ES391532A1 - Procedure for the obtaining of penicillines. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the obtaining of penicillines. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES391532A1 ES391532A1 ES391532A ES391532A ES391532A1 ES 391532 A1 ES391532 A1 ES 391532A1 ES 391532 A ES391532 A ES 391532A ES 391532 A ES391532 A ES 391532A ES 391532 A1 ES391532 A1 ES 391532A1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- formula
- see formula
- general
- general formulas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
- C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
- C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
- C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
- C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
- C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
- C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
- C07D499/68—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms with aromatic rings as additional substituents on the carbon chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Procedure for obtaining penicillins, of general formula I: **(See formula)** whose compounds, as for the center of chirality Cx; they can be presented in the two possible configurations R and S and as mixtures of the resulting diastereomers, as well as the pharmaceutically tolerable non-toxic salts of these compounds; characterized in that a compound chosen from the compounds of general formula II **(See formula)** condensation products of compounds of general formula II with carbonyl compounds, such as acetone, of general formula III **(See formula)** and compounds of general formulas IV and V **(See formula)** (see formula) they are reacted with a compound chosen from the compounds of general formulas VI, VII and VIII **(See formula)** in which W represents halogen or asido, in the case of using the compounds of the general formulas II and III, in anhydrous or aqueous solvents, in the presence of a base and, in the case of using the compounds of the general formulas IV and V, in anhydrous and hydroxyl group-free solvents, with or without addition of a base, at a temperature between -20º and + 50ºC. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2025414A DE2025414C3 (en) | 1970-05-25 | 1970-05-25 | Cyclic acylureidophenylacetamidopenicillanic acids |
| DE19712104580 DE2104580C3 (en) | 1971-02-01 | 1971-02-01 | Acylureidopenicillins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES391532A1 true ES391532A1 (en) | 1974-10-01 |
Family
ID=25759178
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES391532A Expired ES391532A1 (en) | 1970-05-25 | 1971-05-25 | Procedure for the obtaining of penicillines. (Machine-translation by Google Translate, not legally binding) |
| ES403125A Expired ES403125A1 (en) | 1970-05-25 | 1972-05-24 | Procedure for obtaining an antibacterial composition. (Machine-translation by Google Translate, not legally binding) |
| ES403124A Expired ES403124A1 (en) | 1970-05-25 | 1972-05-24 | Procedure for obtaining an antibacterial composition. (Machine-translation by Google Translate, not legally binding) |
| ES403126A Expired ES403126A1 (en) | 1970-05-25 | 1972-05-24 | Procedure for obtaining an antibacterial composition. (Machine-translation by Google Translate, not legally binding) |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES403125A Expired ES403125A1 (en) | 1970-05-25 | 1972-05-24 | Procedure for obtaining an antibacterial composition. (Machine-translation by Google Translate, not legally binding) |
| ES403124A Expired ES403124A1 (en) | 1970-05-25 | 1972-05-24 | Procedure for obtaining an antibacterial composition. (Machine-translation by Google Translate, not legally binding) |
| ES403126A Expired ES403126A1 (en) | 1970-05-25 | 1972-05-24 | Procedure for obtaining an antibacterial composition. (Machine-translation by Google Translate, not legally binding) |
