ES396451A1 - PROCEDURE FOR THE PREPARATION OF AZEPINE DERIVATIVES. - Google Patents
PROCEDURE FOR THE PREPARATION OF AZEPINE DERIVATIVES.Info
- Publication number
- ES396451A1 ES396451A1 ES396451A ES396451A ES396451A1 ES 396451 A1 ES396451 A1 ES 396451A1 ES 396451 A ES396451 A ES 396451A ES 396451 A ES396451 A ES 396451A ES 396451 A1 ES396451 A1 ES 396451A1
- Authority
- ES
- Spain
- Prior art keywords
- benzyl
- thiourea
- halogen
- alkyl
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001538 azepines Chemical class 0.000 title 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 8
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 2
- 239000004202 carbamide Substances 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- GMHPWGYTSXHHPI-UHFFFAOYSA-N azepan-4-one Chemical compound O=C1CCCNCC1 GMHPWGYTSXHHPI-UHFFFAOYSA-N 0.000 abstract 1
- 150000002118 epoxides Chemical class 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- -1 hexahydrobenzyl Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
Cpds (I) and their salts. (where R1 is H, 1-4C alkyl opt. substd. by OH, allyl, cycloalkyl, hexahydrobenzyl, phenyl, phenethyl or benzyl opt. substd by 1 or 2 halogen, 1-3-MeO, Cf3 or 1-3C alkyl, R2 is (when X is S) H, 1-5C alkyl, allyl, cycloalkyl, phenyl, benzyl, or phenethyl, and (when X is O) H) are prepd by reacting a hexahydroazepin-4-one with a urea or thiourea in the presence of halogen or a halo hydroazepin-4-one with a urea or thiourea or a 4-alkoxy-tetrahydroazepine with a thiourea in the presence of a halogen or by reducing (I R1 or R2= acyl) by hydroxyalkylating (I R1=He with an epoxide or by diacylating a 6-acylamino deriv. of (I). Thus 1-benzyl-5-bromohexahydro-1H-azepinone-(4)-and thiourea gave (I R1=benzyl R2=N, X=S).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2040510A DE2040510C3 (en) | 1970-08-14 | 1970-08-14 | Oxazole and thiazole square brackets on 5,4-d] azepine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES396451A1 true ES396451A1 (en) | 1974-05-16 |
Family
ID=5779804
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES396452A Expired ES396452A1 (en) | 1970-08-14 | 1971-10-28 | 2-amino-4,5,7,8-tetrahydro-6h-thiazolo-or oxazolo(5,4-d) - azepines - as hypotensive, antiphlogistic, sedative and bechic agents |
| ES396451A Expired ES396451A1 (en) | 1970-08-14 | 1971-10-28 | PROCEDURE FOR THE PREPARATION OF AZEPINE DERIVATIVES. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES396452A Expired ES396452A1 (en) | 1970-08-14 | 1971-10-28 | 2-amino-4,5,7,8-tetrahydro-6h-thiazolo-or oxazolo(5,4-d) - azepines - as hypotensive, antiphlogistic, sedative and bechic agents |
Country Status (8)
| Country | Link |
|---|---|
| AT (5) | AT310180B (en) |
| CH (4) | CH562830A5 (en) |
| DE (1) | DE2040510C3 (en) |
| ES (2) | ES396452A1 (en) |
| PL (5) | PL92460B1 (en) |
| RO (1) | RO59322A (en) |
| SU (5) | SU461507A3 (en) |
| ZA (1) | ZA715393B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE795257A (en) * | 1972-02-10 | 1973-08-09 | Thomae Gmbh Dr K | NEW OXAZOLS |
| GB2173187B (en) * | 1985-03-23 | 1988-05-18 | Erba Farmitalia | Condensed 2-substituted thiazole derivatives |
| US4826686A (en) * | 1985-12-14 | 1989-05-02 | Boehringer Ingelheim Kg | Therapeutic system |
