ES413083A1 - Steroids of the d-homopregnane series - Google Patents

Steroids of the d-homopregnane series

Info

Publication number
ES413083A1
ES413083A1 ES413083A ES413083A ES413083A1 ES 413083 A1 ES413083 A1 ES 413083A1 ES 413083 A ES413083 A ES 413083A ES 413083 A ES413083 A ES 413083A ES 413083 A1 ES413083 A1 ES 413083A1
Authority
ES
Spain
Prior art keywords
series
fluorine
hydrogen
homopregnane
steroids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES413083A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES413083A1 publication Critical patent/ES413083A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B19/00—Oxazine dyes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A procedure for the preparation of pregnane series D-homosteroids of the general formula **(See formula)** in which R6 represents a hydrogen, fluorine or chlorine atom or the methyl group, R9 represents a hydrogen, fluorine, chlorine or bromine atom and R17 and R21 each independently represent a hydroxy or acyloxy group, and its 1,2-dehydro derivatives characterized in that a D-homosteroid of the general formula is hydroxylated at position 11 **(See formula)** or a respective 1,2-dehydro derivative, by means of microorganism or enzymes obtained therefrom. (Machine-translation by Google Translate, not legally binding)
ES413083A 1972-03-29 1973-03-28 Steroids of the d-homopregnane series Expired ES413083A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH466672A CH571018A5 (en) 1972-03-29 1972-03-29

Publications (1)

Publication Number Publication Date
ES413083A1 true ES413083A1 (en) 1976-06-01

Family

ID=4280344

Family Applications (13)

Application Number Title Priority Date Filing Date
ES413083A Expired ES413083A1 (en) 1972-03-29 1973-03-28 Steroids of the d-homopregnane series
ES439952A Expired ES439952A1 (en) 1972-03-29 1975-08-01 Steroids of the d-homopregnane series
ES439959A Expired ES439959A1 (en) 1972-03-29 1975-08-01 Steroids of the d-homopregnane series
ES439953A Expired ES439953A1 (en) 1972-03-29 1975-08-01 Steroids of the d-homopregnane series
ES439957A Expired ES439957A1 (en) 1972-03-29 1975-08-01 Steroids of the d-homopregnane series
ES439955A Expired ES439955A1 (en) 1972-03-29 1975-08-01 Steroids of the d-homopregnane series
ES439954A Expired ES439954A1 (en) 1972-03-29 1975-08-01 Steroids of the d-homopregnane series
ES439949A Expired ES439949A1 (en) 1972-03-29 1975-08-01 Steroids of the d-homopregnane series
ES439956A Expired ES439956A1 (en) 1972-03-29 1975-08-01 Steroids of the d-homopregnane series
ES439951A Expired ES439951A1 (en) 1972-03-29 1975-08-01 Steroids of the d-homopregnane series
ES439948A Expired ES439948A1 (en) 1972-03-29 1975-08-01 Steroids of the d-homopregnane series
ES439958A Expired ES439958A1 (en) 1972-03-29 1975-08-01 Steroids of the d-homopregnane series
ES439950A Expired ES439950A1 (en) 1972-03-29 1975-08-01 Steroids of the d-homopregnane series

Family Applications After (12)

Application Number Title Priority Date Filing Date
ES439952A Expired ES439952A1 (en) 1972-03-29 1975-08-01 Steroids of the d-homopregnane series
ES439959A Expired ES439959A1 (en) 1972-03-29 1975-08-01 Steroids of the d-homopregnane series
ES439953A Expired ES439953A1 (en) 1972-03-29 1975-08-01 Steroids of the d-homopregnane series
ES439957A Expired ES439957A1 (en) 1972-03-29 1975-08-01 Steroids of the d-homopregnane series
ES439955A Expired ES439955A1 (en) 1972-03-29 1975-08-01 Steroids of the d-homopregnane series
ES439954A Expired ES439954A1 (en) 1972-03-29 1975-08-01 Steroids of the d-homopregnane series
ES439949A Expired ES439949A1 (en) 1972-03-29 1975-08-01 Steroids of the d-homopregnane series
ES439956A Expired ES439956A1 (en) 1972-03-29 1975-08-01 Steroids of the d-homopregnane series
ES439951A Expired ES439951A1 (en) 1972-03-29 1975-08-01 Steroids of the d-homopregnane series
ES439948A Expired ES439948A1 (en) 1972-03-29 1975-08-01 Steroids of the d-homopregnane series
ES439958A Expired ES439958A1 (en) 1972-03-29 1975-08-01 Steroids of the d-homopregnane series
ES439950A Expired ES439950A1 (en) 1972-03-29 1975-08-01 Steroids of the d-homopregnane series

