CA3080724C - Continuous diafiltration by means of tank cycling - Google Patents

Continuous diafiltration by means of tank cycling Download PDF

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Publication number
CA3080724C
CA3080724C CA3080724A CA3080724A CA3080724C CA 3080724 C CA3080724 C CA 3080724C CA 3080724 A CA3080724 A CA 3080724A CA 3080724 A CA3080724 A CA 3080724A CA 3080724 C CA3080724 C CA 3080724C
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CA
Canada
Prior art keywords
diafiltration
cycling
liquid sample
tank
assembly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3080724A
Other languages
English (en)
French (fr)
Other versions
CA3080724A1 (en
Inventor
Elizabeth M. Goodrich
Akshat GUPTA
Herbert Lutz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EMD Millipore Corp
Original Assignee
EMD Millipore Corp
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Filing date
Publication date
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Publication of CA3080724A1 publication Critical patent/CA3080724A1/en
Application granted granted Critical
Publication of CA3080724C publication Critical patent/CA3080724C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/149—Multistep processes comprising different kinds of membrane processes selected from ultrafiltration or microfiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/18—Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/22—Controlling or regulating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
    • B01D65/02—Membrane cleaning or sterilisation ; Membrane regeneration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/04—Specific process operations in the feed stream; Feed pretreatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/08—Specific process operations in the concentrate stream
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/12—Addition of chemical agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/25—Recirculation, recycling or bypass, e.g. recirculation of concentrate into the feed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/25—Recirculation, recycling or bypass, e.g. recirculation of concentrate into the feed
    • B01D2311/252—Recirculation of concentrate
    • B01D2311/2523—Recirculation of concentrate to feed side
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/18—Specific valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/24—Specific pressurizing or depressurizing means
    • B01D2313/243—Pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/48—Mechanisms for switching between regular separation operations and washing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/50—Specific extra tanks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/50—Specific extra tanks
    • B01D2313/502—Concentrate storage tanks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/60—Specific sensors or sensor arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/10—Cross-flow filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/14—Batch-systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/16—Diafiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2317/00—Membrane module arrangements within a plant or an apparatus
    • B01D2317/02—Elements in series
    • B01D2317/022—Reject series
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2317/00—Membrane module arrangements within a plant or an apparatus
    • B01D2317/04—Elements in parallel
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/04—Backflushing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/16—Use of chemical agents
    • B01D2321/168—Use of other chemical agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/40—Automatic control of cleaning processes

Landscapes

  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA3080724A 2017-11-13 2018-11-01 Continuous diafiltration by means of tank cycling Active CA3080724C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762585132P 2017-11-13 2017-11-13
US62/585,132 2017-11-13
PCT/US2018/058660 WO2019094249A1 (en) 2017-11-13 2018-11-01 Continuous diafiltration by means of tank cycling

Publications (2)

Publication Number Publication Date
CA3080724A1 CA3080724A1 (en) 2019-05-16
CA3080724C true CA3080724C (en) 2023-04-25

Family

ID=64362696

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3080724A Active CA3080724C (en) 2017-11-13 2018-11-01 Continuous diafiltration by means of tank cycling

Country Status (10)

Country Link
US (2) US11691107B2 (https=)
EP (1) EP3710141B1 (https=)
JP (1) JP7177154B2 (https=)
KR (2) KR20220050232A (https=)
CN (1) CN111246930B (https=)
CA (1) CA3080724C (https=)
ES (1) ES2995480T3 (https=)
SG (1) SG11202001497PA (https=)
TW (2) TWI753216B (https=)
WO (1) WO2019094249A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111246930B (zh) 2017-11-13 2022-12-02 Emd密理博公司 通过罐循环的连续透滤
ES3064507T3 (en) * 2018-08-07 2026-04-27 Merz Pharma Gmbh & Co Kgaa Method for dynamic filtration of a cross-linked hydrogel
US11241656B2 (en) * 2018-11-29 2022-02-08 Watersep Bioseparations Llc Single pass cross flow diafiltration module and method
EP3939691B1 (en) * 2020-07-13 2023-11-22 Sartorius Stedim Biotech GmbH Device assembly for producing bioconjugates
EP4182427A1 (en) * 2020-07-15 2023-05-24 Global Life Sciences Solutions USA LLC Bioprocessing perfusion system having a plurality of filters and method of operating the same
CN116406369A (zh) * 2020-10-05 2023-07-07 百时美施贵宝公司 用于浓缩蛋白质的方法
WO2022251261A1 (en) * 2021-05-25 2022-12-01 Boehringer Ingelheim International Gmbh A method and system for integrated and continuous viral filtration, concentration and buffer exchange
WO2023183269A1 (en) * 2022-03-21 2023-09-28 Repligen Corporation Variable pathlength uv spectroscopy based automated tff system
WO2023230492A1 (en) * 2022-05-26 2023-11-30 Eli Lilly And Company Continuous tangential flow filtration system
WO2024138152A1 (en) * 2022-12-23 2024-06-27 Asahi Kasei Bioprocess America, Inc. System for performing cleavage, deprotection, ultrafiltration, and diafiltration operations
IT202300017964A1 (it) * 2023-08-31 2025-03-03 Antoni Bellussi Impianto di filtrazione di sostanze semisolide e liquide di vario genere e metodo di funzonamento di tale impianto
WO2025087829A1 (en) * 2023-10-24 2025-05-01 Merck Patent Gmbh Continuous filtration by means of feed cycling
SE547261C2 (en) * 2024-02-20 2025-06-17 Helios Innovations AB Method and system for managing process fluid

