ES327313A1 - A procedure for the obtaining of 3,4-dihydroxy-phenyl alcanolamines. (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure for the obtaining of 3,4-dihydroxy-phenyl alcanolamines. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES327313A1
ES327313A1 ES0327313A ES327313A ES327313A1 ES 327313 A1 ES327313 A1 ES 327313A1 ES 0327313 A ES0327313 A ES 0327313A ES 327313 A ES327313 A ES 327313A ES 327313 A1 ES327313 A1 ES 327313A1
Authority
ES
Spain
Prior art keywords
general formula
formula
indicated above
meaning indicated
optionally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0327313A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Publication of ES327313A1 publication Critical patent/ES327313A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Process for obtaining new 3,4-dihydroxy-phenyl-alkanolamines of the general formula ** (See formula) ** in which R1 means the methyl or methoxy group, and R2 hydrogen, the methyl or ethyl group, their stereoisomers and optically active isomers, as well as the addition salts with physiologically tolerable acids, characterized a) why ketones of the general formula in which R 'represents a protective group for the hydroxyl radical, which can be easily separated, R "hydrogen or the benzyl radical and R1 and R2 are defined as previously indicated, are catalytically reduced, b) because they are reduced in the presence of isopropylamine dikecompounds of the general formula ** (See formula) ** in which R ', R1 and R2 have the meaning indicated above; c) why epoxides of the general formula are reacted ** (See formula) ** in which R ', R1 and R2 have the meaning indicated above, with compounds of the formula (CH3) 2 in which R "has the meaning indicated above; d) why the amines of the general formula ** (See formula) ** in which R ', R1 and R2 have the meaning indicated above, are reductively alkylated with acetone, the substituents R' optionally being separated in known manner; and that, optionally, the compounds obtained by processes (a) to (d) are separated in the manner known per se from the optically active stereoisomers and antipodes and, optionally, the addition salts with physiologically tolerable acids are obtained. (Machine-translation by Google Translate, not legally binding)
ES0327313A 1965-06-01 1966-05-28 A procedure for the obtaining of 3,4-dihydroxy-phenyl alcanolamines. (Machine-translation by Google Translate, not legally binding) Expired ES327313A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEB0082208 1965-06-01

Publications (1)

Publication Number Publication Date
ES327313A1 true ES327313A1 (en) 1967-08-16

Family

ID=6981422

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0327313A Expired ES327313A1 (en) 1965-06-01 1966-05-28 A procedure for the obtaining of 3,4-dihydroxy-phenyl alcanolamines. (Machine-translation by Google Translate, not legally binding)

Country Status (8)

Country Link
BE (1) BE681864A (en)
CH (1) CH471072A (en)
DE (1) DE1493482A1 (en)
DK (1) DK118613B (en)
ES (1) ES327313A1 (en)
FR (1) FR5706M (en)
GB (1) GB1136549A (en)
NL (1) NL6607489A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3969410A (en) * 1972-01-12 1976-07-13 Boehringer Ingelheim Gmbh 1-(2'-Alkyl-3',4'-dihydroxy-phenyl)-2-(phenylalkyl-amino)-alkanols-(1) and salts thereof
US4042713A (en) * 1966-10-18 1977-08-16 Boehringer Ingelheim Gmbh Pharmaceutical compositions containing a 1-(2-alkyl-3,4-dihydroxy-phenyl)-2-(phenylalkyl-amino)-alkanol-(1) and method of use
EP0103830A3 (en) * 1982-09-22 1985-07-31 Bayer Ag Phenylethylemine derivatires as growth stimulators
FR2724654B1 (en) * 1994-09-16 1997-12-12 Roussel Uclaf NEW GALLIC ACID DERIVATIVES, THEIR PREPARATION PROCESS, THE NEW INTERMEDIATES OBTAINED, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
BE681864A (en) 1966-11-30
DE1493482A1 (en) 1969-01-16
GB1136549A (en) 1968-12-11
NL6607489A (en) 1966-12-02
FR5706M (en) 1968-01-15
DK118613B (en) 1970-09-14
CH471072A (en) 1969-04-15

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