Country Status (27)

Country Link
JP (2) JPS5844360B2 (en)
KR (3) KR780000672B1 (en)
AR (1) AR208389A1 (en)
AT (1) AT326282B (en)
AU (1) AU468918B2 (en)
BE (1) BE797412A (en)
CA (1) CA1006156A (en)
CH (1) CH571018A5 (en)
DD (1) DD105216A5 (en)
DE (1) DE2314592C2 (en)
DK (1) DK135722B (en)
ES (13) ES413083A1 (en)
FI (1) FI52099C (en)
FR (1) FR2182911B1 (en)
GB (1) GB1365469A (en)
HU (2) HU166580B (en)
IE (1) IE37444B1 (en)
IL (1) IL41752A (en)
LU (1) LU67304A1 (en)
NL (1) NL176945C (en)
NO (1) NO139524C (en)
PH (1) PH9660A (en)
PL (7) PL98710B1 (en)
SE (2) SE404530B (en)
SU (7) SU492080A3 (en)
YU (4) YU35775B (en)
ZA (1) ZA731563B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK142289B (en) * 1973-03-28 1980-10-06 Hoffmann La Roche Analogous procedure for the preparation of D-homopregn-4-ene-3,20-dione.
DE2442615A1 (en) * 1974-09-04 1976-03-18 Schering Ag NEW D-HOMO-STEROIDS
SE411351B (en) * 1974-10-07 1979-12-17 Hoffmann La Roche PROCEDURE FOR THE PREPARATION OF D-HOMOSTEROIDS FROM THE PREGNANCY SERIES
SE427276B (en) * 1975-04-03 1983-03-21 Hoffmann La Roche PROCEDURE FOR PREPARING D-HOMOSTEROIDS
AT356301B (en) * 1976-09-03 1980-04-25 Hoffmann La Roche METHOD FOR THE PRODUCTION OF NEW D-HOMOSTEROIDS
US4202841A (en) * 1977-08-25 1980-05-13 Hoffmann-La Roche Inc. D-Homopregnanes
DE3038855A1 (en) * 1980-10-10 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen NEW D-HOMO CORTICOIDS, THEIR PRODUCTION AND USE
DE3409554A1 (en) * 1984-03-13 1985-09-19 Schering AG, 1000 Berlin und 4709 Bergkamen NEW 6 (ALPHA) METHYL-D HOMO CORTICOIDS
JPH0356125Y2 (en) * 1985-07-30 1991-12-16

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2860158A (en) * 1954-10-18 1958-11-11 Sterling Drug Inc Compounds of the perhydrochrysene series and preparation thereof

