ES402140A1 - Orally applicable contrast agents for cholecystography - Google Patents
Orally applicable contrast agents for cholecystographyInfo
- Publication number
- ES402140A1 ES402140A1 ES402140A ES402140A ES402140A1 ES 402140 A1 ES402140 A1 ES 402140A1 ES 402140 A ES402140 A ES 402140A ES 402140 A ES402140 A ES 402140A ES 402140 A1 ES402140 A1 ES 402140A1
- Authority
- ES
- Spain
- Prior art keywords
- radical
- alkyl
- group
- see formula
- triiodo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0495—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound intended for oral administration
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Procedure for the preparation of the new 3 - [(3-carbamoyl-2,4,6-triiodo-phenoxy) -alkoxy] -2-alkyl-propionic acids capable of being used as shade providing components in ray contrast agents x of the general formula ** (see formula) ** In which alkyl means a lower alkyl group with 1 to a maximum of 4 carbon atoms, but the radical ** (see formula) ** Also means morpholino, piperidino or pyrrolidino group, n means an integer of 2, 3 or 4, and a means the methyl, ethyl, propyl or butyl radical, as well as their physiologically compatible physiological and metal salts, characterized in that ether 3-carbamoyl-2,4,6-triiodo-phenol of the general formula ** (see formula) ** In which alkyl means a lower alkyl group with 1 up to a maximum of 4 carbon atoms, but the radical ** (see formula) ** Also means a morpholino, piperidino, or pyrrolidino group, by reaction with a 3-alkoxy-2-alkyl-propionic acid derivative capable of reacting of the general formula ** (see formula) ** Wherein x means the reactive radical of a strong acid, therefore a halogen, chloro, bromo or iodo radical, or a radical sulfate or sulfonate, n means an integer of 2.3 or 4, a, means a group methyl, ethyl, propyl or butyl and -coor'means a carboxylic acid ester group or a carboxylate group, and subsequently the corresponding acid 3 - [(3-carbamoyl-2,4,6-triiodo-phenoxy) - is isolated alkoxy] -2-alkyl-propionic and eventually it is transformed into its salts. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH914771 | 1971-06-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES402140A1 true ES402140A1 (en) | 1975-03-01 |
Family
ID=4348851
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES402140A Expired ES402140A1 (en) | 1971-06-23 | 1972-04-26 | Orally applicable contrast agents for cholecystography |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US3825591A (en) |
| JP (1) | JPS529666B1 (en) |
| AT (2) | AT315150B (en) |
| AU (1) | AU461847B2 (en) |
| BE (1) | BE785109R (en) |
| BG (1) | BG20336A3 (en) |
| BR (1) | BR7204002D0 (en) |
| CA (1) | CA957371A (en) |
| CH (1) | CH545628A (en) |
| CS (1) | CS182769B2 (en) |
| DD (1) | DD95912A5 (en) |
| DE (1) | DE2212741C3 (en) |
| DK (1) | DK128108B (en) |
| ES (1) | ES402140A1 (en) |
| FI (1) | FI53660C (en) |
| FR (1) | FR2142986B1 (en) |
| HU (1) | HU163382B (en) |
| IL (1) | IL39329A (en) |
| IT (1) | IT7921397A0 (en) |
| NL (1) | NL157798B (en) |
| PH (1) | PH10571A (en) |
| PL (1) | PL90341B1 (en) |
| RO (1) | RO68261A (en) |
| SE (1) | SE391178B (en) |
| SU (1) | SU451237A3 (en) |
| ZA (1) | ZA723058B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3164618D1 (en) | 1980-12-22 | 1984-08-09 | Schering Ag | 3-substituted 2,4,6-trihalogenobenzamides and their salts, their preparation and their use as substitutes for natural sweetening agents, and sweeteners containing them |
| US5316755A (en) * | 1993-02-02 | 1994-05-31 | Sterling Winthrop Inc. | Compositions of iodophenoxy alkanes and iodophenyl ethers for visualization of the gastrointestinal tract |
| US5326553A (en) * | 1993-02-02 | 1994-07-05 | Sterling Winthrop Inc. | Compositions of iodophenoxy alkanes and iodophenyl ethers in film-forming materials for visualization of the gastrointestinal tract |
| US5308607A (en) * | 1993-02-04 | 1994-05-03 | Sterling Winthrop Inc. | Compositions of alkylbenzenes for visualization of the gastrointestinal tract using X-ray contrast |
