ES392229A1 - Benzophenone complexes and their conversion to 1,4-benzodiazepine s - Google Patents

Benzophenone complexes and their conversion to 1,4-benzodiazepine s

Info

Publication number
ES392229A1
ES392229A1 ES392229A ES392229A ES392229A1 ES 392229 A1 ES392229 A1 ES 392229A1 ES 392229 A ES392229 A ES 392229A ES 392229 A ES392229 A ES 392229A ES 392229 A1 ES392229 A1 ES 392229A1
Authority
ES
Spain
Prior art keywords
group
hexamethylenetetramine
benzodiazepine
benzophenone
complexes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES392229A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CRC Compagnie di Ricerca Chimica SpA
Original Assignee
CRC Compagnie di Ricerca Chimica SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CRC Compagnie di Ricerca Chimica SpA filed Critical CRC Compagnie di Ricerca Chimica SpA
Publication of ES392229A1 publication Critical patent/ES392229A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals

Abstract

A procedure for obtaining 1,4 benzodiazepines of general formula **(See formula)** wherein R means a cyclopropyl group or an alcohol or hydrogen group, and R1, hydrogen, halogen, a nitro group or a fluoromethyl group, characterized in that a compound of the general formula **(See formula)** wherein Y represents a halogen atom or a group -Y ⊖ N4 (CH2) ⊕ 6, is cyclized with ammonia or hexamethylenetetramine under ring closure and, in case Y represents a halogen atom, ring closure is then carried out with ammonia or hexamethylenetetramine, while in the In the second case, the complex compound is first produced with hexamethylenetetramine, which is cyclized later intramolecularly. (Machine-translation by Google Translate, not legally binding)
ES392229A 1970-06-16 1971-06-14 Benzophenone complexes and their conversion to 1,4-benzodiazepine s Expired ES392229A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH912470A CH549030A (en) 1970-06-16 1970-06-16 PROCESS FOR THE PREPARATION OF 1,2-DIHYDRO-3H-1,4-BENZODIAZEPINES.

Publications (1)

Publication Number Publication Date
ES392229A1 true ES392229A1 (en) 1973-11-16

Family

ID=4348591

Family Applications (1)

Application Number Title Priority Date Filing Date
ES392229A Expired ES392229A1 (en) 1970-06-16 1971-06-14 Benzophenone complexes and their conversion to 1,4-benzodiazepine s

Country Status (14)

Country Link
JP (1) JPS5218198B1 (en)
AT (1) AT310759B (en)
CA (1) CA946386A (en)
CH (1) CH549030A (en)
DE (1) DE2129683A1 (en)
ES (1) ES392229A1 (en)
FI (1) FI53454C (en)
FR (1) FR2099752A5 (en)
GB (1) GB1317339A (en)
NL (1) NL155544B (en)
NO (1) NO131597B (en)
SE (1) SE414306B (en)
YU (1) YU36167B (en)
ZA (1) ZA713923B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4155904A (en) * 1973-02-08 1979-05-22 Schering Corporation Process for the preparation of 1,4-benzo-diazepines and 1,4-benzodiazepinones
JPS55113083U (en) * 1979-02-02 1980-08-08

Also Published As

Publication number Publication date
CA946386A (en) 1974-04-30
SE414306B (en) 1980-07-21
YU36167B (en) 1982-02-25
FR2099752A5 (en) 1972-03-17
AT310759B (en) 1973-10-10
NL155544B (en) 1978-01-16
GB1317339A (en) 1973-05-16
NL7108245A (en) 1971-12-20
JPS5218198B1 (en) 1977-05-20
FI53454B (en) 1978-01-31
FI53454C (en) 1978-05-10
YU154771A (en) 1981-06-30
ZA713923B (en) 1972-01-26
NO131597B (en) 1975-03-17
CH549030A (en) 1974-05-15
DE2129683A1 (en) 1972-01-13

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