ES410248A1 - Halogenated phenylthioacetamide cephalosporanic acids - Google Patents
Halogenated phenylthioacetamide cephalosporanic acidsInfo
- Publication number
- ES410248A1 ES410248A1 ES410248A ES410248A ES410248A1 ES 410248 A1 ES410248 A1 ES 410248A1 ES 410248 A ES410248 A ES 410248A ES 410248 A ES410248 A ES 410248A ES 410248 A1 ES410248 A1 ES 410248A1
- Authority
- ES
- Spain
- Prior art keywords
- chlorine
- hydrogen
- halogenated
- phenylthioacetamide
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 title abstract 3
- 150000007513 acids Chemical class 0.000 title abstract 2
- CJXBHFANXQMZBF-UHFFFAOYSA-N 2-phenylethanethioamide Chemical class NC(=S)CC1=CC=CC=C1 CJXBHFANXQMZBF-UHFFFAOYSA-N 0.000 title 1
- 229910052801 chlorine Chemical group 0.000 abstract 6
- 239000000460 chlorine Chemical group 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 3
- 150000008064 anhydrides Chemical class 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- HSHGZXNAXBPPDL-HZGVNTEJSA-N 7beta-aminocephalosporanic acid Chemical compound S1CC(COC(=O)C)=C(C([O-])=O)N2C(=O)[C@@H]([NH3+])[C@@H]12 HSHGZXNAXBPPDL-HZGVNTEJSA-N 0.000 abstract 1
- XBPCUCUWBYBCDP-UHFFFAOYSA-N Dicyclohexylamine Chemical compound C1CCCCC1NC1CCCCC1 XBPCUCUWBYBCDP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001266 acyl halides Chemical class 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
- C08J9/0061—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof characterized by the use of several polymeric components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
- C07D501/28—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by an aliphatic carboxylic acid, which is substituted by hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/40—High-molecular-weight compounds
- C08G18/4009—Two or more macromolecular compounds not provided for in one single group of groups C08G18/42 - C08G18/64
- C08G18/4072—Mixtures of compounds of group C08G18/63 with other macromolecular compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/42—Block-or graft-polymers containing polysiloxane sequences
- C08G77/46—Block-or graft-polymers containing polysiloxane sequences containing polyether sequences
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2375/00—Characterised by the use of polyureas or polyurethanes; Derivatives of such polymers
- C08J2375/04—Polyurethanes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2483/00—Characterised by the use of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen, or carbon only; Derivatives of such polymers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Cephalosporin Compounds (AREA)
- Polyurethanes Or Polyureas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
- Silicon Polymers (AREA)
Abstract
A process for the preparation of halogenated phenylthioacetamido-cephalosporanic acids of general formula ** (See formula) ** where R is ** (See formula) ** where R1 is fluorine or chlorine and when R1 is fluorine, R2 and R4 are hydrogen or chlorine and R3 is hydrogen and when R1 is chlorine a) R2 is hydrogen and one of the radicals R3 or R4 is chlorine, the other being hydrogen or b) R2 is chlorine and R3 and R4 are hydrogen or chlorine and R'is hydrogen, dicyclohexylamine or a pharmaceutically acceptable cation, which process is characterized by acylating 7-aminocephalosporanic acid with an acid of formula ** (See formula) ** or the corresponding anhydride, mixed anhydride, or acyl halide. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21273971A | 1971-12-27 | 1971-12-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES410248A1 true ES410248A1 (en) | 1976-04-01 |
Family
ID=22792241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES410248A Expired ES410248A1 (en) | 1971-12-27 | 1972-12-27 | Halogenated phenylthioacetamide cephalosporanic acids |
Country Status (19)
| Country | Link |
|---|---|
| JP (2) | JPS4885592A (en) |
