ES393999A1 - Procedure for the preparation of 5-phenyl-3h-1,4 substitute benzodiazepin. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of 5-phenyl-3h-1,4 substitute benzodiazepin. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES393999A1
ES393999A1 ES393999A ES393999A ES393999A1 ES 393999 A1 ES393999 A1 ES 393999A1 ES 393999 A ES393999 A ES 393999A ES 393999 A ES393999 A ES 393999A ES 393999 A1 ES393999 A1 ES 393999A1
Authority
ES
Spain
Prior art keywords
formula
translation
phenyl
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES393999A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmedical SA Lab
Original Assignee
Pharmedical SA Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmedical SA Lab filed Critical Pharmedical SA Lab
Publication of ES393999A1 publication Critical patent/ES393999A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Procedure for the preparation of substituted 5-phenyl-3H-1,4-henzodiazepine of formula (1): **(See formula)** where: R1 is selected from hydrogen, lower alkyl, alkylaryl and aryl. R2, R3 are selected from hydrogen, halogen, lower alkyl, alkylaryl, al-coxyl, nitro, sulfonic and sulfamido. Y is selected from carbonyl and methylene, characterized in that a compound of formula (2) is reacted: **(See formula)** where: X is halogen and the substituents R2 and R3 have the meanings given above, with a compound of the formula: R1 N H - Y-CH2 - N Z (3) where Z is a primary amine function blocking agent and R1 and Y have the same meaning given above, being treated with hydrazine hydrate, to regenerate the primary amine, which reacts with the carbonyl group to form a benzodiazepine ring. (Machine-translation by Google Translate, not legally binding)
ES393999A 1971-03-19 1971-08-07 Procedure for the preparation of 5-phenyl-3h-1,4 substitute benzodiazepin. (Machine-translation by Google Translate, not legally binding) Expired ES393999A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AR23457971 1971-03-19

Publications (1)

Publication Number Publication Date
ES393999A1 true ES393999A1 (en) 1974-06-01

Family

ID=3461927

Family Applications (1)

Application Number Title Priority Date Filing Date
ES393999A Expired ES393999A1 (en) 1971-03-19 1971-08-07 Procedure for the preparation of 5-phenyl-3h-1,4 substitute benzodiazepin. (Machine-translation by Google Translate, not legally binding)

Country Status (4)

Country Link
BE (1) BE772935A (en)
CH (1) CH580088A5 (en)
DE (1) DE2159919A1 (en)
ES (1) ES393999A1 (en)

Also Published As

Publication number Publication date
BE772935A (en) 1972-01-17
DE2159919A1 (en) 1972-09-28
CH580088A5 (en) 1976-09-30

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