IE37029L - 7-halophenylthioacetamido cephalosporins - Google Patents
7-halophenylthioacetamido cephalosporinsInfo
- Publication number
- IE37029L IE37029L IE721793A IE179372A IE37029L IE 37029 L IE37029 L IE 37029L IE 721793 A IE721793 A IE 721793A IE 179372 A IE179372 A IE 179372A IE 37029 L IE37029 L IE 37029L
- Authority
- IE
- Ireland
- Prior art keywords
- methyl
- tetrazolylthio
- thio
- reacting
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/40—High-molecular-weight compounds
- C08G18/4009—Two or more macromolecular compounds not provided for in one single group of groups C08G18/42 - C08G18/64
- C08G18/4072—Mixtures of compounds of group C08G18/63 with other macromolecular compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/42—Block-or graft-polymers containing polysiloxane sequences
- C08G77/46—Block-or graft-polymers containing polysiloxane sequences containing polyether sequences
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
- C08J9/0061—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof characterized by the use of several polymeric components
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2375/00—Characterised by the use of polyureas or polyurethanes; Derivatives of such polymers
- C08J2375/04—Polyurethanes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2483/00—Characterised by the use of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen, or carbon only; Derivatives of such polymers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Title cpds. (I): where X and Y are H or Cl (1 or 2 Cl if 1 it is at 3, if 2 they are at 3, 4, 3, 5 or 2,5) Z is H or F, (if F it is at 3 or 4, either as sole substit. or with 1 or 2 Cl atoms, 1 of which it is at 3 or 4), R is H, 5-methyl-1,3,4-thiadiazolyl-2-thio, 1-methyl-5-tetrazolylthio, 2-tetrazolylthio, 5-phenyl/p-nitro-phenyl/p-methoxyphenyl-1,3,4-oxadiazolyl-2-thio, (methyl)carbamyloxy, MeS, N-pyridino, azido or dithiocarbamoyl, R1 is H, dicyclohexylamine or a pharmaceutically acceptable cation) are prepd. by reacting a 7-aminocephalosporanic acid deriv. with a reactive deriv. of an appropriate acid or by reacting (I, R = OAc) with a heterocyclic thiol, MeSH, pyridine, alkali metal azide or dithiocarbamate. A prefd. cpd. is 7-(3', 4'-dichlorophenylthioacetamido)-3-(1'-methyltetrazol)-5-yl-thiome- thyl)-3-cephem-4-carboxylic acid.
[FR2166081A1]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21273971A | 1971-12-27 | 1971-12-27 | |
| US28822772A | 1972-09-11 | 1972-09-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE37029L true IE37029L (en) | 1973-06-27 |
| IE37029B1 IE37029B1 (en) | 1977-04-13 |
Family
ID=26907406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1793/72A IE37029B1 (en) | 1971-12-27 | 1972-12-28 | Halophenylthioacetamide cephalosporin derivatives |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS4885593A (en) |
| AR (1) | AR201736A1 (en) |
| AT (2) | AT325202B (en) |
| BE (1) | BE793311A (en) |
| CA (1) | CA1017325A (en) |
| CH (2) | CH581662A5 (en) |
| DE (1) | DE2263439C2 (en) |
| ES (2) | ES410249A1 (en) |
| FR (1) | FR2166081A1 (en) |
| GB (1) | GB1405797A (en) |
| HU (1) | HU166211B (en) |
| IE (1) | IE37029B1 (en) |
| IL (1) | IL41162A (en) |
| NL (1) | NL7217698A (en) |
| PH (1) | PH9252A (en) |
| SE (1) | SE417208B (en) |
| YU (1) | YU37494B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6329363B1 (en) | 1997-12-12 | 2001-12-11 | Eli Lilly And Company | Cephalosporin antibiotics |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1321704A (en) * | 1962-04-03 | 1963-03-22 | Lilly Co Eli | Process for preparing 7- (s-substituted mercapto-acylamido) derivatives of cephalosporins c and novel compounds thus prepared |
| US3335136A (en) * | 1965-12-27 | 1967-08-08 | Lilly Co Eli | Halophenylmercaptomethyl cephalosporins |
| JPS4849789A (en) * | 1971-10-25 | 1973-07-13 |
-
1972
- 1972-12-20 CA CA159,574A patent/CA1017325A/en not_active Expired
- 1972-12-21 GB GB5898772A patent/GB1405797A/en not_active Expired
- 1972-12-22 SE SE7216890A patent/SE417208B/en unknown
- 1972-12-25 IL IL41162A patent/IL41162A/en unknown
- 1972-12-27 CH CH1060774A patent/CH581662A5/xx not_active IP Right Cessation
- 1972-12-27 YU YU3245/72A patent/YU37494B/en unknown
- 1972-12-27 JP JP48004226A patent/JPS4885593A/ja active Pending
- 1972-12-27 HU HUEI453A patent/HU166211B/hu unknown
- 1972-12-27 AT AT1104772A patent/AT325202B/en not_active IP Right Cessation
- 1972-12-27 DE DE2263439A patent/DE2263439C2/en not_active Expired
- 1972-12-27 FR FR7246413A patent/FR2166081A1/en active Granted
- 1972-12-27 ES ES410249A patent/ES410249A1/en not_active Expired
- 1972-12-27 PH PH14207*UA patent/PH9252A/en unknown
- 1972-12-27 AR AR245877A patent/AR201736A1/en active
- 1972-12-27 CH CH1889272A patent/CH555365A/en not_active IP Right Cessation
- 1972-12-27 BE BE793311D patent/BE793311A/en not_active IP Right Cessation
- 1972-12-27 NL NL7217698A patent/NL7217698A/xx active Search and Examination
- 1972-12-28 IE IE1793/72A patent/IE37029B1/en unknown
-
1974
- 1974-02-27 AT AT161374*1A patent/AT326269B/en not_active IP Right Cessation
-
1975
- 1975-05-31 ES ES438108A patent/ES438108A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IE37029B1 (en) | 1977-04-13 |
| SE417208B (en) | 1981-03-02 |
| DE2263439C2 (en) | 1984-07-19 |
| YU37494B (en) | 1984-08-31 |
| CH581662A5 (en) | 1976-11-15 |
| IL41162A (en) | 1975-08-31 |
| ES410249A1 (en) | 1976-04-01 |
| BE793311A (en) | 1973-06-27 |
| AT325202B (en) | 1975-10-10 |
| FR2166081A1 (en) | 1973-08-10 |
| FR2166081B1 (en) | 1976-04-23 |
| PH9252A (en) | 1975-07-30 |
| AR201736A1 (en) | 1975-04-15 |
| YU324572A (en) | 1981-08-31 |
| JPS4885593A (en) | 1973-11-13 |
| AT326269B (en) | 1975-12-10 |
| HU166211B (en) | 1975-02-28 |
| ATA161374A (en) | 1975-02-15 |
| GB1405797A (en) | 1975-09-10 |
| ES438108A1 (en) | 1977-05-16 |
| IL41162A0 (en) | 1973-02-28 |
| CH555365A (en) | 1974-10-31 |
| NL7217698A (en) | 1973-06-29 |
| DE2263439A1 (en) | 1973-07-12 |
| CA1017325A (en) | 1977-09-13 |
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