ES361666A1 - Procedure for the preparation of substitute phenylacetic acids. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of substitute phenylacetic acids. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES361666A1
ES361666A1 ES361666A ES361666A ES361666A1 ES 361666 A1 ES361666 A1 ES 361666A1 ES 361666 A ES361666 A ES 361666A ES 361666 A ES361666 A ES 361666A ES 361666 A1 ES361666 A1 ES 361666A1
Authority
ES
Spain
Prior art keywords
formula
alkyl
prepared
substitute
translation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES361666A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
JR Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH1789367A external-priority patent/CH485667A/en
Priority claimed from CH1789267A external-priority patent/CH487840A/en
Application filed by JR Geigy AG filed Critical JR Geigy AG
Publication of ES361666A1 publication Critical patent/ES361666A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)

Abstract

Compounds of Formula I wherein R 1 is Cl, Br, F, CF 3 , C 1-4 alkyl or C 1-4 alkoxy, R 2 and R 3 are each H, Cl, Br, F or C 1-4 alkyl and R 4 is H, Cl, Br, F C 1-4 alkyl or C 1-4 alkoxy and at least one of R 1 , R 2 and' R 3 is other than H and is ortho to the NH group, and salts thereof, are' prepared from the isotins of Formula IV either by reduction with hydrazine or semicarbazide and an alkali metal hydroxide or alcoholate according to the Wolff - Kishner method or by hydrolysis to a glyoxylic acid V which is then reduced by the same method and in each case optionally converting thesalt obtained into the free acid or other salts. Compounds of Formula IV above are prepared by cyclization of the compound of Formula III / prepared by reaction of oxalic acid chloride and the corresponding N-arylanaline derivative, some of which are obtained by decarboxylation of the corresponding ortho-carboxylic acids obtained by copper/KOH fusion of an orthochlorobenzoic acid and a substituted analine.
ES361666A 1967-12-20 1968-12-19 Procedure for the preparation of substitute phenylacetic acids. (Machine-translation by Google Translate, not legally binding) Expired ES361666A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1789367A CH485667A (en) 1967-12-20 1967-12-20 Process for the preparation of substituted phenylacetic acids
CH1789267A CH487840A (en) 1967-12-20 1967-12-20 Process for the preparation of substituted phenylacetic acids

Publications (1)

Publication Number Publication Date
ES361666A1 true ES361666A1 (en) 1970-11-16

Family

ID=25720227

Family Applications (1)

Application Number Title Priority Date Filing Date
ES361666A Expired ES361666A1 (en) 1967-12-20 1968-12-19 Procedure for the preparation of substitute phenylacetic acids. (Machine-translation by Google Translate, not legally binding)

Country Status (16)

Country Link
JP (4) JPS5220469B1 (en)
AT (1) AT284823B (en)
BE (1) BE725793A (en)
CS (2) CS151496B2 (en)
DE (1) DE1815802A1 (en)
DK (1) DK125461B (en)
ES (1) ES361666A1 (en)
FI (1) FI49600C (en)
FR (1) FR1595382A (en)
GB (1) GB1257190A (en)
IE (1) IE32591B1 (en)
IL (1) IL31296A (en)
NL (1) NL6817965A (en)
NO (1) NO125724B (en)
SE (1) SE366296B (en)
YU (1) YU32986B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS549240A (en) * 1977-06-23 1979-01-24 Asahi Chem Ind Co Ltd New derivative of phenylglycolic acid, its preparation and analgesic and antiinflammatory agent contining it as effective component
IT1112024B (en) * 1979-02-23 1986-01-13 Alcar Srl PROCESS FOR THE PREPARATION OF O. (2,6-DICHLOROANILINE) -PHENYLACETIC ACID
LU83138A1 (en) * 1981-02-16 1981-09-11 T Eckert TOPICAL PHARMACEUTICAL PREPARATIONS, CONTAINING SALTS OF ALKANCARBONIC ACIDS AND NEW CARBONIC ACID SALTS AND METHOD FOR THE PRODUCTION THEREOF
AT370721B (en) * 1981-02-24 1983-04-25 Ciba Geigy Ag METHOD FOR PRODUCING NEW SALTS OF 2- (2,6-DICHLORANILINO) -PHENYLACETIC ACID, THE
CH655507B (en) * 1983-01-12 1986-04-30
JPS6341143U (en) * 1986-09-02 1988-03-17
DE69118467T2 (en) * 1990-09-04 1996-10-17 Hitachi Chemical Co Ltd Electrophotographic element
US6355680B1 (en) 1996-02-20 2002-03-12 Exocell, Inc. Albumin-binding compounds that prevent nonenzymatic glycation and that may be used for treatment of glycation-related pathologies
FR2878522B1 (en) 2004-12-01 2008-04-18 Merck Sante Soc Par Actions Si NEW SPECIFIC INHIBITORS OF CASPAS-10
AR061623A1 (en) 2006-06-26 2008-09-10 Novartis Ag PHENYLACETIC ACID DERIVATIVES
CA2658712C (en) 2006-07-25 2018-10-02 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of diclofenac with very fast skin penetration rate
CN114539086B (en) 2022-02-25 2023-10-03 复旦大学 Synthesis method of diclofenac sodium
US11834388B2 (en) 2022-02-25 2023-12-05 Fudan University Continuous-flow preparation method of diclofenac sodium

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5220469A (en) * 1975-08-08 1977-02-16 Mitsui Toatsu Chem Inc Method for grading granule
JPS5851859B2 (en) * 1978-08-11 1983-11-18 株式会社日立製作所 Form sending device

Also Published As

Publication number Publication date
JPS5220469B1 (en) 1977-06-03
IL31296A (en) 1972-06-28
JPS5635664B1 (en) 1981-08-19
GB1257190A (en) 1971-12-15
NO125724B (en) 1972-10-23
FI49600B (en) 1975-04-30
IE32591B1 (en) 1973-09-19
JPS5526131B1 (en) 1980-07-11
NL6817965A (en) 1969-06-24
JPS5526132B1 (en) 1980-07-11
CS151495B2 (en) 1973-10-19
FI49600C (en) 1975-08-11
DK125461B (en) 1973-02-26
DE1815802A1 (en) 1969-07-10
SE366296B (en) 1974-04-22
FR1595382A (en) 1970-06-08
YU298368A (en) 1975-06-30
AT284823B (en) 1970-09-25
BE725793A (en) 1969-06-20
CS151496B2 (en) 1973-10-19
YU32986B (en) 1975-12-31
IE32591L (en) 1969-06-20
IL31296A0 (en) 1969-02-27

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