ES390164A1 - Procedure for preparation of new sters of meta-benzoilphenilactic acid. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for preparation of new sters of meta-benzoilphenilactic acid. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES390164A1
ES390164A1 ES390164A ES390164A ES390164A1 ES 390164 A1 ES390164 A1 ES 390164A1 ES 390164 A ES390164 A ES 390164A ES 390164 A ES390164 A ES 390164A ES 390164 A1 ES390164 A1 ES 390164A1
Authority
ES
Spain
Prior art keywords
formula
radicals
meta
general formula
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES390164A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES390164A1 publication Critical patent/ES390164A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/88—Unsaturated compounds containing keto groups containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Procedure for preparing new esters of meta-benzoylphenylacetic acid of general formula I **(See formula)** in which R1 represents a hydrogen atom or R'1, R'1 representing a lower alcohol radical; R2 and R3 represent a hydrogen atom or together represent the radical **(See formula)** P and Q representing, identical or different, an alcohol radical having 1 to 5 carbon atoms, the two benzene nuclei being mono-substituted or poly-substituted by chlorine, fluorine or bromine atoms, by alcohol radicals, by radicals alkoxyloxy, by alcoholylthio radicals or by trifluoromethyl radicals, characterized in that it is subjected to a meta-benzoylbenzoic acid of general formula III **(See formula)** in which the two benzene nuclei can be mono-substituted or poly-substituted by chlorine, fluorine or bromine atoms, by alcohol radicals, by alkoxyloxy radicals, by alcoholylthio radicals or by trifluoromethyl radicals, to the action of a homologation agent and of a dioxolane-4-methanol of general formula II: **(See formula)** wherein P and Q, identical or different, represent an alcohol radical having 1 to 5 carbon atoms, to obtain a corresponding meta-benzoylphenylacetic acid blocked polyol ester of general formula I': **(See formula)** to which it is subjected to alpha-alcoholization, if appropriate, by treatment with an alkaline basic agent chosen from the group consisting of an alkali metal hydride, an alkali metal amide or an alkali metal dialkoxylamide, and then with a alcoholization chosen from the group consisting of a compound of the formula R'1X, a compound of the formula R'SO3R'1, a compound of the formula ArSO3R'and a compound of the formula SO2 (OR'1) 2, R'1 representing an alcoholic radical lower, X a halogen atom, R'a lower alcohol radical and Ar an aromatic nucleus, to obtain the desired corresponding alpha-alkoxylated meta-benzoylphenylacetic acid blocked polyol ester of general formula I'': **(See formula)** and, where appropriate, the esters of general formulas I'and I''are hydrolyzed by means of a mineral or organic acid and the desired corresponding free polyol ester of general formula I''' is isolated: **(See formula)** in which R1 represents a hydrogen atom or a lower alcohol radical. (Machine-translation by Google Translate, not legally binding)
ES390164A 1970-04-15 1971-04-14 Procedure for preparation of new sters of meta-benzoilphenilactic acid. (Machine-translation by Google Translate, not legally binding) Expired ES390164A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7013579A FR2085638A1 (en) 1970-04-15 1970-04-15 Metabenzoyl-phenylacetic acid esters, ana-lg

Publications (1)

Publication Number Publication Date
ES390164A1 true ES390164A1 (en) 1973-07-01

Family

ID=9053997

Family Applications (1)

Application Number Title Priority Date Filing Date
ES390164A Expired ES390164A1 (en) 1970-04-15 1971-04-14 Procedure for preparation of new sters of meta-benzoilphenilactic acid. (Machine-translation by Google Translate, not legally binding)

Country Status (3)

Country Link
ES (1) ES390164A1 (en)
FR (1) FR2085638A1 (en)
ZA (1) ZA712237B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1226344A (en) * 1967-07-31 1971-03-24

Also Published As

Publication number Publication date
FR2085638B1 (en) 1973-06-08
ZA712237B (en) 1972-05-31
FR2085638A1 (en) 1971-12-31

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