IE36885L - Manufacture of benzodiazepines. - Google Patents

Manufacture of benzodiazepines.

Info

Publication number
IE36885L
IE36885L IE720927A IE92772A IE36885L IE 36885 L IE36885 L IE 36885L IE 720927 A IE720927 A IE 720927A IE 92772 A IE92772 A IE 92772A IE 36885 L IE36885 L IE 36885L
Authority
IE
Ireland
Prior art keywords
benzodiazepines
july
manufacture
formula
gb1383647a
Prior art date
Application number
IE720927A
Other versions
IE36885B1 (en
Original Assignee
Roche Products Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Products Ltd filed Critical Roche Products Ltd
Publication of IE36885L publication Critical patent/IE36885L/en
Publication of IE36885B1 publication Critical patent/IE36885B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Paints Or Removers (AREA)
  • Sealing Material Composition (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

1383647 Benzodiazepines ROCHE PRODUCTS Ltd 7 July 1972 [8 July 1971] 32107/71 Heading C2C Compounds of the general formula (R<SP>1</SP>=H, Cl, Br, I, NO 2 ; R<SP>2</SP>=phenyl, o-fluorophenyl, o-chlorophenyl), are prepared by reacting a compound of the formula (X=Cl, Br, I), with hexamethylenetetramine under weak acidic conditions in the presence of a water-containing hydroxylic solvent. Reference has been directed by the Comptroller to Specifications 972,968 1,039,372 and 1,332,697. [GB1383647A]
IE927/72A 1971-07-08 1972-07-03 A process for the manufacture of benzodiazepine derivatives IE36885B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3210771A GB1383647A (en) 1971-07-08 1971-07-08 Process for the manufacture of benzodiazepine derivatives

Publications (2)

Publication Number Publication Date
IE36885L true IE36885L (en) 1973-01-08
IE36885B1 IE36885B1 (en) 1977-03-16

Family

ID=10333351

Family Applications (1)

Application Number Title Priority Date Filing Date
IE927/72A IE36885B1 (en) 1971-07-08 1972-07-03 A process for the manufacture of benzodiazepine derivatives

Country Status (18)

Country Link
AR (1) AR192655A1 (en)
AT (1) AT334376B (en)
AU (1) AU463475B2 (en)
BE (1) BE785962A (en)
CA (1) CA963903A (en)
CH (1) CH570388A5 (en)
DE (1) DE2233482A1 (en)
ES (1) ES404627A1 (en)
FR (1) FR2144868B1 (en)
GB (1) GB1383647A (en)
HU (1) HU168636B (en)
IE (1) IE36885B1 (en)
IL (1) IL39847A (en)
NL (1) NL167426C (en)
NO (1) NO130189B (en)
PH (1) PH10943A (en)
YU (1) YU176972A (en)
ZA (2) ZA724577B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH578544A5 (en) * 1972-08-21 1976-08-13 Hoffmann La Roche
JPS52106881A (en) * 1976-03-05 1977-09-07 Crc Ricerca Chim Production of 1*44 benzodiazepine derivative
FR2364207A1 (en) * 1976-09-09 1978-04-07 Scherico Ltd Prepn. of 1,4-benzodiazepine cpds. - by reacting e.g. a 2-haloethyl-amino-benzophenone with hexa: methylene tetr:amine in presence of an ammonium salt and water alcohol solvent
CN103804310A (en) * 2013-11-19 2014-05-21 华中药业股份有限公司 Method for preparing high-purity 7-chloro-5-phenyl-benzodiazepine-2-one

Also Published As

Publication number Publication date
IE36885B1 (en) 1977-03-16
ES404627A1 (en) 1975-06-16
CH570388A5 (en) 1975-12-15
HU168636B (en) 1976-06-28
FR2144868B1 (en) 1976-05-14
CA963903A (en) 1975-03-04
AT334376B (en) 1976-01-10
IL39847A (en) 1976-05-31
BE785962A (en) 1973-01-08
NL167426B (en) 1981-07-16
AR192655A1 (en) 1973-02-28
NL167426C (en) 1981-12-16
NL7209489A (en) 1973-01-10
ATA584672A (en) 1976-05-15
DE2233482A1 (en) 1973-01-25
NO130189B (en) 1974-07-22
IL39847A0 (en) 1972-09-28
YU176972A (en) 1979-07-10
AU4436272A (en) 1974-01-10
FR2144868A1 (en) 1973-02-16
GB1383647A (en) 1974-02-12
ZA724577B (en) 1973-03-28
ZA724639B (en) 1973-03-28
PH10943A (en) 1977-10-05
AU463475B2 (en) 1975-07-31

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