| US5348727A (en) * | 1993-03-11 | 1994-09-20 | Sterling Winthrop Inc. | Compositions of iodophenoxy alkylene ethers for visualization of the gastrointestinal tract |
| US5492687A (en) * | 1993-03-11 | 1996-02-20 | Sterling Winthrop Inc. | Compositions of iodophenoxy alkylene ethers and pharmaceutically acceptable clays for visualization of the gastrointestinal tract |
| US5310538A (en) * | 1993-03-11 | 1994-05-10 | Sterling Winthrop Inc. | Compositions of iodophenoxy alkylene ethers in film-forming materials for visualization of the gastrointestinal tract |
| US5472682A (en) * | 1993-03-31 | 1995-12-05 | Sterling Winthrop Inc. | Compositions of iodophenyl esters and iodophenyl sulfonates and pharmaceutically acceptable clays for visualization of the gastrointestinal tract |
| US5318769A (en) * | 1993-03-31 | 1994-06-07 | Sterling Winthrop Inc. | Compositions of iodophenyl esters for X-ray visualization of the gastrointestinal tract |
| US5336484A (en) * | 1993-03-31 | 1994-08-09 | Sterling Winthrop Inc. | Compositions of iodophenyl esters and iodophenyl sulfonates in film-forming materials for visualization of the gastronintestinal tract |
| US6051210A (en) | 1997-05-15 | 2000-04-18 | Bracco Research Usa | N,N-dimethyldiatrizoic acid and its conjugates as hepatobiliary agents for X-ray CT imaging |
-
1971
- 1971-06-23 CH CH914771A patent/CH545628A/xx not_active IP Right Cessation
-
1972
- 1972-03-16 DE DE2212741A patent/DE2212741C3/en not_active Expired
- 1972-03-29 AT AT270872A patent/AT315150B/en not_active IP Right Cessation
- 1972-03-29 AT AT270972A patent/AT313469B/en not_active IP Right Cessation
- 1972-04-17 RO RO7270578A patent/RO68261A/en unknown
- 1972-04-19 DD DD162404A patent/DD95912A5/xx unknown
- 1972-04-26 ES ES402140A patent/ES402140A1/en not_active Expired
- 1972-04-27 NL NL7205712.A patent/NL157798B/en unknown
- 1972-05-01 IL IL39329A patent/IL39329A/en unknown
- 1972-05-05 ZA ZA723058A patent/ZA723058B/en unknown
- 1972-05-12 CA CA141,950A patent/CA957371A/en not_active Expired
- 1972-05-17 CS CS7200003361A patent/CS182769B2/en unknown
- 1972-05-25 SE SE7206802A patent/SE391178B/en unknown
- 1972-05-29 JP JP47052580A patent/JPS529666B1/ja active Pending
- 1972-05-31 BG BG20617A patent/BG20336A3/xx unknown
- 1972-06-01 US US00258777A patent/US3825591A/en not_active Expired - Lifetime
- 1972-06-07 FI FI1618/72A patent/FI53660C/en active
- 1972-06-12 FR FR7221086A patent/FR2142986B1/fr not_active Expired
- 1972-06-19 BE BE785109A patent/BE785109R/en active
- 1972-06-20 PL PL1972156140A patent/PL90341B1/pl unknown
- 1972-06-20 BR BR4002/72A patent/BR7204002D0/en unknown
- 1972-06-21 AU AU43716/72A patent/AU461847B2/en not_active Expired
- 1972-06-21 DK DK309472AA patent/DK128108B/en unknown
- 1972-06-21 PH PH13646A patent/PH10571A/en unknown
- 1972-06-21 SU SU1801083A patent/SU451237A3/en active
- 1972-06-22 HU HUBA2764A patent/HU163382B/hu unknown
-
1979
- 1979-03-28 IT IT7921397A patent/IT7921397A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU461847B2 (en) | 1975-06-05 |
| JPS529666B1 (en) | 1977-03-17 |
| DD95912A5 (en) | 1973-02-20 |
| FR2142986A1 (en) | 1973-02-02 |
| FI53660C (en) | 1978-07-10 |
| DE2212741C3 (en) | 1974-06-12 |
| BG20336A3 (en) | 1975-11-05 |
| DE2212741A1 (en) | 1972-12-28 |
| HU163382B (en) | 1973-08-28 |
| FR2142986B1 (en) | 1976-04-16 |
| AT313469B (en) | 1974-02-25 |
| US3825591A (en) | 1974-07-23 |
| AT315150B (en) | 1974-05-10 |
| SU451237A3 (en) | 1974-11-25 |
| CA957371A (en) | 1974-11-05 |
| CS182769B2 (en) | 1978-05-31 |
| RO68261A (en) | 1981-11-04 |
| IL39329A (en) | 1975-04-25 |
| PL90341B1 (en) | 1977-01-31 |
| NL7205712A (en) | 1972-12-28 |
| BR7204002D0 (en) | 1973-11-01 |
| PH10571A (en) | 1977-06-30 |
| NL157798B (en) | 1978-09-15 |
| IL39329A0 (en) | 1972-07-26 |
| DK128108B (en) | 1974-03-04 |
| SE391178B (en) | 1977-02-07 |
| ZA723058B (en) | 1973-02-28 |
| AU4371672A (en) | 1974-01-03 |
| CH545628A (en) | 1974-02-15 |
| BE785109R (en) | 1972-12-19 |
| IT7921397A0 (en) | 1979-03-28 |
| FI53660B (en) | 1978-03-31 |
| DE2212741B2 (en) | 1973-11-08 |
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