ES350574A1 - Procedimiento para la preparacion de 2,3,4,5-tetrahidro-1h-3-benzazepinas. - Google Patents

Procedimiento para la preparacion de 2,3,4,5-tetrahidro-1h-3-benzazepinas.

Info

Publication number
ES350574A1
ES350574A1 ES350574A ES350574A ES350574A1 ES 350574 A1 ES350574 A1 ES 350574A1 ES 350574 A ES350574 A ES 350574A ES 350574 A ES350574 A ES 350574A ES 350574 A1 ES350574 A1 ES 350574A1
Authority
ES
Spain
Prior art keywords
radical
prepared
tetrahydro
aziridinyl
ethane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES350574A
Other languages
English (en)
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
JR Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JR Geigy AG filed Critical JR Geigy AG
Publication of ES350574A1 publication Critical patent/ES350574A1/es
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D203/00Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/08Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16Benzazepines; Hydrogenated benzazepines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Drawers Of Furniture (AREA)
ES350574A 1967-02-17 1968-02-16 Procedimiento para la preparacion de 2,3,4,5-tetrahidro-1h-3-benzazepinas. Expired ES350574A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH238667A CH481110A (de) 1967-02-17 1967-02-17 Verfahren zur Herstellung von 1,2,4,5-Tetrahydro-3-azepinen
CH1167167A CH488705A (de) 1967-02-17 1967-08-18 Verfahren zur Herstellung eines neuen Tetrahydroazepinderivates

Publications (1)

Publication Number Publication Date
ES350574A1 true ES350574A1 (es) 1969-11-16

Family

ID=25690322

Family Applications (1)

Application Number Title Priority Date Filing Date
ES350574A Expired ES350574A1 (es) 1967-02-17 1968-02-16 Procedimiento para la preparacion de 2,3,4,5-tetrahidro-1h-3-benzazepinas.

Country Status (13)

