ES2995480T3 - Continuous diafiltration by means of tank cycling - Google Patents
Continuous diafiltration by means of tank cycling Download PDFInfo
- Publication number
- ES2995480T3 ES2995480T3 ES18804820T ES18804820T ES2995480T3 ES 2995480 T3 ES2995480 T3 ES 2995480T3 ES 18804820 T ES18804820 T ES 18804820T ES 18804820 T ES18804820 T ES 18804820T ES 2995480 T3 ES2995480 T3 ES 2995480T3
- Authority
- ES
- Spain
- Prior art keywords
- diafiltration
- cycling
- liquid sample
- tank
- batch
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000001351 cycling effect Effects 0.000 title claims abstract description 131
- 238000011035 continuous diafiltration Methods 0.000 title claims abstract description 78
- 238000000034 method Methods 0.000 claims abstract description 109
- 230000008569 process Effects 0.000 claims abstract description 90
- 238000001914 filtration Methods 0.000 claims abstract description 79
- 239000007788 liquid Substances 0.000 claims abstract description 63
- 239000012465 retentate Substances 0.000 claims abstract description 62
- 239000000047 product Substances 0.000 claims abstract description 43
- 238000011049 filling Methods 0.000 claims abstract description 20
- 238000011026 diafiltration Methods 0.000 claims description 166
- 239000012530 fluid Substances 0.000 claims description 33
- 238000009295 crossflow filtration Methods 0.000 claims description 26
- 238000011027 product recovery Methods 0.000 claims description 23
- 239000007853 buffer solution Substances 0.000 claims description 22
- 238000000429 assembly Methods 0.000 claims description 20
- 230000000712 assembly Effects 0.000 claims description 20
- 239000012466 permeate Substances 0.000 claims description 20
- 238000011080 single-pass tangential flow filtration Methods 0.000 claims description 17
- 238000004140 cleaning Methods 0.000 claims description 16
- 239000012538 diafiltration buffer Substances 0.000 claims description 10
- 238000004891 communication Methods 0.000 claims description 7
- 238000011144 upstream manufacturing Methods 0.000 claims description 7
- 238000005406 washing Methods 0.000 claims description 7
- 239000012467 final product Substances 0.000 claims description 2
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 239000000523 sample Substances 0.000 description 93
- 239000012528 membrane Substances 0.000 description 52
- 239000000872 buffer Substances 0.000 description 46
- 238000012545 processing Methods 0.000 description 15
- 235000018102 proteins Nutrition 0.000 description 14
- 108090000623 proteins and genes Proteins 0.000 description 14
- 102000004169 proteins and genes Human genes 0.000 description 14
- 238000011084 recovery Methods 0.000 description 13
- 230000008929 regeneration Effects 0.000 description 9
- 238000011069 regeneration method Methods 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- 238000000108 ultra-filtration Methods 0.000 description 8
- 238000001471 micro-filtration Methods 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 238000010977 unit operation Methods 0.000 description 5
- 230000008859 change Effects 0.000 description 4
- 238000010924 continuous production Methods 0.000 description 4
- 238000010790 dilution Methods 0.000 description 4
- 239000012895 dilution Substances 0.000 description 4
- 238000011010 flushing procedure Methods 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 230000000717 retained effect Effects 0.000 description 4
- 238000001223 reverse osmosis Methods 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000010923 batch production Methods 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 238000004587 chromatography analysis Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 238000001728 nano-filtration Methods 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 230000002441 reversible effect Effects 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 239000000611 antibody drug conjugate Substances 0.000 description 2
- 229940049595 antibody-drug conjugate Drugs 0.000 description 2
- 229960000074 biopharmaceutical Drugs 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 238000011217 control strategy Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000011067 equilibration Methods 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 239000012510 hollow fiber Substances 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 239000013627 low molecular weight specie Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000002953 phosphate buffered saline Substances 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000003134 recirculating effect Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 230000001960 triggered effect Effects 0.000 description 2
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 description 1
- 108010060123 Conjugate Vaccines Proteins 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 108091006006 PEGylated Proteins Proteins 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 150000001242 acetic acid derivatives Chemical class 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 238000011021 bench scale process Methods 0.000 description 1
