ES300712A1 - Procedure for the preparation of benzo derivatives [a] quinolizin (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of benzo derivatives [a] quinolizin (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES300712A1
ES300712A1 ES300712A ES300712A ES300712A1 ES 300712 A1 ES300712 A1 ES 300712A1 ES 300712 A ES300712 A ES 300712A ES 300712 A ES300712 A ES 300712A ES 300712 A1 ES300712 A1 ES 300712A1
Authority
ES
Spain
Prior art keywords
group
formula
translation
preparation
legally binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES300712A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES300712A1 publication Critical patent/ES300712A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
    • C07D455/08—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems having an isoquinolyl-1, a substituted isoquinolyl-1 or an alkylenedioxyisoquinolyl-1 radical linked through only one carbon atom, attached in position 2, e.g. emetine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Process for the preparation of benzo [a] quinolizine derivatives, of the general formula ** (See formula) ** where R represents hydrogen, a lower aralkyl group, a lower alkyl group or a lower alkenyl group; X is hydrogen, the carboxy group, a lower carboalkoxy group or cyano; m and n are each integers from 1 to 4; R1, R2 and R3 are, individually, lower alkyl, and when mon is greater than 1, two adjacent groups R1O and/or two adjacent groups R3O can form a lower alkylenedioxy group, characterized by reacting a salt of 6.7-dihydro -benzo [a] quinolizinium, provided with a cation of the general formula ** (See formula) ** where R1, R2, X and m have the meaning stated above, with a 3,4-dihydro-isoquinolinium salt having a cation of the general formula ** (See formula) ** where R3 and n have the meaning set forth above and R4 is a lower aralkyl group, a lower alkyl group or a lower alkenyl group, by decarboxylating, or by saponifying and decarboxylating, if required, the product of the reaction when a compound of the formula II is used as the starting compound in which X means the carboxyl group, a carboalkoxy group or the cyano group, and hydrogenating in the C ring the resulting product, before or after a possible cleavage or reduction of the R4 substituent. (Machine-translation by Google Translate, not legally binding)
ES300712A 1963-06-07 1964-06-06 Procedure for the preparation of benzo derivatives [a] quinolizin (Machine-translation by Google Translate, not legally binding) Expired ES300712A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH704063A CH450414A (en) 1963-06-07 1963-06-07 Process for the preparation of benzo (a) quinolizine derivatives

Publications (1)

Publication Number Publication Date
ES300712A1 true ES300712A1 (en) 1964-11-16

Family

ID=4318976

Family Applications (1)

Application Number Title Priority Date Filing Date
ES300712A Expired ES300712A1 (en) 1963-06-07 1964-06-06 Procedure for the preparation of benzo derivatives [a] quinolizin (Machine-translation by Google Translate, not legally binding)

Country Status (4)

Country Link
CH (1) CH450414A (en)
DK (1) DK107558C (en)
ES (1) ES300712A1 (en)
OA (1) OA00961A (en)

Also Published As

Publication number Publication date
CH450414A (en) 1968-01-31
OA00961A (en) 1968-08-07
DK107558C (en) 1967-06-12

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