ES304833A1 - Imidazole derivatives - Google Patents

Imidazole derivatives

Info

Publication number
ES304833A1
ES304833A1 ES0304833A ES304833A ES304833A1 ES 304833 A1 ES304833 A1 ES 304833A1 ES 0304833 A ES0304833 A ES 0304833A ES 304833 A ES304833 A ES 304833A ES 304833 A1 ES304833 A1 ES 304833A1
Authority
ES
Spain
Prior art keywords
hydrogen atom
formula
nitroimidazole
acid
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0304833A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc SA
Original Assignee
Rhone Poulenc SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc SA filed Critical Rhone Poulenc SA
Publication of ES304833A1 publication Critical patent/ES304833A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Vessels And Coating Films For Discharge Lamps (AREA)

Abstract

Novel compounds of formula <FORM:1079271/C2/1> wherein R1 represents an alkyl group containing 1-6 carbon atoms, and R2 is a hydrogen atom, or an alkyl group having 1-5 carbon atoms, and acid-addition salts thereof, are prepared by reacting in the absence of a basic condensing agent an N1-unsubstituted nitroimidazole with a compound of formula Z-CH2-CH(R1)-OY wherein Z represents the acid residue of a reactive ester and Y represents a hydrogen atom or a radical which protects the hydroxyl group during the reaction, and is readily replaceable by a hydrogen atom, and, where Y is other than a hydrogen atom liberating the hydroxyl group, or by reacting the N1-unsubstituted nitroimidazole with a 1,2-alkyleneoxide in a liquid medium containing, or consisting of, at least one organic acid which is a solvent for the nitroimidazole. Therapeutic compositions having amoebicidal or trichomonacidal activity which may be administered orally, parenterally or locally contain as active ingredient compounds of Formula I above or a non-toxic acid addition salt thereof.
ES0304833A 1963-10-10 1964-10-10 Imidazole derivatives Expired ES304833A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR950193A FR1427627A (en) 1963-10-10 1963-10-10 New imidazole derivatives and their preparation

Publications (1)

Publication Number Publication Date
ES304833A1 true ES304833A1 (en) 1965-03-16

Family

ID=8814114

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0304833A Expired ES304833A1 (en) 1963-10-10 1964-10-10 Imidazole derivatives

Country Status (17)

Country Link
AT (1) AT248426B (en)
BE (1) BE654213A (en)
BR (1) BR6463188D0 (en)
CH (1) CH429740A (en)
CY (1) CY561A (en)
DE (1) DE1470208B1 (en)
DK (1) DK114485B (en)
ES (1) ES304833A1 (en)
FI (1) FI44406B (en)
FR (1) FR1427627A (en)
GB (1) GB1079271A (en)
LU (1) LU47117A1 (en)
MY (1) MY7100029A (en)
NL (1) NL6411717A (en)
NO (1) NO120633B (en)
OA (1) OA00497A (en)
SE (1) SE323385B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3987053A (en) * 1971-07-30 1976-10-19 Gruppo Lepetit S.P.A. 2-nitroimidazol derivatives
GB2195536A (en) * 1986-10-06 1988-04-13 Petrolite Corp Bactericide compositions containing nitroimadazole salts
FR2625998B1 (en) * 1988-01-15 1990-06-08 Rhone Poulenc Sante PROCESS FOR THE PREPARATION OF HYDROXYALKYL-1 METHYL-2 NITRO-5 IMIDAZOLES
ZA9410186B (en) * 1994-01-10 1995-08-25 Santiago Abelardo Bojali Jaber Savourless antiamoebic antiprotozoan chemical product and procedure to obtain it

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT205028B (en) * 1958-02-27 1959-08-25 Rhone Poulenc Sa Process for the production of new imidazole derivatives

Also Published As

Publication number Publication date
DE1470208B1 (en) 1970-09-24
NL6411717A (en) 1965-04-12
CY561A (en) 1970-10-09
DK114485B (en) 1969-07-07
NO120633B (en) 1970-11-16
LU47117A1 (en) 1964-12-09
OA00497A (en) 1966-07-15
BR6463188D0 (en) 1973-07-17
MY7100029A (en) 1971-12-31
BE654213A (en) 1965-04-09
AT248426B (en) 1966-07-25
FI44406B (en) 1971-08-02
SE323385B (en) 1970-05-04
FR1427627A (en) 1966-02-11
CH429740A (en) 1967-02-15
GB1079271A (en) 1967-08-16

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