ES408263A2 - Procedure for the obtaining of 3-nitroimidan (1,2-b) pyridazines. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Improvements introduced in the object of the main patent No. 400,141 filed on February 24, 1972, by: PROCEDURE FOR THE OBTAINING OF 3-NITROINIZED [1, 2-b] PIRIDAZINES of formula: **(See formula)** where R1 is H or C1-C4 lower alkyl, and W is (lower alkyl) oxy, lower alkylthio, lower phenylalkoxy, lower alkylaminoalkoxy, dialkylaminoalkoxy, lower hydroxyalkoxy, lower alkoxy lower alkyloxy, lower alkenyloxy, amino monoalkyl lower amino, di (lower alkyl) amino, (hydroxyalkyl lower) amino, (alkoxy lower alkyl) amino, phenyl lower alkyl amino, pyridyl lower alkyl amino, cycloalkyl (C3 to C6) amino, pyrrolidinyl, piperidinyl, morpholinyl, N4-lower alkyl piperazinyl, (N4-aryl or substituted aryl) piperazinyl, N4-carboalkoxy lower piperazinyl, midazolyl, lower alkyl carbonamido, and lower alkyl carbon (lower alkyl) amido, characterized in that they comprise reacting a compound of formula: **(See formula)** where R1 is as previously defined; V is lower alkylsulfonyl, arylsulfonyl, lower alkylsulfoxy, arylsulfoxy, tri (lower alkyl) amino, lower alkylthio, nitro or trihalomethyl chloride; and X is H or N2O with a compound of the formula: M-Z-A (III) where M is an alkali metal, Z is oxygen or sulfur, and A is lower alkyl, lower alkoxy lower alkyl, phenylalkyl, hydroxy lower alkyl, lower alkylamino, or lower alkenyl; and when X of formula II is H convert H to H2O either before or after the introduction of W in formula I, by reaction of said compound with a reagent capable of introducing a nitro group at position 3, and if You want to prepare the pharmaceutically acceptable acid addition salts thereof. (Machine-translation by Google Translate, not legally binding)