, fluorine or trifluoromethyl, Y is alkyl with up to 4 carbon atoms, alkenyl with up to 4 carbon atoms, vinyl, propenyl, cycloalkyl and cycloalkenyl with up to 6 carbon atoms, mono-, di- and trihalogenoalkyl lower, aralkyl with up to 8 carbon atoms or aryl, (see formula) is a bivalent group **(See formula)** G is hydrogen or low molecular weight alkyl with up to 3 carbon atoms, indicating the arrow in the bivalent group (see formula) that in the link of the two free valences of (see formula) with the nitrogen atom and the carbon atom of the group (see formula) must not proceed in any way, but in the form characterized by the arrow, E is oxygen or t'sulfur, B is **(See formula)** and which, as regards the center of chirality C, can be presented in the two possible configurations R and S and as mixtures of the resulting diastomeres, as well as their pharmaceutically tolerable non-toxic salts; characterized in that compounds of the general formula II **(See formula)** in which B and C have the meanings indicated above, they are reacted with compounds of the general formula VI or VII **(See formula)** in which formulas X, Y, Z and E have the meanings indicated above and W represents halogen, acid, a group **(See formula)** (see formula) lower alkyl, in anhydrous or aqueous solvents in the presence of a base at a range temperature of about -20ºC to + 50ºC. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19722258973 DE2258973A1 (en) | 1972-12-01 | 1972-12-01 | PENICILLIN, THE METHOD FOR MANUFACTURING IT AND THEIR USE AS A MEDICINAL PRODUCT |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES421006A1 true ES421006A1 (en) | 1976-07-16 |
Family
ID=5863290
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES421006A Expired ES421006A1 (en) | 1972-12-01 | 1973-11-30 | Penicillins their production and their medicinal use |
| ES444389A Expired ES444389A1 (en) | 1972-12-01 | 1976-01-16 | Penicillins their production and their medicinal use |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES444389A Expired ES444389A1 (en) | 1972-12-01 | 1976-01-16 | Penicillins their production and their medicinal use |
Country Status (20)
| Country | Link |
|---|---|
| JP (2) | JPS4986519A (en) |
| AR (2) | AR200161A1 (en) |
| AU (1) | AU6285673A (en) |
| BE (1) | BE807918A (en) |
| BG (1) | BG20812A3 (en) |
| CH (1) | CH601306A5 (en) |
| DD (1) | DD109221A5 (en) |
| DE (1) | DE2258973A1 (en) |
| EG (1) | EG11062A (en) |
| ES (2) | ES421006A1 (en) |
| FR (1) | FR2208647B1 (en) |
| GB (1) | GB1426199A (en) |
| IE (1) | IE38560B1 (en) |
| IL (1) | IL43708A (en) |
| LU (1) | LU68892A1 (en) |
| NL (1) | NL7316357A (en) |
| PH (1) | PH10188A (en) |
| RO (2) | RO72164A (en) |
| SU (1) | SU523640A3 (en) |
| ZA (1) | ZA739121B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5852996B2 (en) * | 1975-03-25 | 1983-11-26 | バイエル・アクチエンゲゼルシヤフト | Beta-lactams and antibacterial agents |
| DE2658905A1 (en) * | 1976-12-24 | 1978-10-19 | Bayer Ag | BETA-LACTAM-ANTIBIOTICA, METHOD FOR MANUFACTURING IT AND ITS USE AS A MEDICINAL PRODUCT |
| DE2810083A1 (en) | 1978-03-08 | 1979-09-20 | Bayer Ag | BETA-LACTAM COMPOUNDS |
| US4229348A (en) * | 1978-05-26 | 1980-10-21 | Chugai Seiyaku Kabushiki Kaisha | Penicillanic acid derivatives |
| ZA795477B (en) * | 1978-10-16 | 1981-03-25 | Bristol Myers Co | Antibacterial agents |
| JPS5732289A (en) | 1980-08-05 | 1982-02-20 | Chugai Pharmaceut Co Ltd | Alpha-substituted ureidobenzylpenicillin |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE790440A (en) * | 1971-10-23 | 1973-04-24 | Bayer Ag |
-
1972
- 1972-12-01 DE DE19722258973 patent/DE2258973A1/en active Pending
-
1973
- 1973-11-12 PH PH15218A patent/PH10188A/en unknown
- 1973-11-23 AU AU62856/73A patent/AU6285673A/en not_active Expired
- 1973-11-27 IL IL7343708A patent/IL43708A/en unknown
- 1973-11-27 BG BG25084A patent/BG20812A3/xx unknown
- 1973-11-28 BE BE138262A patent/BE807918A/en unknown
- 1973-11-28 RO RO7385228A patent/RO72164A/en unknown
- 1973-11-28 RO RO7376805A patent/RO65197A/en unknown
- 1973-11-29 JP JP48133147A patent/JPS4986519A/ja active Pending
- 1973-11-29 NL NL7316357A patent/NL7316357A/xx not_active Application Discontinuation
- 1973-11-29 DD DD174978A patent/DD109221A5/xx unknown
- 1973-11-29 CH CH1678673A patent/CH601306A5/xx not_active IP Right Cessation
- 1973-11-29 JP JP13314673A patent/JPS576435B2/ja not_active Expired
- 1973-11-29 EG EG452/73A patent/EG11062A/en active
- 1973-11-29 LU LU68892A patent/LU68892A1/xx unknown
- 1973-11-29 SU SU1972067A patent/SU523640A3/en active
- 1973-11-30 AR AR251293A patent/AR200161A1/en active
- 1973-11-30 FR FR7342743A patent/FR2208647B1/fr not_active Expired
- 1973-11-30 IE IE2174/73A patent/IE38560B1/en unknown
- 1973-11-30 ES ES421006A patent/ES421006A1/en not_active Expired
- 1973-11-30 ZA ZA739121A patent/ZA739121B/en unknown
- 1973-11-30 GB GB5566873A patent/GB1426199A/en not_active Expired
-
1974
- 1974-01-01 AR AR255998A patent/AR205450A1/en active
-
1976
- 1976-01-16 ES ES444389A patent/ES444389A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DD109221A5 (en) | 1974-10-20 |
| AR200161A1 (en) | 1974-10-24 |
| NL7316357A (en) | 1974-06-05 |
| FR2208647B1 (en) | 1977-10-28 |
| ZA739121B (en) | 1974-10-30 |
| JPS4986519A (en) | 1974-08-19 |
| SU523640A3 (en) | 1976-07-30 |
| IL43708A (en) | 1977-02-28 |
| EG11062A (en) | 1977-08-15 |
| CH601306A5 (en) | 1978-07-14 |
| PH10188A (en) | 1976-09-23 |
| JPS49116091A (en) | 1974-11-06 |
| RO72164A (en) | 1983-08-03 |
| IE38560B1 (en) | 1978-04-12 |
| GB1426199A (en) | 1976-02-25 |
| DE2258973A1 (en) | 1974-06-06 |
| JPS576435B2 (en) | 1982-02-04 |
| IE38560L (en) | 1974-06-01 |
| LU68892A1 (en) | 1974-02-11 |
| ES444389A1 (en) | 1977-06-01 |
| AU6285673A (en) | 1975-05-29 |
| AR205450A1 (en) | 1976-05-07 |
| FR2208647A1 (en) | 1974-06-28 |
| IL43708A0 (en) | 1974-03-14 |
| RO72164B (en) | 1983-07-30 |
| BE807918A (en) | 1974-05-28 |
| BG20812A3 (en) | 1975-12-20 |
| RO65197A (en) | 1982-09-09 |
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