- 238000010364 biochemical engineering Methods 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229940031670 conjugate vaccine Drugs 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 235000014304 histidine Nutrition 0.000 description 1
- 150000002411 histidines Chemical class 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 238000005339 levitation Methods 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000012805 post-processing Methods 0.000 description 1
- 238000007781 pre-processing Methods 0.000 description 1
- 238000011112 process operation Methods 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000012460 protein solution Substances 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000012419 revalidation Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000026676 system process Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 238000011100 viral filtration Methods 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/149—Multistep processes comprising different kinds of membrane processes selected from ultrafiltration or microfiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/18—Apparatus therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/22—Controlling or regulating
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
- B01D65/02—Membrane cleaning or sterilisation ; Membrane regeneration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/04—Specific process operations in the feed stream; Feed pretreatment
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/08—Specific process operations in the concentrate stream
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/12—Addition of chemical agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/25—Recirculation, recycling or bypass, e.g. recirculation of concentrate into the feed
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/25—Recirculation, recycling or bypass, e.g. recirculation of concentrate into the feed
- B01D2311/252—Recirculation of concentrate
- B01D2311/2523—Recirculation of concentrate to feed side
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2313/00—Details relating to membrane modules or apparatus
- B01D2313/18—Specific valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2313/00—Details relating to membrane modules or apparatus
- B01D2313/24—Specific pressurizing or depressurizing means
- B01D2313/243—Pumps
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2313/00—Details relating to membrane modules or apparatus
- B01D2313/48—Mechanisms for switching between regular separation operations and washing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2313/00—Details relating to membrane modules or apparatus
- B01D2313/50—Specific extra tanks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2313/00—Details relating to membrane modules or apparatus
- B01D2313/50—Specific extra tanks
- B01D2313/502—Concentrate storage tanks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2313/00—Details relating to membrane modules or apparatus
- B01D2313/60—Specific sensors or sensor arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2315/00—Details relating to the membrane module operation
- B01D2315/10—Cross-flow filtration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2315/00—Details relating to the membrane module operation
- B01D2315/14—Batch-systems
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2315/00—Details relating to the membrane module operation
- B01D2315/16—Diafiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2317/00—Membrane module arrangements within a plant or an apparatus
- B01D2317/02—Elements in series
- B01D2317/022—Reject series
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2317/00—Membrane module arrangements within a plant or an apparatus
- B01D2317/04—Elements in parallel
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
- B01D2321/04—Backflushing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
- B01D2321/16—Use of chemical agents
- B01D2321/168—Use of other chemical agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
- B01D2321/40—Automatic control of cleaning processes
Landscapes
- Engineering & Computer Science (AREA)
- Water Supply & Treatment (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762585132P | 2017-11-13 | 2017-11-13 | |
| PCT/US2018/058660 WO2019094249A1 (en) | 2017-11-13 | 2018-11-01 | Continuous diafiltration by means of tank cycling |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2995480T3 true ES2995480T3 (en) | 2025-02-10 |
Family
ID=64362696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES18804820T Active ES2995480T3 (en) | 2017-11-13 | 2018-11-01 | Continuous diafiltration by means of tank cycling |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11691107B2 (https=) |
| EP (1) | EP3710141B1 (https=) |
| JP (1) | JP7177154B2 (https=) |
| KR (2) | KR20220050232A (https=) |
| CN (1) | CN111246930B (https=) |
| CA (1) | CA3080724C (https=) |
| ES (1) | ES2995480T3 (https=) |
| SG (1) | SG11202001497PA (https=) |
| TW (2) | TWI753216B (https=) |
| WO (1) | WO2019094249A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111246930B (zh) | 2017-11-13 | 2022-12-02 | Emd密理博公司 | 通过罐循环的连续透滤 |
| ES3064507T3 (en) * | 2018-08-07 | 2026-04-27 | Merz Pharma Gmbh & Co Kgaa | Method for dynamic filtration of a cross-linked hydrogel |
