GB1062448A - Derivatives of uracil and method of preparing the same - Google Patents

Derivatives of uracil and method of preparing the same

Info

Publication number
GB1062448A
GB1062448A GB32366/64A GB3236664A GB1062448A GB 1062448 A GB1062448 A GB 1062448A GB 32366/64 A GB32366/64 A GB 32366/64A GB 3236664 A GB3236664 A GB 3236664A GB 1062448 A GB1062448 A GB 1062448A
Authority
GB
United Kingdom
Prior art keywords
alkyl
uracil
derivatives
preparing
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB32366/64A
Inventor
Herbert Partenheimer
Karlash Kumar Gauri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Robugen GmbH
Original Assignee
Robugen GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robugen GmbH filed Critical Robugen GmbH
Priority to GB32366/64A priority Critical patent/GB1062448A/en
Publication of GB1062448A publication Critical patent/GB1062448A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

New compounds of Formula I <FORM:1062448/C2/1> where R1 is lower (i.e. 1-6 C) alkyl or b -chloroethyl, R2 is alkyl, cycloalkyl, aralkyl, alkenyl or aryl, and X is hydrogen or chlorine, and their pharmaceutically acceptable acid addition salts, are prepared by chlorination of compounds II where R3 is lower alkyl or b -hydroxyethyl <FORM:1062448/C2/2> (preparable from uracils, HCHO and R3NHCH2CH2OH): also described is hydrogenation to replace a chlorine atom X. Pharmaceutical compositions comprise the new compounds with carriers, being useful as cytostatic agents.
GB32366/64A 1964-08-07 1964-08-07 Derivatives of uracil and method of preparing the same Expired GB1062448A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB32366/64A GB1062448A (en) 1964-08-07 1964-08-07 Derivatives of uracil and method of preparing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB32366/64A GB1062448A (en) 1964-08-07 1964-08-07 Derivatives of uracil and method of preparing the same

Publications (1)

Publication Number Publication Date
GB1062448A true GB1062448A (en) 1967-03-22

Family

ID=10337500

Family Applications (1)

Application Number Title Priority Date Filing Date
GB32366/64A Expired GB1062448A (en) 1964-08-07 1964-08-07 Derivatives of uracil and method of preparing the same

Country Status (1)

Country Link
GB (1) GB1062448A (en)

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