ES277369A1 - A procedure for preparing 2-aril-4,7-diamino-N-disubstituºdo-aminoalcohil-6-pteridincarboxamidas (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure for preparing 2-aril-4,7-diamino-N-disubstituºdo-aminoalcohil-6-pteridincarboxamidas (Machine-translation by Google Translate, not legally binding)

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Publication number
ES277369A1
ES277369A1 ES277369A ES277369A ES277369A1 ES 277369 A1 ES277369 A1 ES 277369A1 ES 277369 A ES277369 A ES 277369A ES 277369 A ES277369 A ES 277369A ES 277369 A1 ES277369 A1 ES 277369A1
Authority
ES
Spain
Prior art keywords
formula
see formula
see
radical
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES277369A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Publication of ES277369A1 publication Critical patent/ES277369A1/en
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/10—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with an aromatic or hetero-aromatic ring directly attached in position 2

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A process for preparing 2-aryl-4,7-diamino-N-disubstituted-aminoalcohyl-6-pteridine carboxamides of the structural formula: ** (See formula) ** where Ar represents an aryl radical which is unsubstituted or which carries a trifluoromethyl, lower alkyl, lower alkoxy or halogen substituent; R and R 'are the same or different and are hydrogen atoms or lower alkyl groups; n is one or two; and R "and R" '' are alkyl radicals or hydroxyalkyl groups of one to four carbon atoms, or R '' and R '' 'together constitute a divalent radical that completes a heterocyclic ring of the pyrrolidine series, piperidine or morpholine; and for preparing the salts by addition of acid of the compounds of the formula (I), characterized in that (a) is condensed, at a temperature in the range of 50 to 200º C and in the presence of a basic catalyst, a pyrimidine compound of the formula: ** (See formula) ** with an acetonitrile derivative of the formula ** (See formula) ** to form a pteridine compound of the formula: ** (See formula) ** in which X is the amide group (see formula); or X is a carboxylic acid radical or a derivative thereof, which is convertible to said amide group, and X has, then, the formula ** (See formula) ** wherein M is oxygen and Z is a halogen atom, or the remainder of an ester or anhydride, or the group (see formula) -halogen; or M is = NH and Z is an ether residue, wherein, in formulas (II), (III), (IV), and (V), n, Ar, R and R 'are as defined for the formula (I); and R2 and/or R3 are hydrogen or are R "and R '" as defined for formula (I), and if X is the radical (see formula) of the formula (V), can be formed after the condensation to form the pteridine of the formula (IV); and, then, the radical X is converted to the amide group. ** (See formula) ** by condensation with an amine of the formula ** (See formula) ** where R2 and R3 are as defined above and Y is a hydrogen atom or (see formula) and (b), if R2 and/or R3 are hydrogen, the product of operation (a) is alkylated to convert these into alkyl or hydroxyalkyl groups and (c) to form, if desired, salts by addition of acid from the previous one. (Machine-translation by Google Translate, not legally binding)
ES277369A 1961-05-16 1962-05-16 A procedure for preparing 2-aril-4,7-diamino-N-disubstituºdo-aminoalcohil-6-pteridincarboxamidas (Machine-translation by Google Translate, not legally binding) Expired ES277369A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11033961A 1961-05-16 1961-05-16

Publications (1)

Publication Number Publication Date
ES277369A1 true ES277369A1 (en) 1963-01-01

Family

ID=22332472

Family Applications (1)

Application Number Title Priority Date Filing Date
ES277369A Expired ES277369A1 (en) 1961-05-16 1962-05-16 A procedure for preparing 2-aril-4,7-diamino-N-disubstituºdo-aminoalcohil-6-pteridincarboxamidas (Machine-translation by Google Translate, not legally binding)

Country Status (4)

Country Link
BE (1) BE617715A (en)
ES (1) ES277369A1 (en)
FR (1) FR1995M (en)
GB (1) GB983118A (en)

Also Published As

Publication number Publication date
GB983118A (en) 1965-02-10
FR1995M (en) 1963-09-02
BE617715A (en) 1962-11-16

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