CN111246930B - 通过罐循环的连续透滤 - Google Patents

通过罐循环的连续透滤 Download PDF

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Publication number
CN111246930B
CN111246930B CN201880068067.5A CN201880068067A CN111246930B CN 111246930 B CN111246930 B CN 111246930B CN 201880068067 A CN201880068067 A CN 201880068067A CN 111246930 B CN111246930 B CN 111246930B
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China
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diafiltration
liquid sample
tank
batch
retentate
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CN201880068067.5A
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English (en)
Chinese (zh)
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CN111246930A (zh
Inventor
E·M·古德里奇
A·古普塔
H·卢茨
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EMD Millipore Corp
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EMD Millipore Corp
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/149—Multistep processes comprising different kinds of membrane processes selected from ultrafiltration or microfiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/18—Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/22—Controlling or regulating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
    • B01D65/02—Membrane cleaning or sterilisation ; Membrane regeneration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/04—Specific process operations in the feed stream; Feed pretreatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/08—Specific process operations in the concentrate stream
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/12—Addition of chemical agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/25—Recirculation, recycling or bypass, e.g. recirculation of concentrate into the feed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/25—Recirculation, recycling or bypass, e.g. recirculation of concentrate into the feed
    • B01D2311/252—Recirculation of concentrate
    • B01D2311/2523—Recirculation of concentrate to feed side
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/18—Specific valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/24—Specific pressurizing or depressurizing means
    • B01D2313/243—Pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/48—Mechanisms for switching between regular separation operations and washing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/50—Specific extra tanks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/50—Specific extra tanks
    • B01D2313/502—Concentrate storage tanks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/60—Specific sensors or sensor arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/10—Cross-flow filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/14—Batch-systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/16—Diafiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2317/00—Membrane module arrangements within a plant or an apparatus
    • B01D2317/02—Elements in series
    • B01D2317/022—Reject series
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2317/00—Membrane module arrangements within a plant or an apparatus
    • B01D2317/04—Elements in parallel
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/04—Backflushing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/16—Use of chemical agents
    • B01D2321/168—Use of other chemical agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/40—Automatic control of cleaning processes

Landscapes

  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201880068067.5A 2017-11-13 2018-11-01 通过罐循环的连续透滤 Active CN111246930B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762585132P 2017-11-13 2017-11-13
US62/585,132 2017-11-13
PCT/US2018/058660 WO2019094249A1 (en) 2017-11-13 2018-11-01 Continuous diafiltration by means of tank cycling

Publications (2)

Publication Number Publication Date
CN111246930A CN111246930A (zh) 2020-06-05
CN111246930B true CN111246930B (zh) 2022-12-02

Family

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CN201880068067.5A Active CN111246930B (zh) 2017-11-13 2018-11-01 通过罐循环的连续透滤

Country Status (10)

Country Link
US (2) US11691107B2 (https=)
EP (1) EP3710141B1 (https=)
JP (1) JP7177154B2 (https=)
KR (2) KR20220050232A (https=)
CN (1) CN111246930B (https=)
CA (1) CA3080724C (https=)
ES (1) ES2995480T3 (https=)
SG (1) SG11202001497PA (https=)
TW (2) TWI753216B (https=)
WO (1) WO2019094249A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111246930B (zh) 2017-11-13 2022-12-02 Emd密理博公司 通过罐循环的连续透滤
ES3064507T3 (en) * 2018-08-07 2026-04-27 Merz Pharma Gmbh & Co Kgaa Method for dynamic filtration of a cross-linked hydrogel
US11241656B2 (en) * 2018-11-29 2022-02-08 Watersep Bioseparations Llc Single pass cross flow diafiltration module and method
EP3939691B1 (en) * 2020-07-13 2023-11-22 Sartorius Stedim Biotech GmbH Device assembly for producing bioconjugates
EP4182427A1 (en) * 2020-07-15 2023-05-24 Global Life Sciences Solutions USA LLC Bioprocessing perfusion system having a plurality of filters and method of operating the same
CN116406369A (zh) * 2020-10-05 2023-07-07 百时美施贵宝公司 用于浓缩蛋白质的方法
WO2022251261A1 (en) * 2021-05-25 2022-12-01 Boehringer Ingelheim International Gmbh A method and system for integrated and continuous viral filtration, concentration and buffer exchange
WO2023183269A1 (en) * 2022-03-21 2023-09-28 Repligen Corporation Variable pathlength uv spectroscopy based automated tff system
WO2023230492A1 (en) * 2022-05-26 2023-11-30 Eli Lilly And Company Continuous tangential flow filtration system
WO2024138152A1 (en) * 2022-12-23 2024-06-27 Asahi Kasei Bioprocess America, Inc. System for performing cleavage, deprotection, ultrafiltration, and diafiltration operations
IT202300017964A1 (it) * 2023-08-31 2025-03-03 Antoni Bellussi Impianto di filtrazione di sostanze semisolide e liquide di vario genere e metodo di funzonamento di tale impianto
WO2025087829A1 (en) * 2023-10-24 2025-05-01 Merck Patent Gmbh Continuous filtration by means of feed cycling
SE547261C2 (en) * 2024-02-20 2025-06-17 Helios Innovations AB Method and system for managing process fluid

