ES351581A1 - Procedure for preparing steroid compositions of powerful analgesic activity. (Machine-translation by Google Translate, not legally binding)
- Google Patents
Procedure for preparing steroid compositions of powerful analgesic activity. (Machine-translation by Google Translate, not legally binding)
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GD Searle LLC
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GD Searle LLC
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Preparation process of 17-oxygenate-3-atoxy-6- (aminomethyl-disubstituted) pregna 3,5-dien-20-ones of the general formula ** (see formula) ** Wherein r and r'can be alkyl, alkanoyl or aikalkylene alkylene radicals, x' can be a hydrogen atom or a chloro, fluoro or acetoxy substituent, r "is acetyl when x'is a chloro or bromo substituent; r "is hydrogen or an acetyl radical when x'is an acetoxy group and r" can also be acetyl when x' is hydrogen and r and r'are non-identical functions, which process is characterized by the reductive amination of a compound of general formula ** (see formula) ** Wherein r "and x'are as defined above, employing a primary amine and molecular oxygen in the presence of a hydrogenation catalyst, to produce the corresponding 6- (N- (monosubstituted) -aminomethyl) pregnadiene, followed by: A) alkylation with an alkyl halide when the 6- (h, N-dialkylamino-methyl) derivatives are desired, B) acylation with an anhydride or alkanoic acid, when the 6- (N-alkanoyl-N-alkylaminomethyl) derivatives are desired, or C) acylation of the 6-hydroxyalkomino-methyl products of the reductive amination, the 6- (N-alkanoyl-N-alkanoyloxyalkylaminomethyl) derivatives are desired. (Machine-translation by Google Translate, not legally binding)
ES351581A1968-05-141968-05-14Procedure for preparing steroid compositions of powerful analgesic activity. (Machine-translation by Google Translate, not legally binding)
ExpiredES351581A1
(en)
Preparation procedure of 17-oxygenated-3-etoxy-6- (a- minometil-disused) pregna-3,5-dien-20-onas. (Machine-translation by Google Translate, not legally binding)
Derivatives of 3-ethoxycarbonyl-5-hydroxy-2-methyl-4-piperazino methyl substituted indoles their processes of preparation and their therapeutic application