| US11241656B2 (en) * | 2018-11-29 | 2022-02-08 | Watersep Bioseparations Llc | Single pass cross flow diafiltration module and method |
| EP3939691B1 (en) * | 2020-07-13 | 2023-11-22 | Sartorius Stedim Biotech GmbH | Device assembly for producing bioconjugates |
| EP4182427A1 (en) * | 2020-07-15 | 2023-05-24 | Global Life Sciences Solutions USA LLC | Bioprocessing perfusion system having a plurality of filters and method of operating the same |
| CN116406369A (zh) * | 2020-10-05 | 2023-07-07 | 百时美施贵宝公司 | 用于浓缩蛋白质的方法 |
| WO2022251261A1 (en) * | 2021-05-25 | 2022-12-01 | Boehringer Ingelheim International Gmbh | A method and system for integrated and continuous viral filtration, concentration and buffer exchange |
| WO2023183269A1 (en) * | 2022-03-21 | 2023-09-28 | Repligen Corporation | Variable pathlength uv spectroscopy based automated tff system |
| WO2023230492A1 (en) * | 2022-05-26 | 2023-11-30 | Eli Lilly And Company | Continuous tangential flow filtration system |
| WO2024138152A1 (en) * | 2022-12-23 | 2024-06-27 | Asahi Kasei Bioprocess America, Inc. | System for performing cleavage, deprotection, ultrafiltration, and diafiltration operations |
| IT202300017964A1 (it) * | 2023-08-31 | 2025-03-03 | Antoni Bellussi | Impianto di filtrazione di sostanze semisolide e liquide di vario genere e metodo di funzonamento di tale impianto |
| WO2025087829A1 (en) * | 2023-10-24 | 2025-05-01 | Merck Patent Gmbh | Continuous filtration by means of feed cycling |
| SE547261C2 (en) * | 2024-02-20 | 2025-06-17 | Helios Innovations AB | Method and system for managing process fluid |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5871652A (en) | 1995-08-04 | 1999-02-16 | Pipetronics, Inc. | Method for high volume pipeline water filtration |
| JP2000126767A (ja) * | 1998-10-21 | 2000-05-09 | Toray Ind Inc | 精製水の製造方法および装置 |
| US7384549B2 (en) * | 2005-12-29 | 2008-06-10 | Spf Innovations, Llc | Method and apparatus for the filtration of biological solutions |
| JP4805201B2 (ja) * | 2007-03-22 | 2011-11-02 | 月島環境エンジニアリング株式会社 | 膜分離を用いた目的物質の分離方法と装置 |
| US8147692B2 (en) * | 2008-01-04 | 2012-04-03 | Fluid Equipment Development Company, Llc | Batch-operated reverse osmosis system with multiple membranes in a pressure vessel |
| WO2010090864A2 (en) * | 2009-01-21 | 2010-08-12 | Smartflow Technologies, Inc. | Optimization of separation for viscous suspensions |
| EP2644259A1 (en) | 2012-03-29 | 2013-10-02 | Roche Diagniostics GmbH | Micro flow filtration system and flow filtration method |
| EP2682168A1 (en) * | 2012-07-02 | 2014-01-08 | Millipore Corporation | Purification of biological molecules |
| CN104583386A (zh) * | 2012-08-20 | 2015-04-29 | 泰尔茂比司特公司 | 浓缩穿过细胞生长腔室循环的流体的组分 |
| US9770804B2 (en) * | 2013-03-18 | 2017-09-26 | Versum Materials Us, Llc | Slurry supply and/or chemical blend supply apparatuses, processes, methods of use and methods of manufacture |
| US9821274B1 (en) * | 2014-02-09 | 2017-11-21 | Spf Innovations Llc | Hybrid diafiltration system and methods |
| EP3113865A4 (en) * | 2014-03-07 | 2017-11-01 | Agency For Science, Technology And Research | Apparatus and methods for fractionation of biological products |
| SG11201508664VA (en) | 2014-08-29 | 2016-03-30 | Emd Millipore Corp | Single Pass Tangential Flow Filtration Systems and Tangential Flow Filtration Systems withRecirculation of Retentate |
| CN111246930B (zh) | 2017-11-13 | 2022-12-02 | Emd密理博公司 | 通过罐循环的连续透滤 |
-
2018
- 2018-11-01 CN CN201880068067.5A patent/CN111246930B/zh active Active
- 2018-11-01 US US16/762,688 patent/US11691107B2/en active Active
- 2018-11-01 KR KR1020227011789A patent/KR20220050232A/ko not_active Ceased
- 2018-11-01 KR KR1020207013242A patent/KR102386215B1/ko active Active
- 2018-11-01 ES ES18804820T patent/ES2995480T3/es active Active
- 2018-11-01 WO PCT/US2018/058660 patent/WO2019094249A1/en not_active Ceased
- 2018-11-01 SG SG11202001497PA patent/SG11202001497PA/en unknown
- 2018-11-01 CA CA3080724A patent/CA3080724C/en active Active
- 2018-11-01 JP JP2020522302A patent/JP7177154B2/ja active Active
- 2018-11-01 EP EP18804820.1A patent/EP3710141B1/en active Active
- 2018-11-05 TW TW107139122A patent/TWI753216B/zh active
- 2018-11-05 TW TW111103761A patent/TWI788212B/zh active
-
2023
- 2023-03-14 US US18/183,609 patent/US12128359B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP7177154B2 (ja) | 2022-11-22 |
| CA3080724A1 (en) | 2019-05-16 |
| SG11202001497PA (en) | 2020-03-30 |
| TW202220708A (zh) | 2022-06-01 |
| KR20220050232A (ko) | 2022-04-22 |
| US12128359B2 (en) | 2024-10-29 |
| US20230211291A1 (en) | 2023-07-06 |
| KR20200060765A (ko) | 2020-06-01 |
| EP3710141B1 (en) | 2024-07-03 |
| WO2019094249A1 (en) | 2019-05-16 |
| CN111246930B (zh) | 2022-12-02 |
| CN111246930A (zh) | 2020-06-05 |
| EP3710141A1 (en) | 2020-09-23 |
| TWI753216B (zh) | 2022-01-21 |
| JP2021502232A (ja) | 2021-01-28 |
| KR102386215B1 (ko) | 2022-04-15 |
| CA3080724C (en) | 2023-04-25 |
| TWI788212B (zh) | 2022-12-21 |
| US20210170336A1 (en) | 2021-06-10 |
| US11691107B2 (en) | 2023-07-04 |
| TW201922305A (zh) | 2019-06-16 |
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| Publication | Publication Date | Title |
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