GB2001959A - Substituted quinolinic acids having anti-inflammatory activity, their preparation, and their use - Google Patents

Substituted quinolinic acids having anti-inflammatory activity, their preparation, and their use

Info

Publication number
GB2001959A
GB2001959A GB7827591A GB7827591A GB2001959A GB 2001959 A GB2001959 A GB 2001959A GB 7827591 A GB7827591 A GB 7827591A GB 7827591 A GB7827591 A GB 7827591A GB 2001959 A GB2001959 A GB 2001959A
Authority
GB
United Kingdom
Prior art keywords
substituted
preparation
inflammatory activity
acids
quinolinic acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB7827591A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SIMES
SIMES Societa Italiana Medicinali e Sintetici SpA
Original Assignee
SIMES
SIMES Societa Italiana Medicinali e Sintetici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SIMES, SIMES Societa Italiana Medicinali e Sintetici SpA filed Critical SIMES
Publication of GB2001959A publication Critical patent/GB2001959A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
    • C07D215/60—N-oxides

Abstract

Compounds of the formula: <IMAGE> wherein R1, R2 and R3 are the same or different and each is hydrogen or alkyl of 1 to 4 carbon atoms, and X is in the 2- or 4-position and is OH, -Cl, -O-R4, -S-R4, -SOR4, -SO2-R4, <IMAGE> R4 is alkyl of 1 to 4 carbon atoms, or unsubstituted or substituted phenyl have anti-inflammatory properties. They may be made from the corresponding quinolylacetic acids by oxidation to the N-oxide, chlorination, and replacement of the chlorine atom by another radical X as hereinbefore defined.
GB7827591A 1977-06-22 1978-06-22 Substituted quinolinic acids having anti-inflammatory activity, their preparation, and their use Withdrawn GB2001959A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH768277A CH628892A5 (en) 1977-06-22 1977-06-22 PROCEDURE FOR THE PREPARATION OF QUINOLINIC ACIDS FOR ANTI-INFLAMMATORY ACTIVITY.

Publications (1)

Publication Number Publication Date
GB2001959A true GB2001959A (en) 1979-02-14

Family

ID=4328943

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7827591A Withdrawn GB2001959A (en) 1977-06-22 1978-06-22 Substituted quinolinic acids having anti-inflammatory activity, their preparation, and their use

Country Status (7)

Country Link
JP (1) JPS549285A (en)
BE (1) BE868359A (en)
CH (1) CH628892A5 (en)
DE (1) DE2827472A1 (en)
FR (1) FR2395262A1 (en)
GB (1) GB2001959A (en)
IT (1) IT1192259B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4555513A (en) * 1981-12-29 1985-11-26 Nippon Zoki Pharmaceutical Co. 1,2 Dihydro- and 1,2,3,4-tetrahydro quinolylacetic acids and analgesic use thereof

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3839332A1 (en) * 1988-11-22 1990-05-23 Bayer Ag METHOD FOR PRODUCING SUBSTITUTED 2-CHLORINE PYRIDINES

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3991061A (en) * 1975-07-16 1976-11-09 G. D. Searle & Co. Azanaphthaleneacetic acid derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4555513A (en) * 1981-12-29 1985-11-26 Nippon Zoki Pharmaceutical Co. 1,2 Dihydro- and 1,2,3,4-tetrahydro quinolylacetic acids and analgesic use thereof

Also Published As

Publication number Publication date
FR2395262A1 (en) 1979-01-19
CH628892A5 (en) 1982-03-31
IT7823904A0 (en) 1978-05-26
JPS549285A (en) 1979-01-24
FR2395262B1 (en) 1981-06-26
DE2827472A1 (en) 1979-01-11
BE868359A (en) 1978-10-16
IT1192259B (en) 1988-03-31

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)