ES299426A1 - Procedure for obtaining new derivatives of bio and semisynthetic penicillines (Machine-translation by Google Translate, not legally binding)
- Google Patents
Procedure for obtaining new derivatives of bio and semisynthetic penicillines (Machine-translation by Google Translate, not legally binding)
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ANTIBIETICOS SOC ANENIMA
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ANTIBIETICOS SOC ANENIMA
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Priority to ES0299426ApriorityCriticalpatent/ES299426A1/en
Publication of ES299426A1publicationCriticalpatent/ES299426A1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Medicinal Preparation
(AREA)
Abstract
Process for obtaining new salts of penicillins with tetracycline derivatives obtained by the Mannich reaction, characterized in that an aqueous solution of a penicillin salt is treated with an acid, preferably inorganic, whereby the corresponding penicillinic acid is released, to a Variable pH according to the stability in an acid medium of the penicillin in question, and once the acid is released, it is extracted with an organic solvent not miscible with water and that by a subsequent addition of a solvent of the tetracycline derivative allows to obtain a homogeneous solution to which is then added said tetracycline derivative which will remain in solution, the desired product being isolated by precipitation by the known method consisting in adding said solution to a solvent which is miscible with it and in which the penicillin of the tetracycline base is insoluble. (Machine-translation by Google Translate, not legally binding)
ES0299426A1964-04-301964-04-30Procedure for obtaining new derivatives of bio and semisynthetic penicillines (Machine-translation by Google Translate, not legally binding)
ExpiredES299426A1
(en)
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