ES388787A1 - Substituted quinoxaline-di oxides and process of preparation thereof - Google Patents

Substituted quinoxaline-di oxides and process of preparation thereof

Info

Publication number
ES388787A1
ES388787A1 ES388787A ES388787A ES388787A1 ES 388787 A1 ES388787 A1 ES 388787A1 ES 388787 A ES388787 A ES 388787A ES 388787 A ES388787 A ES 388787A ES 388787 A1 ES388787 A1 ES 388787A1
Authority
ES
Spain
Prior art keywords
formula
substituted
acyloxy
indicated above
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES388787A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES388787A1 publication Critical patent/ES388787A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/50—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to ring nitrogen atoms
    • C07D241/52—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A23K20/137—Heterocyclic compounds containing two hetero atoms, of which at least one is nitrogen
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/10—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Birds (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A procedure for preparing new quinoxaline-1,4-dioxides, substituted 2-heterocyclics, of the formula: **(See formula)** where X is a substituent at positions 6 or 7 and is hydrogen, chlorine, bromine, fluoro, methyl, methoxy or trifluoromethyl; Z'is hydroxy; acyloxy of formula -O2CR, where R is hydrogen or alcohol containing 1 to 3 carbon atoms; phenyl, or halogen (F, Cl, Br), phenyl substituted by lower alkoxy or dialkoxylamino or disubstituted amino of the formula NR3R5, where R3 and R5 are each alcohol containing 1 to 2 carbon atoms; A is an alcoholic radical of two to five carbon atoms or is part of a cycloalcohyl group containing from 3 to 8 atoms and where A as part of a cycloalcohyl group, is substituted by hydroxy; and the non-toxic acid addition salts of those compounds, where Z'is disubstituted amino; characterized by (a) reacting, in the presence of a base, a benzofuroxane of the formula: **(See formula)** where X is as indicated above, with a reagent selected from (ii) **(See formula)** where A is as indicated above and Z'is acyloxy, as indicated above, or disubstituted amino; and **(See formula)** where Z'is acyloxy of formula -O2CR where E is as indicated above, phenyl or c-amino-di-substituted phenyl; and when it is necessary to convert compounds of Formula IIA, where Z'is acyloxy, into those where Z' is hydroxy, by acid hydrolysis; and converting the compounds thus obtained in which Z'is di-substituted amino, into non-toxic acid addition salts, by reaction with suitable acids. (Machine-translation by Google Translate, not legally binding)
ES388787A 1970-03-18 1971-03-02 Substituted quinoxaline-di oxides and process of preparation thereof Expired ES388787A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2084270A 1970-03-18 1970-03-18
US2084170A 1970-03-18 1970-03-18

Publications (1)

Publication Number Publication Date
ES388787A1 true ES388787A1 (en) 1974-02-01

Family

ID=26693940

Family Applications (1)

Application Number Title Priority Date Filing Date
ES388787A Expired ES388787A1 (en) 1970-03-18 1971-03-02 Substituted quinoxaline-di oxides and process of preparation thereof

Country Status (13)

Country Link
JP (3) JPS5434756B1 (en)
AR (3) AR202999A1 (en)
AT (1) AT315865B (en)
BE (1) BE764088A (en)
CH (1) CH557356A (en)
DE (1) DE2111710C3 (en)
DK (1) DK131677C (en)
ES (1) ES388787A1 (en)
FR (1) FR2085717B1 (en)
GB (1) GB1330151A (en)
IT (1) IT1019008B (en)
NL (3) NL7102953A (en)
ZA (1) ZA711022B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3870718A (en) * 1971-12-13 1975-03-11 Pfizer 2-imidazolidine substituted quinoxaline-1,4-dioxides and intermediates therefor
CH575213A5 (en) * 1972-09-05 1976-05-14 Ciba Geigy Ag
US4012512A (en) * 1972-09-05 1977-03-15 Ciba-Geigy Corporation Animal feeds containing quinoxaline-di-n-oxide derivatives
US4254120A (en) * 1978-12-19 1981-03-03 Ciba-Geigy Corporation Growth promoting quinoxaline-di-N-oxide carboxamides
JPS6147989U (en) * 1984-09-04 1986-03-31 嶋田機器工業株式会社 Pressing device for the fabric to be sewn in a sewing machine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1058665B (en) * 1955-10-11 1959-06-04 Gen Aniline & Film Corp Drying accelerator for film formers containing drying or semi-drying oils
DE1670935C3 (en) * 1967-10-04 1975-12-04 Bayer Ag, 5090 Leverkusen 2-Methyl-3-carboxamidoquinoxaline-1,4-dl-N-oxides, a process for their preparation and antibacterial agents containing these compounds

Also Published As

Publication number Publication date
DK131677B (en) 1975-08-18
GB1330151A (en) 1973-09-12
ZA711022B (en) 1971-12-29
BE764088A (en) 1971-09-13
JPS53127486A (en) 1978-11-07
NL7102953A (en) 1971-09-21
AR197977A1 (en) 1974-05-24
CH557356A (en) 1974-12-31
DE2111710A1 (en) 1971-09-30
FR2085717B1 (en) 1975-06-06
DE2111710B2 (en) 1979-01-25
AR204703A1 (en) 1976-02-27
JPS554748B2 (en) 1980-01-31
IT1019008B (en) 1977-11-10
JPS5434756B1 (en) 1979-10-29
JPS554749B2 (en) 1980-01-31
DE2111710C3 (en) 1979-09-13
NL7808008A (en) 1978-11-30
AT315865B (en) 1974-06-10
FR2085717A1 (en) 1971-12-31
DK131677C (en) 1976-04-26
JPS53127487A (en) 1978-11-07
NL7808009A (en) 1978-11-30
AR202999A1 (en) 1975-08-08

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