| AR (1) | AR195312A1 (en) |
| AT (1) | AT322107B (en) |
| AU (2) | AU463521B2 (en) |
| BE (1) | BE793310A (en) |
| CA (1) | CA986099A (en) |
| CH (1) | CH558383A (en) |
| DE (1) | DE2263430C2 (en) |
| ES (1) | ES410248A1 (en) |
| FR (1) | FR2166080B1 (en) |
| GB (1) | GB1405798A (en) |
| HU (1) | HU167747B (en) |
| IE (1) | IE37028B1 (en) |
| IL (1) | IL41161A (en) |
| NL (1) | NL7217699A (en) |
| PH (1) | PH13639A (en) |
| SE (1) | SE417209B (en) |
| YU (1) | YU36043B (en) |
| ZA (2) | ZA729115B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6329363B1 (en) | 1997-12-12 | 2001-12-11 | Eli Lilly And Company | Cephalosporin antibiotics |
| DE102006061351A1 (en) * | 2006-12-22 | 2008-06-26 | Evonik Goldschmidt Gmbh | Process for the preparation of SiOC-linked, linear polydimethylsiloxane-polyoxyalkylene block copolymers and their use |
| JP4954845B2 (en) * | 2007-11-05 | 2012-06-20 | 瑞乾 高 | Holder for hand tools |
| EP3608719A4 (en) | 2017-04-04 | 2020-04-22 | Asahi Kasei Kabushiki Kaisha | Photosensitive resin composition for flexographic printing plate, flexographic printing original plate, flexographic printing plate, and copolymer |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1321704A (en) * | 1962-04-03 | 1963-03-22 | Lilly Co Eli | Process for preparing 7- (s-substituted mercapto-acylamido) derivatives of cephalosporins c and novel compounds thus prepared |
| US3335136A (en) * | 1965-12-27 | 1967-08-08 | Lilly Co Eli | Halophenylmercaptomethyl cephalosporins |
-
0
- BE BE793310D patent/BE793310A/en unknown
-
1972
- 1972-12-20 CA CA159,573A patent/CA986099A/en not_active Expired
- 1972-12-21 GB GB5898872A patent/GB1405798A/en not_active Expired
- 1972-12-22 SE SE7216889A patent/SE417209B/en unknown
- 1972-12-25 IL IL41161A patent/IL41161A/en unknown
- 1972-12-27 CH CH1888872A patent/CH558383A/en not_active IP Right Cessation
- 1972-12-27 YU YU3246/72A patent/YU36043B/en unknown
- 1972-12-27 ES ES410248A patent/ES410248A1/en not_active Expired
- 1972-12-27 AR AR245876A patent/AR195312A1/en active
- 1972-12-27 DE DE2263430A patent/DE2263430C2/en not_active Expired
- 1972-12-27 HU HUEI454A patent/HU167747B/hu unknown
- 1972-12-27 ZA ZA729115A patent/ZA729115B/en unknown
- 1972-12-27 JP JP48004225A patent/JPS4885592A/ja active Pending
- 1972-12-27 AT AT1104672A patent/AT322107B/en not_active IP Right Cessation
- 1972-12-27 ZA ZA729116A patent/ZA729116B/en unknown
- 1972-12-27 PH PH14208A patent/PH13639A/en unknown
- 1972-12-27 NL NL7217699A patent/NL7217699A/xx active Search and Examination
- 1972-12-27 FR FR7246412A patent/FR2166080B1/fr not_active Expired
- 1972-12-28 IE IE1792/72A patent/IE37028B1/en unknown
- 1972-12-28 AU AU50544/72A patent/AU463521B2/en not_active Expired
- 1972-12-28 AU AU50543/72A patent/AU466218B2/en not_active Expired
-
1974
- 1974-12-25 JP JP14823274A patent/JPS541840B2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU5054372A (en) | 1974-07-04 |
| CA986099A (en) | 1976-03-23 |
| AU5054472A (en) | 1974-07-04 |
| AT322107B (en) | 1975-05-12 |
| HU167747B (en) | 1975-12-25 |
| IL41161A0 (en) | 1973-02-28 |
| DE2263430C2 (en) | 1983-09-22 |
| FR2166080B1 (en) | 1977-01-28 |
| SE417209B (en) | 1981-03-02 |
| YU324672A (en) | 1981-02-28 |
| FR2166080A1 (en) | 1973-08-10 |
| AU466218B2 (en) | 1975-10-23 |
| JPS541840B2 (en) | 1979-01-30 |
| JPS4885592A (en) | 1973-11-13 |
| AR195312A1 (en) | 1973-09-28 |
| AU463521B2 (en) | 1975-07-31 |
| ZA729115B (en) | 1974-08-28 |
| BE793310A (en) | 1973-06-27 |
| GB1405798A (en) | 1975-09-10 |
| NL7217699A (en) | 1973-06-29 |
| PH13639A (en) | 1980-08-18 |
| YU36043B (en) | 1981-11-13 |
| IE37028B1 (en) | 1977-04-13 |
| JPS50105996A (en) | 1975-08-21 |
| IE37028L (en) | 1973-06-27 |
| DE2263430A1 (en) | 1973-07-05 |
| IL41161A (en) | 1975-10-15 |
| ZA729116B (en) | 1974-08-28 |
| CH558383A (en) | 1975-01-31 |
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