Family Cites Families (14)

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Publication number Priority date Publication date Assignee Title
US5871652A (en) 1995-08-04 1999-02-16 Pipetronics, Inc. Method for high volume pipeline water filtration
JP2000126767A (ja) * 1998-10-21 2000-05-09 Toray Ind Inc 精製水の製造方法および装置
US7384549B2 (en) * 2005-12-29 2008-06-10 Spf Innovations, Llc Method and apparatus for the filtration of biological solutions
JP4805201B2 (ja) * 2007-03-22 2011-11-02 月島環境エンジニアリング株式会社 膜分離を用いた目的物質の分離方法と装置
US8147692B2 (en) * 2008-01-04 2012-04-03 Fluid Equipment Development Company, Llc Batch-operated reverse osmosis system with multiple membranes in a pressure vessel
WO2010090864A2 (en) * 2009-01-21 2010-08-12 Smartflow Technologies, Inc. Optimization of separation for viscous suspensions
EP2644259A1 (en) 2012-03-29 2013-10-02 Roche Diagniostics GmbH Micro flow filtration system and flow filtration method
EP2682168A1 (en) * 2012-07-02 2014-01-08 Millipore Corporation Purification of biological molecules
CN104583386A (zh) * 2012-08-20 2015-04-29 泰尔茂比司特公司 浓缩穿过细胞生长腔室循环的流体的组分
US9770804B2 (en) * 2013-03-18 2017-09-26 Versum Materials Us, Llc Slurry supply and/or chemical blend supply apparatuses, processes, methods of use and methods of manufacture
US9821274B1 (en) * 2014-02-09 2017-11-21 Spf Innovations Llc Hybrid diafiltration system and methods
EP3113865A4 (en) * 2014-03-07 2017-11-01 Agency For Science, Technology And Research Apparatus and methods for fractionation of biological products
SG11201508664VA (en) 2014-08-29 2016-03-30 Emd Millipore Corp Single Pass Tangential Flow Filtration Systems and Tangential Flow Filtration Systems withRecirculation of Retentate
CN111246930B (zh) 2017-11-13 2022-12-02 Emd密理博公司 通过罐循环的连续透滤

Also Published As

Publication number Publication date
JP7177154B2 (ja) 2022-11-22
CA3080724A1 (en) 2019-05-16
SG11202001497PA (en) 2020-03-30
TW202220708A (zh) 2022-06-01
KR20220050232A (ko) 2022-04-22
US12128359B2 (en) 2024-10-29
ES2995480T3 (en) 2025-02-10
US20230211291A1 (en) 2023-07-06
KR20200060765A (ko) 2020-06-01
EP3710141B1 (en) 2024-07-03
WO2019094249A1 (en) 2019-05-16
CN111246930B (zh) 2022-12-02
CN111246930A (zh) 2020-06-05
EP3710141A1 (en) 2020-09-23
TWI753216B (zh) 2022-01-21
JP2021502232A (ja) 2021-01-28
KR102386215B1 (ko) 2022-04-15
TWI788212B (zh) 2022-12-21
US20210170336A1 (en) 2021-06-10
US11691107B2 (en) 2023-07-04
TW201922305A (zh) 2019-06-16

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