ES314222A1 - Procedure for the preparation of polycyclic compounds of pharmaceutical action. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of polycyclic compounds of pharmaceutical action. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES314222A1
ES314222A1 ES0314222A ES314222A ES314222A1 ES 314222 A1 ES314222 A1 ES 314222A1 ES 0314222 A ES0314222 A ES 0314222A ES 314222 A ES314222 A ES 314222A ES 314222 A1 ES314222 A1 ES 314222A1
Authority
ES
Spain
Prior art keywords
compound
group
formula
see formula
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0314222A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES314222A1 publication Critical patent/ES314222A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Process for the preparation of polycyclic compounds of pharmaceutical action, characterized by cyclizing a tetrahydro-isoquinoline compound of the general formula ** (See formula) ** wherein R1 and R2 represent hydrogen, lower alkyl, aralkyl or lower alkanoyl, or R1 or R2, together, represent methylene, R3 represents hydrogen, lower alkyl, lower alkenyl, aralkyl, the acyl group of a lower or aromatic aliphatic carboxylic acid, cycloalkilalkyl or dialkylamino-alkyl and X represents the carboxyl group, a halogencarbonyl group, the carbamyl group, the cyano group or a carboalkoxy, carbonyloxy or carboaralkoxy group, or an acid addition salt, a quaternary salt, a quaternary base or an N-oxide of said compound, to form a compound of the general formula ** (See formula) ** by introducing, if desired, a substituent R3 into a compound thus obtained wherein R3 is hydrogen and by converting, if desired, the product of the cyclization, passing through a compound of the general formula ** (See formula) ** where R4 represents a grouping of the formula ** (See formula) ** or a grouping of the formula ** (See formula) ** where R4a represents hydrogen; a carboalkoxy group, a carbaryloxy group or a carboaralkoxy group and R 4b represents an alkyl group, in a compound of the general formula ** (See formula) ** or a salt of said compound, with the proviso that at any time before the conversion of a compound of the formula III into a compound of the formula IV, a tricyclic compound obtained is converted, if desired, into its N-oxide and that at any time the alkoxy groups that are in position 5 and/or 6 are converted, if desired, into hydroxy groups and/or the hydroxy groups are converted, if desired, into acyloxy groups. (Machine-translation by Google Translate, not legally binding)
ES0314222A 1964-06-16 1965-06-15 Procedure for the preparation of polycyclic compounds of pharmaceutical action. (Machine-translation by Google Translate, not legally binding) Expired ES314222A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH786164A CH446341A (en) 1964-06-16 1964-06-16 Process for the preparation of cyclopent (ij) isoquinoline derivatives

Publications (1)

Publication Number Publication Date
ES314222A1 true ES314222A1 (en) 1966-04-01

Family

ID=4331519

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0314222A Expired ES314222A1 (en) 1964-06-16 1965-06-15 Procedure for the preparation of polycyclic compounds of pharmaceutical action. (Machine-translation by Google Translate, not legally binding)

Country Status (7)

Country Link
BE (1) BE665445A (en)
CH (1) CH446341A (en)
DE (1) DE1545945A1 (en)
ES (1) ES314222A1 (en)
FR (2) FR1443504A (en)
GB (1) GB1054095A (en)
NL (1) NL6507700A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4198414A (en) * 1977-12-29 1980-04-15 A. H. Robins Company, Inc. Compounds and methods for treating diabetic complications
GB2218900B (en) * 1988-05-25 1992-09-02 Arthur Cattanach Potter Cutting board

Also Published As

Publication number Publication date
CH446341A (en) 1967-11-15
FR4532M (en) 1966-11-28
DE1545945A1 (en) 1969-12-11
GB1054095A (en) 1967-01-14
BE665445A (en) 1965-12-15
FR1443504A (en) 1966-06-24
NL6507700A (en) 1965-12-17

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