ES381363A1 - Procedure for the preparation of amino acids or esters of partially protected basic amino acids. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of amino acids or esters of partially protected basic amino acids. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES381363A1
ES381363A1 ES381363A ES381363A ES381363A1 ES 381363 A1 ES381363 A1 ES 381363A1 ES 381363 A ES381363 A ES 381363A ES 381363 A ES381363 A ES 381363A ES 381363 A1 ES381363 A1 ES 381363A1
Authority
ES
Spain
Prior art keywords
amino acids
general formula
group
translation
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES381363A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of ES381363A1 publication Critical patent/ES381363A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/064—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for omega-amino or -guanidino functions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Process for the preparation of amino acids or partially protected basic amino acid esters of the general formula i ** (see formula) ** Wherein x represents an organic group containing an atom of reachable nitrogen, ac represents an acyl radical linked to the aforementioned nitrogen atom and r represents hydrogen or an alkyl group of 1 to 5 carbon atoms, and their salts by addition of acid or optionally internal salts of the free carboxylic acids, characterized in that an alpha-amino acid containing another basic radical of the general formula ii is transformed ** (see formula) ** Wherein x has the above meaning, in a manner known per se, in a metal complex derivative, advantageously derived from copper complex which contains, in protected form, the alpha-amino group and the carboxyl group, then it is acylated with an agent of acylation suitable for the introduction of the desired acyl radical ac into the final product, conveniently with an acid chloride of the general formula ac-cl, or with an acyl group derivative ac containing the carboxyl function in activated form, then decomposes the metal complex in a known manner, and, if desired, the obtained compound of the general formula i, which in the place of r contains a hydrogen atom, is esterified with an appropriate agent for the introduction of an alkyl group of 1 to 5 atoms of carbon and/or the product obtained is converted into a salt, advantageously in a salt by the addition of therapeutically usable acid. (Machine-translation by Google Translate, not legally binding)
ES381363A 1969-07-03 1970-07-02 Procedure for the preparation of amino acids or esters of partially protected basic amino acids. (Machine-translation by Google Translate, not legally binding) Expired ES381363A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HURI000374 1969-07-03

Publications (1)

Publication Number Publication Date
ES381363A1 true ES381363A1 (en) 1972-11-01

Family

ID=11000829

Family Applications (1)

Application Number Title Priority Date Filing Date
ES381363A Expired ES381363A1 (en) 1969-07-03 1970-07-02 Procedure for the preparation of amino acids or esters of partially protected basic amino acids. (Machine-translation by Google Translate, not legally binding)

Country Status (8)

Country Link
AT (1) AT302351B (en)
BE (1) BE752845A (en)
CA (1) CA928315A (en)
DE (1) DE2032329A1 (en)
ES (1) ES381363A1 (en)
FR (1) FR2059474A1 (en)
NL (1) NL7009736A (en)
PL (1) PL81109B1 (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6717029A (en) * 1968-01-29 1969-06-17

Also Published As

Publication number Publication date
PL81109B1 (en) 1975-08-30
FR2059474B1 (en) 1974-07-12
DE2032329A1 (en) 1971-01-28
AT302351B (en) 1972-10-10
BE752845A (en) 1970-12-16
NL7009736A (en) 1971-01-05
CA928315A (en) 1973-06-12
FR2059474A1 (en) 1971-06-04

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