ES299767A1 - Procedure for the manufacture of [1,2-alpha] imidazopirins and their acid addiction salts (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the manufacture of [1,2-alpha] imidazopirins and their acid addiction salts (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES299767A1
ES299767A1 ES299767A ES299767A ES299767A1 ES 299767 A1 ES299767 A1 ES 299767A1 ES 299767 A ES299767 A ES 299767A ES 299767 A ES299767 A ES 299767A ES 299767 A1 ES299767 A1 ES 299767A1
Authority
ES
Spain
Prior art keywords
products
alpha
translation
manufacture
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES299767A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorio Bioterapico Milanese Selvi & C S A S
Original Assignee
Laboratorio Bioterapico Milanese Selvi & C S A S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorio Bioterapico Milanese Selvi & C S A S filed Critical Laboratorio Bioterapico Milanese Selvi & C S A S
Publication of ES299767A1 publication Critical patent/ES299767A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Process for the manufacture of [1,2-alpha] imidazopyridines, and their acid addition salts, of the general formula: **(See formula)** wherein R1 is a hydrogen atom or a lower alkyl radical or a lower alkoxy radical at positions 5, 6, 7, 8 of the imidazopyridine nucleus; R2 is a hydrogen atom or a dialkylaminomethyl group of the formula: **(See formula)** wherein R4 and R5 individually represent alkyl groups or, together with the nitrogen atom to which they are attached, a 5- or 6-membered heterocyclic ring, such as pyrrolidino, piperidino, morpholino, piperazino, methylpiperazino or beta-oxietilpiperacino; R3 is an alkylmercapto, alkylsulfoxy or lower alkylsulfonyl group, in positions 2', 3', 4'of the benzene nucleus, characterized in that it comprises the reaction of a 2-aminopyridine substituted with a group represented by R1, with a halogen-acetophanone, substituted in the phenyl ring with a group represented by R3, following the conditions of the Tschitschibabin reaction, thus obtaining the products of the general formula where R2 = H and condensing these products with formaldehyde and amines, following the conditions of the reaction Mannich to obtain the products of the general formula where R2 is a dialkylaminomethyl group as indicated above. (Machine-translation by Google Translate, not legally binding)
ES299767A 1963-04-30 1964-04-30 Procedure for the manufacture of [1,2-alpha] imidazopirins and their acid addiction salts (Machine-translation by Google Translate, not legally binding) Expired ES299767A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT3450563 1963-04-30

Publications (1)

Publication Number Publication Date
ES299767A1 true ES299767A1 (en) 1964-12-01

Family

ID=11239672

Family Applications (1)

Application Number Title Priority Date Filing Date
ES299767A Expired ES299767A1 (en) 1963-04-30 1964-04-30 Procedure for the manufacture of [1,2-alpha] imidazopirins and their acid addiction salts (Machine-translation by Google Translate, not legally binding)

Country Status (2)

Country Link
ES (1) ES299767A1 (en)
GB (1) GB991589A (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2568880B1 (en) * 1984-08-07 1986-12-12 Synthelabo IMIDAZO ACYLAMINOMETHYL-3 DERIVATIVES (1,2-A) PYRIDINES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2593180B1 (en) * 1986-01-22 1990-10-26 Synthelabo IMIDAZO (1,2-A) QUINOLEINS ACYLAMINOMETHYL-1 DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
EP0234970B1 (en) * 1986-01-22 1991-04-17 Synthelabo 3-Acylaminomethylimidazo[1,2-a]pyrimidine derivatives, their preparation and therapeutical use of same
FR2593818B1 (en) * 1986-02-05 1988-04-29 Synthelabo IMIDAZO (1,2-A) PYRIDINE ACYLAMINOMETHYL-3 DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2593181B1 (en) * 1986-01-22 1988-04-01 Synthelabo IMIDAZO ACYLAMINOMETHYL-3 DERIVATIVES (1,2-A) PYRIDINES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
DE10247271A1 (en) * 2002-10-10 2004-08-26 Grünenthal GmbH Use of new and known 7-(methyl or trifluoromethyl)-imidazo-(1,2-a)-pyridines as nitrogen monoxide synthase inhibitors useful e.g. for treating migraine, neurodegenerative diseases, inflammatory pain, diabetes or cancer
EP2070927A4 (en) * 2006-09-13 2010-10-13 Kyowa Hakko Kirin Co Ltd Fused heterocyclic derivative
WO2009007995A1 (en) * 2007-07-09 2009-01-15 Suven Life Sciences Limited Process for preparing zolpidem and its intermediate
EP2300470A2 (en) * 2008-05-19 2011-03-30 Sepracor Inc. Imidazo[1,2-a]pyridine compounds as gaba-a receptor modulators
WO2010074753A1 (en) 2008-12-23 2010-07-01 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds

Also Published As

Publication number Publication date
GB991589A (en) 1965-05-12

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