ES410249A1 - Halophenylthioacetamide cephalosporin derivatives - Google Patents

Halophenylthioacetamide cephalosporin derivatives

Info

Publication number
ES410249A1
ES410249A1 ES410249A ES410249A ES410249A1 ES 410249 A1 ES410249 A1 ES 410249A1 ES 410249 A ES410249 A ES 410249A ES 410249 A ES410249 A ES 410249A ES 410249 A1 ES410249 A1 ES 410249A1
Authority
ES
Spain
Prior art keywords
hydrogen
formula
chlorine
phenyl ring
chlorine atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES410249A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES410249A1 publication Critical patent/ES410249A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/4009—Two or more macromolecular compounds not provided for in one single group of groups C08G18/42 - C08G18/64
    • C08G18/4072—Mixtures of compounds of group C08G18/63 with other macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/42—Block-or graft-polymers containing polysiloxane sequences
    • C08G77/46—Block-or graft-polymers containing polysiloxane sequences containing polyether sequences
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/0061—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof characterized by the use of several polymeric components
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2375/00—Characterised by the use of polyureas or polyurethanes; Derivatives of such polymers
    • C08J2375/04—Polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2483/00—Characterised by the use of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen, or carbon only; Derivatives of such polymers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

A process for the preparation of halofenylthioacetamidocephalosporin derivatives of the formula: ** (see formula) ** Where z is hydrogen or fluorine, and when z is hydrogen x and y are hydrogen or chlorine, selected so that the phenyl ring is substituted with one or two chlorine atoms and so that when a single chlorine atom is present, it is in position 3 and when two chlorine atoms are present, they are in positions 3,4, 3,5 or 2,5; and when z is fluorine it is in the 3 or 4 position of the phenyl ring, and each of x and y is hydrogen or chlorine, so that when the phenyl ring is substituted with one or two chlorine atoms, one of which is in the 3 or 4 positions of the phenyl ring; R is hydrogen, 5-methyl-1,3,4-tiadiazolyl-2-tio, 1-methyl-5-tetrazolylthio, 1H-tetrazol-5-ylt, 5-phenyl-1,3,4-oxyadiazolyl-2- that, 5- (p-nitrofenyl) -1,3,4-oxadiazolyl-2-tio, 5- (p-methoxyphenyl) -1,3,4-oxadiazolyl-2-thio, carbamethoxy, methylcarbamoyloxy, thiomethyl, pyridine, azide or dithycarbamoyl and R'is hydrogen, dicyclohexylamine or a pharmaceutically acceptable cation; Whose procedure is characterized by: A) N-acylate a compound of formula ** (see formula) ** Where r and r'have the meaning defined above, with an acylating agent comprising an acid of formula ** (see formula) ** Or the corresponding acyl halide, anhydride or mixed anhydride, wherein x, y and z have the meaning given above; and optionally preparing the salts thereof. (Machine-translation by Google Translate, not legally binding)
ES410249A 1971-12-27 1972-12-27 Halophenylthioacetamide cephalosporin derivatives Expired ES410249A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21273971A 1971-12-27 1971-12-27
US28822772A 1972-09-11 1972-09-11

Publications (1)

Publication Number Publication Date
ES410249A1 true ES410249A1 (en) 1976-04-01

Family

ID=26907406

Family Applications (2)

Application Number Title Priority Date Filing Date
ES410249A Expired ES410249A1 (en) 1971-12-27 1972-12-27 Halophenylthioacetamide cephalosporin derivatives
ES438108A Expired ES438108A1 (en) 1971-12-27 1975-05-31 Halophenylthioacetamide cephalosporin derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES438108A Expired ES438108A1 (en) 1971-12-27 1975-05-31 Halophenylthioacetamide cephalosporin derivatives

Country Status (17)

Country Link
JP (1) JPS4885593A (en)
AR (1) AR201736A1 (en)
AT (2) AT325202B (en)
BE (1) BE793311A (en)
CA (1) CA1017325A (en)
CH (2) CH555365A (en)
DE (1) DE2263439C2 (en)
ES (2) ES410249A1 (en)
FR (1) FR2166081A1 (en)
GB (1) GB1405797A (en)
HU (1) HU166211B (en)
IE (1) IE37029B1 (en)
IL (1) IL41162A (en)
NL (1) NL7217698A (en)
PH (1) PH9252A (en)
SE (1) SE417208B (en)
YU (1) YU37494B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6329363B1 (en) 1997-12-12 2001-12-11 Eli Lilly And Company Cephalosporin antibiotics

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1321704A (en) * 1962-04-03 1963-03-22 Lilly Co Eli Process for preparing 7- (s-substituted mercapto-acylamido) derivatives of cephalosporins c and novel compounds thus prepared
US3335136A (en) * 1965-12-27 1967-08-08 Lilly Co Eli Halophenylmercaptomethyl cephalosporins
JPS4849789A (en) * 1971-10-25 1973-07-13

Also Published As

Publication number Publication date
ATA161374A (en) 1975-02-15
IL41162A0 (en) 1973-02-28
ES438108A1 (en) 1977-05-16
YU324572A (en) 1981-08-31
IE37029L (en) 1973-06-27
HU166211B (en) 1975-02-28
SE417208B (en) 1981-03-02
IL41162A (en) 1975-08-31
JPS4885593A (en) 1973-11-13
CH581662A5 (en) 1976-11-15
GB1405797A (en) 1975-09-10
FR2166081B1 (en) 1976-04-23
NL7217698A (en) 1973-06-29
AT325202B (en) 1975-10-10
CA1017325A (en) 1977-09-13
DE2263439A1 (en) 1973-07-12
BE793311A (en) 1973-06-27
AT326269B (en) 1975-12-10
PH9252A (en) 1975-07-30
DE2263439C2 (en) 1984-07-19
YU37494B (en) 1984-08-31
IE37029B1 (en) 1977-04-13
AR201736A1 (en) 1975-04-15
FR2166081A1 (en) 1973-08-10
CH555365A (en) 1974-10-31

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