ES340132A1 - Ampicillin trihydrate - Google Patents

Ampicillin trihydrate

Info

Publication number
ES340132A1
ES340132A1 ES340132A ES340132A ES340132A1 ES 340132 A1 ES340132 A1 ES 340132A1 ES 340132 A ES340132 A ES 340132A ES 340132 A ES340132 A ES 340132A ES 340132 A1 ES340132 A1 ES 340132A1
Authority
ES
Spain
Prior art keywords
ampicillin
water
trihydrate
produce
organic solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES340132A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxochem SpA
Original Assignee
Ankerfarm SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ankerfarm SpA filed Critical Ankerfarm SpA
Publication of ES340132A1 publication Critical patent/ES340132A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Ampicillin trihydrate is prepared by precipitating ampicillin in the form of a hydrate thereof containing at least one but less than three molecules of water per molecule of ampicillin from a solution of ampicillin in an aqueous water-miscible polar organic solvent medium, said medium containing up to 20% by volume of water and subsequently treating the resulting precipitate with an excess of water to produce ampicillin trihydrate. Ampicillin may be dissolved in aqueous acetone at pH 1 to 4, clarified and an inorganic or organic base added to pH 4 to 7 until a precipitate forms. This is washed with an organic solvent and then treated with excess water in order to produce the trihydrate.
ES340132A 1967-03-08 1967-05-03 Ampicillin trihydrate Expired ES340132A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1345067 1967-03-08

Publications (1)

Publication Number Publication Date
ES340132A1 true ES340132A1 (en) 1968-08-16

Family

ID=11144453

Family Applications (1)

Application Number Title Priority Date Filing Date
ES340132A Expired ES340132A1 (en) 1967-03-08 1967-05-03 Ampicillin trihydrate

Country Status (8)

Country Link
AT (1) AT287192B (en)
DE (1) DE1645980A1 (en)
DK (1) DK119979B (en)
ES (1) ES340132A1 (en)
FR (1) FR1557644A (en)
GB (1) GB1216714A (en)
GR (1) GR37429B (en)
NL (1) NL6705789A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3703511A (en) * 1969-06-06 1972-11-21 Squibb & Sons Inc Alpha-aminobenzyl penicillins
JPS6379888A (en) * 1986-09-24 1988-04-09 Tanabe Seiyaku Co Ltd Stable hydrate of penicillin derivative
AR062927A1 (en) 2006-10-11 2008-12-17 Bayer Healthcare Ag 4- [4- ([[4- CHLORINE-3- (TRIFLUOROMETILE) PHENYL) CARBAMOIL] AMINO] -3- FLUOROPHENOXY) -N- METHYLPIRIDIN-2-MONOHIDRATED CARBOXAMIDE

Also Published As

Publication number Publication date
FR1557644A (en) 1969-02-21
DK119979B (en) 1971-03-22
GR37429B (en) 1969-05-29
AT287192B (en) 1971-01-11
DE1645980A1 (en) 1970-07-16
NL6705789A (en) 1968-09-09
GB1216714A (en) 1970-12-23

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