| DE3610388A1 (en) * | 1986-03-27 | 1987-10-01 | Bernhard Dr Wessling | STABLE ELECTRODES BASED ON MACROMOLECULAR MATERIALS AND METHOD FOR THEIR USE |
| US7091181B2 (en) | 1994-12-12 | 2006-08-15 | Omeros Corporation | Method of inhibition of pain and inflammation during surgery comprising administration of soluble TNF receptors |
| US7973068B2 (en) | 1998-10-20 | 2011-07-05 | Omeros Corporation | Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation |
| US20030087962A1 (en) | 1998-10-20 | 2003-05-08 | Omeros Corporation | Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation |
| AU1319200A (en) * | 1998-10-20 | 2000-05-08 | Omeros Medical Systems, Inc. | Irrigation solution and method for inhibition of pain and inflammation |
| EP2935284A4 (en) * | 2012-12-21 | 2016-04-27 | Abbvie Inc | Heterocyclic nuclear hormone receptor modulators |
-
1970
- 1970-08-14 DE DE2040510A patent/DE2040510C3/en not_active Expired
-
1971
- 1971-08-04 RO RO70459A patent/RO59322A/ro unknown
- 1971-08-05 SU SU1896325A patent/SU461507A3/en active
- 1971-08-05 SU SU1896328A patent/SU474151A3/en active
- 1971-08-05 SU SU1691527A patent/SU442601A3/en active
- 1971-08-05 SU SU1896327A patent/SU461508A3/en active
- 1971-08-11 CH CH160275A patent/CH562830A5/xx not_active IP Right Cessation
- 1971-08-11 CH CH160075A patent/CH562829A5/xx not_active IP Right Cessation
- 1971-08-11 CH CH159975A patent/CH561730A5/xx not_active IP Right Cessation
- 1971-08-11 CH CH160175A patent/CH571009A5/xx not_active IP Right Cessation
- 1971-08-12 ZA ZA715393A patent/ZA715393B/en unknown
- 1971-08-13 AT AT899172A patent/AT310180B/en active
- 1971-08-13 AT AT899072A patent/AT310179B/en active
- 1971-08-13 PL PL1971181164A patent/PL92460B1/pl unknown
- 1971-08-13 PL PL1971181167A patent/PL92463B1/pl unknown
- 1971-08-13 PL PL1971181166A patent/PL92462B1/pl unknown
- 1971-08-13 AT AT899372A patent/AT310764B/en not_active IP Right Cessation
- 1971-08-13 AT AT899472A patent/AT310182B/en active
- 1971-08-13 AT AT899272A patent/AT310181B/en active
- 1971-08-13 PL PL1971181165A patent/PL92461B1/pl unknown
- 1971-08-13 PL PL1971181163A patent/PL92458B1/pl unknown
- 1971-10-28 ES ES396452A patent/ES396452A1/en not_active Expired
- 1971-10-28 ES ES396451A patent/ES396451A1/en not_active Expired
-
1973
- 1973-03-20 SU SU1896326A patent/SU503526A3/en active
Also Published As
| Publication number | Publication date |
|---|---|
| SU474151A3 (en) | 1975-06-14 |
| CH561730A5 (en) | 1975-05-15 |
| AT310180B (en) | 1973-09-25 |
| DE2040510B2 (en) | 1979-07-05 |
| RO59322A (en) | 1976-02-15 |
| PL92460B1 (en) | 1977-04-30 |
| SU503526A3 (en) | 1976-02-15 |
| AT310181B (en) | 1973-09-25 |
| SU461507A3 (en) | 1975-02-25 |
| CH571009A5 (en) | 1975-12-31 |
| CH562830A5 (en) | 1975-06-13 |
| AT310182B (en) | 1973-09-25 |
| DE2040510A1 (en) | 1972-02-17 |
| ZA715393B (en) | 1972-05-31 |
| ES396452A1 (en) | 1974-05-16 |
| PL92462B1 (en) | 1977-04-30 |
| AT310179B (en) | 1973-09-25 |
| CH562829A5 (en) | 1975-06-13 |
| SU442601A3 (en) | 1974-09-05 |
| SU461508A3 (en) | 1975-02-25 |
| PL92461B1 (en) | 1977-04-30 |
| AT310764B (en) | 1973-10-10 |
| PL92463B1 (en) | 1977-04-30 |
| DE2040510C3 (en) | 1980-03-06 |
| PL92458B1 (en) | 1977-04-30 |
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