ES3011833T3 - Engineered tgf-beta monomers and their use for inhibiting tgf-beta signaling - Google Patents

Engineered tgf-beta monomers and their use for inhibiting tgf-beta signaling Download PDF

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Publication number
ES3011833T3
ES3011833T3 ES17871472T ES17871472T ES3011833T3 ES 3011833 T3 ES3011833 T3 ES 3011833T3 ES 17871472 T ES17871472 T ES 17871472T ES 17871472 T ES17871472 T ES 17871472T ES 3011833 T3 ES3011833 T3 ES 3011833T3
Authority
ES
Spain
Prior art keywords
tgf
residue
monomer
amino acid
substitution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES17871472T
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English (en)
Spanish (es)
Inventor
Andrew Hinck
Traian Sulea
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Research Council of Canada
University of Pittsburgh
Original Assignee
National Research Council of Canada
University of Pittsburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ES17871472T 2016-11-18 2017-11-17 Engineered tgf-beta monomers and their use for inhibiting tgf-beta signaling Active ES3011833T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662423920P 2016-11-18 2016-11-18
PCT/US2017/062233 WO2018094173A1 (en) 2016-11-18 2017-11-17 Engineered tgf-beta monomers and their use for inhibiting tgf-beta signaling

Publications (1)

Publication Number Publication Date
ES3011833T3 true ES3011833T3 (en) 2025-04-08

Family

ID=62146703

Family Applications (1)

Application Number Title Priority Date Filing Date
ES17871472T Active ES3011833T3 (en) 2016-11-18 2017-11-17 Engineered tgf-beta monomers and their use for inhibiting tgf-beta signaling

Country Status (6)

Country Link
US (2) US11091523B2 (https=)
EP (1) EP3541409B1 (https=)
JP (3) JP7079779B2 (https=)
ES (1) ES3011833T3 (https=)
PT (1) PT3541409T (https=)
WO (1) WO2018094173A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018094173A1 (en) * 2016-11-18 2018-05-24 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Engineered tgf-beta monomers and their use for inhibiting tgf-beta signaling
US20220409684A1 (en) * 2019-11-18 2022-12-29 The Brigham And Women's Hospital, Inc. Codon optimized new generation regulatable fusogenic oncolytic herpes simplex virus type 1 virus and methods of use
WO2022047220A1 (en) * 2020-08-27 2022-03-03 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Oncolytic viruses encoding recombinant tranforming growth factor (tgf)-beta monomers and uses thereof
WO2022139493A1 (ko) * 2020-12-23 2022-06-30 한국과학기술연구원 TGF-β 신호전달을 억제할 수 있는 신규한 펩타이드 및 이의 용도
CN118103390A (zh) * 2021-10-11 2024-05-28 联邦高等教育系统匹兹堡大学 工程化TGF-β单体及其使用方法
JP2024096518A (ja) * 2023-01-03 2024-07-16 エフビーデー バイオロジクス リミテッド 操作されたｔｇｆｂｒｉｉバリアント及びその使用方法
JP2026503849A (ja) * 2023-01-30 2026-01-30 シアトル チルドレンズ ホスピタル ディー／ビー／エイ シアトル チルドレンズ リサーチ インスティテュート 免疫細胞の機能を増強するための誘導型サイトカイン導入遺伝子
KR20260019369A (ko) 2023-05-31 2026-02-10 에프비디 바이올로직스 리미티드 Cd47/pd-l1-표적화 단백질 복합체 및 그의 사용 방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5766897A (en) * 1990-06-21 1998-06-16 Incyte Pharmaceuticals, Inc. Cysteine-pegylated proteins
US5595756A (en) * 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
EP1668133A4 (en) 2003-09-05 2007-08-29 Ca Nat Research Council BISPIRALEE HYBRID PROTEIN WITH DOMAINS OF CELL RECEPTORS
WO2011094749A2 (en) 2010-02-01 2011-08-04 Board Of Regents, The University Of Texas System Small molecule inhibitors that block assembly of the tgf-beta signaling complex
CU24181B1 (es) 2012-11-09 2016-04-25 Ct De Inmunología Molecular POLIPÉPTIDOS DERIVADOS DEL TGFß
WO2018094173A1 (en) 2016-11-18 2018-05-24 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Engineered tgf-beta monomers and their use for inhibiting tgf-beta signaling

Also Published As

Publication number Publication date
CA3041727A1 (en) 2018-05-24
EP3541409A4 (en) 2020-06-17
JP7079779B2 (ja) 2022-06-02
US20190359667A1 (en) 2019-11-28
JP2022033239A (ja) 2022-02-28
JP7623273B2 (ja) 2025-01-28
JP2020500511A (ja) 2020-01-16
US20210332096A1 (en) 2021-10-28
US12428460B2 (en) 2025-09-30
EP3541409A1 (en) 2019-09-25
US11091523B2 (en) 2021-08-17
PT3541409T (pt) 2025-02-13
EP3541409B1 (en) 2025-01-22
JP2023164748A (ja) 2023-11-10
WO2018094173A1 (en) 2018-05-24

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