Country Status (28)
| Country | Link |
|---|---|
| JP (1) | JPS5538357B1 (en) |
| AR (2) | AR195267A1 (en) |
| AT (1) | AT307617B (en) |
| BE (1) | BE767647A (en) |
| BG (1) | BG23220A3 (en) |
| CA (1) | CA943128A (en) |
| CH (1) | CH562249A5 (en) |
| CS (1) | CS171230B2 (en) |
| CY (1) | CY829A (en) |
| DD (1) | DD91497B3 (en) |
| DK (1) | DK133679C (en) |
| EG (1) | EG10856A (en) |
| ES (4) | ES391532A1 (en) |
| FI (1) | FI54484C (en) |
| FR (1) | FR2100681B1 (en) |
| GB (1) | GB1301961A (en) |
| HU (1) | HU162205B (en) |
| IE (1) | IE35311B1 (en) |
| IL (1) | IL36905A (en) |
| KE (1) | KE2592A (en) |
| LU (1) | LU63203A1 (en) |
| NL (1) | NL172660C (en) |
| NO (1) | NO141164C (en) |
| PH (1) | PH14794A (en) |
| RO (2) | RO62689A (en) |
| SE (1) | SE395896B (en) |
| SU (1) | SU472507A3 (en) |
| YU (1) | YU130271A (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2354219A1 (en) * | 1973-10-30 | 1975-05-07 | Bayer Ag | BETA-LACTAM-ANTIBIOTICA, A PROCESS FOR THEIR MANUFACTURING AND ITS USE AS A MEDICINAL PRODUCT |
| US4039673A (en) | 1973-10-30 | 1977-08-02 | Bayer Aktiengesellschaft | Penicillins and cephalosporins and their production |
| GB1486349A (en) * | 1974-11-28 | 1977-09-21 | Bayer Ag | Beta-lactam antibiotics process for their preparation and their use as medicaments |
| GB1584400A (en) * | 1976-12-24 | 1981-02-11 | Bayer Ag | (2-oxo-imidazoliden-1-yl(carbonylamino)-acetamido-cephalosporins and penicillins |
| DE2658906A1 (en) * | 1976-12-24 | 1978-07-06 | Bayer Ag | BETA-LACTAM ANTIBIOTICS, THE METHOD OF MANUFACTURING AND THEIR USE AS A MEDICINAL PRODUCT |
| CA1133896A (en) * | 1978-05-26 | 1982-10-19 | Nobuhiro Oi | Penicillanic acid derivative and process for preparing the same |
| JPS5732289A (en) | 1980-08-05 | 1982-02-20 | Chugai Pharmaceut Co Ltd | Alpha-substituted ureidobenzylpenicillin |
-
1971
- 1971-04-23 CH CH599071A patent/CH562249A5/xx not_active IP Right Cessation
- 1971-05-13 BG BG17580A patent/BG23220A3/xx unknown
- 1971-05-19 EG EG209/71A patent/EG10856A/en active
- 1971-05-19 CS CS3646A patent/CS171230B2/cs unknown
- 1971-05-20 SU SU1661304A patent/SU472507A3/en active
- 1971-05-21 IE IE643/71A patent/IE35311B1/en unknown
- 1971-05-21 LU LU63203D patent/LU63203A1/xx unknown
- 1971-05-21 FI FI1401/71A patent/FI54484C/en active
- 1971-05-24 SE SE7106667A patent/SE395896B/en unknown
- 1971-05-24 IL IL7136905A patent/IL36905A/en unknown
- 1971-05-24 PH PH12493A patent/PH14794A/en unknown
- 1971-05-24 YU YU01302/71A patent/YU130271A/en unknown
- 1971-05-24 NO NO1945/71A patent/NO141164C/en unknown
- 1971-05-24 DD DD71155301A patent/DD91497B3/en unknown
- 1971-05-24 AR AR235756A patent/AR195267A1/en active
- 1971-05-24 DK DK251071A patent/DK133679C/en active
- 1971-05-25 FR FR7118932A patent/FR2100681B1/fr not_active Expired
- 1971-05-25 ES ES391532A patent/ES391532A1/en not_active Expired
- 1971-05-25 RO RO7100078134A patent/RO62689A/en unknown
- 1971-05-25 CA CA113,784A patent/CA943128A/en not_active Expired
- 1971-05-25 RO RO67014A patent/RO59157A/ro unknown
- 1971-05-25 AT AT450471A patent/AT307617B/en not_active IP Right Cessation
- 1971-05-25 CY CY829A patent/CY829A/en unknown
- 1971-05-25 HU HUBA2591A patent/HU162205B/hu unknown
- 1971-05-25 JP JP3524471A patent/JPS5538357B1/ja active Pending
- 1971-05-25 GB GB1688071A patent/GB1301961A/en not_active Expired
- 1971-05-25 NL NLAANVRAGE7107175,A patent/NL172660C/en not_active IP Right Cessation
- 1971-05-25 BE BE767647A patent/BE767647A/xx not_active IP Right Cessation
-
1972
- 1972-05-24 ES ES403125A patent/ES403125A1/en not_active Expired
- 1972-05-24 ES ES403124A patent/ES403124A1/en not_active Expired
- 1972-05-24 ES ES403126A patent/ES403126A1/en not_active Expired
-
1973
- 1973-09-14 AR AR250097A patent/AR195946A1/en active
-
1975
- 1975-12-22 KE KE2592*UA patent/KE2592A/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19910215 |