Country Link
US (1) US3652543A (enEXAMPLES)
AT (1) AT275533B (enEXAMPLES)
BE (1) BE710872A (enEXAMPLES)
CH (2) CH481110A (enEXAMPLES)
DE (2) DE1668915A1 (enEXAMPLES)
DK (1) DK115473B (enEXAMPLES)
ES (1) ES350574A1 (enEXAMPLES)
FR (2) FR1561479A (enEXAMPLES)
GB (2) GB1221324A (enEXAMPLES)
IL (1) IL29485A (enEXAMPLES)
NL (1) NL6802257A (enEXAMPLES)
NO (1) NO124369B (enEXAMPLES)
SE (1) SE342043B (enEXAMPLES)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT289812B (de) * 1968-08-09 1971-05-10 Geigy Ag J R Verfahren zur Herstellung des neuen 2-Methyl-7-chlor-2,3,4,5-tetrahydro-1H-3-benzazepins sowie seiner Säureadditionssalze
DE2016136A1 (de) * 1970-04-04 1971-10-14 C H Boehnnger Sohn, 6507 Ingel heim Neue 7 Acyl 1,2,4,5 tetrahydro (3H) 3 benzazepine
DE2143204C3 (de) * 1971-08-28 1979-09-27 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt N-Fluoralkyl-phenylisopropylamin-Derivate und deren Salze, Verfahren zu deren Herstellung und Arzneimittel auf deren Basis
FR2171879A1 (en) * 1972-02-14 1973-09-28 Pennwalt Corp 1,2,4,5-tetrahydro-3h-3-benzazepines - analgesics narcotic antagonists, antihistamines etc
EP0161350A1 (en) * 1981-11-27 1985-11-21 Smithkline Beckman Corporation Process for preparing benzazepines
US4541954A (en) * 1984-09-05 1985-09-17 Smithkline Beckman Corporation Method for preparing 6-chloro-N-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
US4973586A (en) * 1986-01-16 1990-11-27 Schering Corporation Fused benzazepines, compositions of, and medical use thereof
AU588080B2 (en) * 1986-01-16 1989-09-07 Schering Corporation Fused benzazepines
US5302716A (en) * 1986-01-16 1994-04-12 Schering Corporation Fused benzazepines
US5015639A (en) * 1987-03-27 1991-05-14 Schering Corporation Substituted benzazepines, their preparation and pharmaceutical compositions containing them
WO1989000561A1 (en) * 1987-07-15 1989-01-26 Schering Corporation Fused benzazepines
AU646432B2 (en) * 1990-02-02 1994-02-24 Schering Corporation 4,5-cycloalkano-3-benzazepin-7-ol-derivatives and their use
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
US20030220661A1 (en) * 2002-05-21 2003-11-27 Heartstent Corporation Transmyocardial implant delivery system
US7704993B2 (en) * 2003-06-17 2010-04-27 Arena Pharmaceuticals, Inc. Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
JP4920409B2 (ja) * 2003-06-17 2012-04-18 アリーナ ファーマシューティカルズ, インコーポレイテッド 3−ベンズアゼピンを調製する方法
US20080009478A1 (en) * 2003-10-22 2008-01-10 Arena Pharmaceuticals, Inc. Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2c Receptor Associated Diseases
US20070275949A1 (en) * 2003-10-22 2007-11-29 Arena Pharmaceuticals, Inc. Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2C Receptor Associated Diseases
KR101281919B1 (ko) 2004-12-21 2013-07-03 아레나 파마슈티칼스, 인크. (r)-8-클로로-1-메틸-2,3,4,5-테트라히드로-1h-3-벤즈아제핀 히드로클로라이드의 결정질 형태
EP2322162A1 (en) 2004-12-23 2011-05-18 Arena Pharmaceuticals, Inc. 5HT2C receptor modulator compositions and methods of use
WO2007120517A2 (en) 2006-04-03 2007-10-25 Arena Pharmaceuticals, Inc. Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates related thereto
JP5404414B2 (ja) * 2006-12-05 2014-01-29 アリーナ ファーマシューティカルズ, インコーポレイテッド (r)−8−クロロ−1−メチル−2,3,4,5−テトラヒドロ−1h−3−ベンゾアゼピンおよびその中間体を調製するための方法
US8822727B2 (en) * 2008-03-04 2014-09-02 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
WO2010148207A2 (en) 2009-06-18 2010-12-23 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-ht2c receptor agonists
WO2011071136A1 (ja) 2009-12-11 2011-06-16 アステラス製薬株式会社 線維筋痛症治療剤
KR20130112848A (ko) 2010-06-02 2013-10-14 아레나 파마슈티칼스, 인크. 5-ht2c 수용체 아고니스트의 제조 방법
US9365521B2 (en) 2010-09-01 2016-06-14 Arena Pharmaceuticals, Inc. Non-hygroscopic salts of 5-HT2C agonists
NZ608266A (en) 2010-09-01 2015-09-25 Arena Pharm Inc Administration of lorcaserin to individuals with renal impairment
JP2013539470A (ja) 2010-09-01 2013-10-24 アリーナ ファーマシューティカルズ, インコーポレイテッド ロルカセリンと光学活性な酸との塩
SG10201506874UA (en) 2010-09-01 2015-10-29 Arena Pharm Inc Modified-release dosage forms of 5-ht2c agonists useful for weight management
AR088670A1 (es) 2012-10-09 2014-06-25 Arena Pharm Inc Metodo de control del peso

Also Published As

Publication number Publication date
IL29485A (en) 1971-07-28
CH488705A (de) 1970-04-15
FR1561479A (enEXAMPLES) 1969-03-28
DE1668915A1 (de) 1972-03-09
GB1222397A (en) 1971-02-10
GB1221324A (en) 1971-02-03
NL6802257A (enEXAMPLES) 1968-08-19
NO124369B (enEXAMPLES) 1972-04-10
FR1560654A (enEXAMPLES) 1969-03-21
AT275533B (de) 1969-10-27
DE1695124A1 (de) 1970-08-20
DK115473B (da) 1969-10-13
US3652543A (en) 1972-03-28
SE342043B (enEXAMPLES) 1972-01-24
CH481110A (de) 1969-11-15
BE710872A (enEXAMPLES) 1968-08-16

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