Citations (3)

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JP2000126767A (ja) * 1998-10-21 2000-05-09 Toray Ind Inc 精製水の製造方法および装置
CN101547735A (zh) * 2007-03-22 2009-09-30 月岛环境工程株式会社 使用膜分离的目标物质的分离方法和装置
CN104220149A (zh) * 2012-03-29 2014-12-17 弗·哈夫曼-拉罗切有限公司 微流过滤系统和流过滤方法

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US5871652A (en) 1995-08-04 1999-02-16 Pipetronics, Inc. Method for high volume pipeline water filtration
US7384549B2 (en) * 2005-12-29 2008-06-10 Spf Innovations, Llc Method and apparatus for the filtration of biological solutions
US8147692B2 (en) * 2008-01-04 2012-04-03 Fluid Equipment Development Company, Llc Batch-operated reverse osmosis system with multiple membranes in a pressure vessel
WO2010090864A2 (en) * 2009-01-21 2010-08-12 Smartflow Technologies, Inc. Optimization of separation for viscous suspensions
EP2682168A1 (en) * 2012-07-02 2014-01-08 Millipore Corporation Purification of biological molecules
CN104583386A (zh) * 2012-08-20 2015-04-29 泰尔茂比司特公司 浓缩穿过细胞生长腔室循环的流体的组分
US9770804B2 (en) * 2013-03-18 2017-09-26 Versum Materials Us, Llc Slurry supply and/or chemical blend supply apparatuses, processes, methods of use and methods of manufacture
US9821274B1 (en) * 2014-02-09 2017-11-21 Spf Innovations Llc Hybrid diafiltration system and methods
EP3113865A4 (en) * 2014-03-07 2017-11-01 Agency For Science, Technology And Research Apparatus and methods for fractionation of biological products
SG11201508664VA (en) 2014-08-29 2016-03-30 Emd Millipore Corp Single Pass Tangential Flow Filtration Systems and Tangential Flow Filtration Systems withRecirculation of Retentate
CN111246930B (zh) 2017-11-13 2022-12-02 Emd密理博公司 通过罐循环的连续透滤

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000126767A (ja) * 1998-10-21 2000-05-09 Toray Ind Inc 精製水の製造方法および装置
CN101547735A (zh) * 2007-03-22 2009-09-30 月岛环境工程株式会社 使用膜分离的目标物质的分离方法和装置
CN104220149A (zh) * 2012-03-29 2014-12-17 弗·哈夫曼-拉罗切有限公司 微流过滤系统和流过滤方法

Also Published As

Publication number Publication date
JP7177154B2 (ja) 2022-11-22
CA3080724A1 (en) 2019-05-16
SG11202001497PA (en) 2020-03-30
TW202220708A (zh) 2022-06-01
KR20220050232A (ko) 2022-04-22
US12128359B2 (en) 2024-10-29
ES2995480T3 (en) 2025-02-10
US20230211291A1 (en) 2023-07-06
KR20200060765A (ko) 2020-06-01
EP3710141B1 (en) 2024-07-03
WO2019094249A1 (en) 2019-05-16
CN111246930A (zh) 2020-06-05
EP3710141A1 (en) 2020-09-23
TWI753216B (zh) 2022-01-21
JP2021502232A (ja) 2021-01-28
KR102386215B1 (ko) 2022-04-15
CA3080724C (en) 2023-04-25
TWI788212B (zh) 2022-12-21
US20210170336A1 (en) 2021-06-10
US11691107B2 (en) 2023-07-04
TW201922305A (zh) 2019-06-16

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