ES404627A1 - Process for the manufacture of benzodiazepine derivatives - Google Patents

Process for the manufacture of benzodiazepine derivatives

Info

Publication number
ES404627A1
ES404627A1 ES404627A ES404627A ES404627A1 ES 404627 A1 ES404627 A1 ES 404627A1 ES 404627 A ES404627 A ES 404627A ES 404627 A ES404627 A ES 404627A ES 404627 A1 ES404627 A1 ES 404627A1
Authority
ES
Spain
Prior art keywords
bromine
chlorine
phenyl
iodine atom
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES404627A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES404627A1 publication Critical patent/ES404627A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Paints Or Removers (AREA)
  • Sealing Material Composition (AREA)

Abstract

A procedure for the preparation of henzodiacapine derivatives of the general formula ** (See formula) ** in which R1 represents a hydrogen, chlorine, bromine or iodine atom or a nitro group and R2 represents a phenyl, 2-fluorophenyl or 2-chlorophenyl group, characterized by reacting a 2-haloacetamido-phenyl-ketone of the general formula ** (See formula) ** in which R1 and R2 have the same meaning that has been attributed to them before, while X represents a chlorine, bromine or iodine atom, with hexamethylenetetramine, under weakly acidic conditions and in the presence of a hydroxylic solvent containing water. (Machine-translation by Google Translate, not legally binding)
ES404627A 1971-07-08 1972-07-07 Process for the manufacture of benzodiazepine derivatives Expired ES404627A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3210771A GB1383647A (en) 1971-07-08 1971-07-08 Process for the manufacture of benzodiazepine derivatives

Publications (1)

Publication Number Publication Date
ES404627A1 true ES404627A1 (en) 1975-06-16

Family

ID=10333351

Family Applications (1)

Application Number Title Priority Date Filing Date
ES404627A Expired ES404627A1 (en) 1971-07-08 1972-07-07 Process for the manufacture of benzodiazepine derivatives

Country Status (18)

Country Link
AR (1) AR192655A1 (en)
AT (1) AT334376B (en)
AU (1) AU463475B2 (en)
BE (1) BE785962A (en)
CA (1) CA963903A (en)
CH (1) CH570388A5 (en)
DE (1) DE2233482A1 (en)
ES (1) ES404627A1 (en)
FR (1) FR2144868B1 (en)
GB (1) GB1383647A (en)
HU (1) HU168636B (en)
IE (1) IE36885B1 (en)
IL (1) IL39847A (en)
NL (1) NL167426C (en)
NO (1) NO130189B (en)
PH (1) PH10943A (en)
YU (1) YU176972A (en)
ZA (2) ZA724577B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH578544A5 (en) * 1972-08-21 1976-08-13 Hoffmann La Roche
JPS52106881A (en) * 1976-03-05 1977-09-07 Crc Ricerca Chim Production of 1*44 benzodiazepine derivative
FR2364207A1 (en) * 1976-09-09 1978-04-07 Scherico Ltd Prepn. of 1,4-benzodiazepine cpds. - by reacting e.g. a 2-haloethyl-amino-benzophenone with hexa: methylene tetr:amine in presence of an ammonium salt and water alcohol solvent
CN103804310A (en) * 2013-11-19 2014-05-21 华中药业股份有限公司 Method for preparing high-purity 7-chloro-5-phenyl-benzodiazepine-2-one

Also Published As

Publication number Publication date
CA963903A (en) 1975-03-04
FR2144868B1 (en) 1976-05-14
BE785962A (en) 1973-01-08
IE36885L (en) 1973-01-08
FR2144868A1 (en) 1973-02-16
ATA584672A (en) 1976-05-15
ZA724577B (en) 1973-03-28
NO130189B (en) 1974-07-22
GB1383647A (en) 1974-02-12
DE2233482A1 (en) 1973-01-25
NL167426C (en) 1981-12-16
ZA724639B (en) 1973-03-28
IE36885B1 (en) 1977-03-16
NL7209489A (en) 1973-01-10
CH570388A5 (en) 1975-12-15
AU4436272A (en) 1974-01-10
HU168636B (en) 1976-06-28
IL39847A0 (en) 1972-09-28
AT334376B (en) 1976-01-10
PH10943A (en) 1977-10-05
NL167426B (en) 1981-07-16
AR192655A1 (en) 1973-02-28
YU176972A (en) 1979-07-10
AU463475B2 (en) 1975-07-31
IL39847A (en) 1976-05-31

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