ES392570A1 - 3,-4,-dideoxykanamycin b active against resistant bacteria and its synthesis - Google Patents

3,-4,-dideoxykanamycin b active against resistant bacteria and its synthesis

Info

Publication number
ES392570A1
ES392570A1 ES392570A ES392570A ES392570A1 ES 392570 A1 ES392570 A1 ES 392570A1 ES 392570 A ES392570 A ES 392570A ES 392570 A ES392570 A ES 392570A ES 392570 A1 ES392570 A1 ES 392570A1
Authority
ES
Spain
Prior art keywords
synthesis
kanamycin
dideoxykanamycin
groups
active against
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES392570A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP45065760A external-priority patent/JPS507595B1/ja
Priority claimed from JP3087171A external-priority patent/JPS5146110B1/ja
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Publication of ES392570A1 publication Critical patent/ES392570A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Manufacture And Refinement Of Metals (AREA)

Abstract

Process for the synthesis of 3', 4'-dideoxy-kanamycin B starting from kanamycin B, which includes the protection of amino groups and of all or part of hydroxyl groups apart from 3' and 4'-hydroxyl groups of kanamycin B by a conventional method, sulfonylating the 3'and 4'-hydroxyl groups to provide a derivative having disulfonic ester groups, removing the 3', 4'-disulfonic esters by the usual method to give 3'compounds, 4'- unsaturated, reducing compound 3', 4'- unsaturated and removing residual protecting groups. (Machine-translation by Google Translate, not legally binding)
ES392570A 1970-07-29 1971-06-23 3,-4,-dideoxykanamycin b active against resistant bacteria and its synthesis Expired ES392570A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP45065760A JPS507595B1 (en) 1970-07-29 1970-07-29
JP3087171A JPS5146110B1 (en) 1971-05-11 1971-05-11

Publications (1)

Publication Number Publication Date
ES392570A1 true ES392570A1 (en) 1974-06-16

Family

ID=26369303

Family Applications (1)

Application Number Title Priority Date Filing Date
ES392570A Expired ES392570A1 (en) 1970-07-29 1971-06-23 3,-4,-dideoxykanamycin b active against resistant bacteria and its synthesis

Country Status (23)

Country Link
AT (1) AT320846B (en)
BE (1) BE770692A (en)
BG (1) BG19188A3 (en)
CA (1) CA953294A (en)
CH (1) CH552586A (en)
DK (1) DK127778B (en)
ES (1) ES392570A1 (en)
FI (1) FI57596C (en)
FR (1) FR2103935A5 (en)
GB (1) GB1349302A (en)
HK (1) HK57477A (en)
HU (1) HU162704B (en)
IE (1) IE35480B1 (en)
IL (1) IL36973A (en)
LU (1) LU63625A1 (en)
MY (1) MY7800147A (en)
NL (1) NL163219C (en)
NO (1) NO134117C (en)
PL (1) PL83206B1 (en)
RO (1) RO63815A (en)
SE (1) SE398753B (en)
SU (1) SU511007A3 (en)
YU (1) YU35895B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1537905A (en) * 1975-12-09 1979-01-10 Microbial Chem Res Found Processes for the preparation of 3',4'-dideoxykanamycin b
JPS6029720B2 (en) * 1975-12-11 1985-07-12 財団法人微生物化学研究会 Novel production method of 3',4'-dideoxykanamycin B
JPS52153942A (en) * 1976-06-16 1977-12-21 Microbial Chem Res Found Preparation of kanamicin c deoxy derivatives and kanamicine c or its deoxy derivatives
JPS6052719B2 (en) * 1976-12-16 1985-11-20 財団法人微生物化学研究会 Novel production method for 3',4'-dideoxykanamycin B
AU2007255856B2 (en) * 2006-06-02 2012-08-16 Meiji Seika Pharma Co., Ltd. Novel aminoglycoside antibiotic

Also Published As

Publication number Publication date
IL36973A (en) 1974-06-30
DE2135191B2 (en) 1976-09-02
NL7109001A (en) 1972-02-01
NL163219C (en) 1980-08-15
NO134117C (en) 1976-08-18
YU35895B (en) 1981-08-31
FI57596C (en) 1980-09-10
DE2135191A1 (en) 1972-02-03
YU196371A (en) 1981-02-28
PL83206B1 (en) 1975-12-31
MY7800147A (en) 1978-12-31
CH552586A (en) 1974-08-15
RO63815A (en) 1979-01-15
NO134117B (en) 1976-05-10
FI57596B (en) 1980-05-30
IE35480B1 (en) 1976-03-03
SE398753B (en) 1978-01-16
LU63625A1 (en) 1971-11-26
FR2103935A5 (en) 1972-04-14
IE35480L (en) 1972-01-29
HU162704B (en) 1973-03-28
DK127778B (en) 1974-01-07
GB1349302A (en) 1974-04-03
HK57477A (en) 1977-11-25
CA953294A (en) 1974-08-20
BG19188A3 (en) 1975-04-30
NL163219B (en) 1980-03-17
AT320846B (en) 1975-02-25
BE770692A (en) 1971-12-01
SU511007A3 (en) 1976-04-15

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