Also Published As

Publication number Publication date
ES439951A1 (en) 1977-07-01
GB1365469A (en) 1974-09-04
SU697054A3 (en) 1979-11-05
AT326282B (en) 1975-12-10
PL92076B1 (en) 1977-03-31
YU81573A (en) 1980-12-31
JPS5877899A (en) 1983-05-11
IL41752A0 (en) 1973-05-31
IE37444L (en) 1973-09-29
ES439952A1 (en) 1977-07-01
ES439948A1 (en) 1977-07-01
HU170428B (en) 1977-06-28
SU612636A3 (en) 1978-06-25
NL7304193A (en) 1973-10-02
ES439950A1 (en) 1977-07-01
YU35775B (en) 1981-06-30
YU35452B (en) 1981-02-28
NO139524B (en) 1978-12-18
HU166580B (en) 1975-04-28
SU538665A3 (en) 1976-12-05
KR780000673B1 (en) 1978-12-26
SU506288A3 (en) 1976-03-05
PH9660A (en) 1976-01-27
NO139524C (en) 1979-03-28
ES439956A1 (en) 1977-06-01
DE2314592C2 (en) 1983-04-14
DK135722B (en) 1977-06-13
SU517263A3 (en) 1976-06-05
IE37444B1 (en) 1977-07-20
ES439957A1 (en) 1977-06-01
PL98712B1 (en) 1978-05-31
AU468918B2 (en) 1976-01-29
ZA731563B (en) 1973-11-28
PL92130B1 (en) 1977-03-31
DK135722C (en) 1977-11-14
YU35453B (en) 1981-02-28
ES439953A1 (en) 1977-06-16
SE7602850L (en) 1976-02-27
PL98710B1 (en) 1978-05-31
NL176945C (en) 1985-07-01
SU509211A3 (en) 1976-03-30
KR780000672B1 (en) 1978-12-26
AU5320773A (en) 1974-09-12
ES439959A1 (en) 1977-06-01
JPS6052160B2 (en) 1985-11-18
IL41752A (en) 1977-11-30
LU67304A1 (en) 1974-10-09
SU492080A3 (en) 1975-11-15
JPS495960A (en) 1974-01-19
CA1006156A (en) 1977-03-01
SE404530B (en) 1978-10-09
DD105216A5 (en) 1974-04-12
FR2182911A1 (en) 1973-12-14
DE2314592A1 (en) 1973-10-11
NL176945B (en) 1985-02-01
ES439958A1 (en) 1977-06-01
PL98714B1 (en) 1978-05-31
ES439954A1 (en) 1977-06-01
YU56879A (en) 1980-09-25
FI52099C (en) 1977-06-10
PL86797B1 (en) 1976-06-30
ES439955A1 (en) 1977-06-01
FR2182911B1 (en) 1976-10-22
CH571018A5 (en) 1975-12-31
KR780000675B1 (en) 1978-12-26
ES439949A1 (en) 1977-07-01
YU56979A (en) 1980-09-25
ATA270973A (en) 1975-02-15
AR208389A1 (en) 1976-12-27
FI52099B (en) 1977-02-28
PL92077B1 (en) 1977-03-31
BE797412A (en) 1973-09-28
JPS5844360B2 (en) 1983-10-03

Similar Documents

Publication Publication Date Title
ES421253A1 (en) Novel 11,11-alkylidene steroids
BG37075A3 (en) Method for preparing derivatives of proline
ES414411A1 (en) Procedure for the preparation of steroids of the pregnan or 19-norpregnan series. (Machine-translation by Google Translate, not legally binding)
ES413083A1 (en) Steroids of the d-homopregnane series
GB1092145A (en) Microbiological conversion of steroids
BG33585A3 (en) A NEW METHOD OF OBTAINING AZINES
GR37269B (en) METHOD FOR THE MANUFACTURE OF 17-UNSATURED HYDROGENETHEL-SUBSTITUTED 11,13B-DIALKYLOGEN-4-ENO-3,17B-DIOLS AND THESE ESTERS.
ES403723A2 (en) A procedure for the preparation of steroids of the pregnan series (Machine-translation by Google Translate, not legally binding)
CA1266641C (en) 16-keto-17-substituted thia-17-alkyl (or alkenyl or alkynyl) androstenes
BG33735A3 (en) METHOD FOR PREPARING 17-POSITION SUBSTITUTED STEROIDS OF THE PREGNANE SERIES
ES435204A1 (en) 11{62 -fluoroandrostenes
ES423716A1 (en) 1-Oxo-hexahydroacridines
ES449642A1 (en) 21-acetals and mixed acetals of steroidal 21-aldehydes, intermediates and methods of preparation
ES388784A1 (en) Novel preparation of pregnanes
ES368164A1 (en) Aldehydes of the pregnane series and process for their manufacture
ES382098A1 (en) 14beta-hydroxy-15alpha-acyloxy-cardenolides
BG29134A3 (en) Method of obtaining of 4- bromphenylcarbamide derivatives
ES360861A1 (en) Procedure for the preparation of new derivatives of tiazepine. (Machine-translation by Google Translate, not legally binding)
GB1038524A (en) 1-dehydro steroids
ES418731A1 (en) Procedure for preparing nitro-2 benzofuran derivatives. (Machine-translation by Google Translate, not legally binding)
FR1261181A (en) Production by fermentation of 11 alpha-hydroxyl derivatives of steroids of the 16 alpha-alkyl-4-pregnene-3, 20-dione series
BG28710A3 (en) Method of obtaining of morpholine derivatives
ES387315A1 (en) Procedure for the obtaining of 17-monosteres of dihydroxylated steroids in c17 and c21. (Machine-translation by Google Translate, not legally binding)
ES465550A1 (en) Procedure for the obtaining of halogenopregnadienos. (Machine-translation by Google Translate, not legally binding)
GB763947A (en) Improved etiocholanic acid derivatives and methods for their production