ES400141A1 - Procedure for the obtaining of 3-nitroimidazo 1,2-b piridazines (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for obtaining 3-nitro-imidazo [1, -2-b] pyradazines of general formula ** formula ** where R1 is H or C1-C4 lower alkyl, and W is (lower alkyl) -oxy-alkythio lower,, phenylalkoxy, lower alkyl aminoalkyloxy, hydroxy lower alkoxy, lower alkyloxy, lower alkenyloxy, amino monoalkyl lower amino, di (lower alkyl) amino, hydroxy lower alkyl (amino), (alkoxy lower alkyl), amino, phenyl lower alkyl amino, pyridyl lower alkyl amino, (C3 to C6) cycloalkyl amino, pyrrolidinyl, piperidinyl, morpholino, N4-lower alkyl pipera-zinyl, (N4-aryl or substituted aryl) piperazinyl, N4-lower carboalkoxy piperazinyl, imidazolyl, lower alkylcarbomamido, and carbon lower alkyl (lower alkyl) amido, characterized by (a) reacting a compound of the formula ** formula ** wherein R1 is as defined above, V is a halogen atom and X is H or NO2 with a compound of the formula MZA III in d ondeM is a metal; z is oxygen or sulfur, and A is lower alkyl, lower alkoxy lower alkyl, phenyl lower alkyl, hydroxy lower alkyl, lower alkylamino, lower alkenyl, or (b) reacting a compound of formula II with a compound of formula R2R3NH, IV where R2 and R3 are H, lower alkyl, hydroxy lower alkyl, lower alkoxy lower alkyl, phenyl lower alkyl, pyridyl lower alkyl, cycloalkyl, tetramethylene, pentamethylene, 3-oxapentamethylene, 3- (lower alkylase) pentamethylene, 3-arylaza) or 3- (substituted arylaza) pentamethylene, 3- (lower carbo alkoxyaza) pentamethylene, lower alkyl carbonamido and when © X in formula II is H convert H to NO2 either before or after the introduction of W in formula I, by reacting said compound with a reagent capable of introducing a nitro group at position 3, and (d) if desired, preparing the pharmaceutically acceptable acid addition salts thereof. (Machine-translation by Google Translate, not legally binding)