ES2987577T3 - Terlipresina para el tratamiento del síndrome hepatorrenal tipo 1 - Google Patents

Terlipresina para el tratamiento del síndrome hepatorrenal tipo 1 Download PDF

Info

Publication number
ES2987577T3
ES2987577T3 ES21205752T ES21205752T ES2987577T3 ES 2987577 T3 ES2987577 T3 ES 2987577T3 ES 21205752 T ES21205752 T ES 21205752T ES 21205752 T ES21205752 T ES 21205752T ES 2987577 T3 ES2987577 T3 ES 2987577T3
Authority
ES
Spain
Prior art keywords
patient
terlipressin
treatment
serum creatinine
hrs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES21205752T
Other languages
English (en)
Spanish (es)
Inventor
Khurram Jamil
Stephen Chris Pappas
Jim Potenziano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Pharmaceuticals Ireland Ltd
Original Assignee
Mallinckrodt Pharmaceuticals Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Pharmaceuticals Ireland Ltd filed Critical Mallinckrodt Pharmaceuticals Ireland Ltd
Application granted granted Critical
Publication of ES2987577T3 publication Critical patent/ES2987577T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/0205Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/024Measuring pulse rate or heart rate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14542Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring blood gases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • A61K38/095Oxytocins; Vasopressins; Related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38Albumins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M27/00Drainage appliance for wounds or the like, i.e. wound drains, implanted drains
    • A61M27/002Implant devices for drainage of body fluids from one part of the body to another
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/10Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/49Blood
    • G01N33/4925Blood measuring blood gas content, e.g. O2, CO2, HCO3
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/016White blood cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N2015/1024Counting particles by non-optical means

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Surgery (AREA)
  • Physiology (AREA)
  • Medical Informatics (AREA)
  • Ecology (AREA)
  • Food Science & Technology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Dispersion Chemistry (AREA)
  • Zoology (AREA)
ES21205752T 2014-10-24 2015-10-22 Terlipresina para el tratamiento del síndrome hepatorrenal tipo 1 Active ES2987577T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462068357P 2014-10-24 2014-10-24
US201562151384P 2015-04-22 2015-04-22

Publications (1)

Publication Number Publication Date
ES2987577T3 true ES2987577T3 (es) 2024-11-15

Family

ID=54478246

Family Applications (2)

Application Number Title Priority Date Filing Date
ES21205752T Active ES2987577T3 (es) 2014-10-24 2015-10-22 Terlipresina para el tratamiento del síndrome hepatorrenal tipo 1
ES15791430T Active ES2904492T3 (es) 2014-10-24 2015-10-22 Terlipresina para el tratamiento del síndrome hepatorrenal tipo 1

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES15791430T Active ES2904492T3 (es) 2014-10-24 2015-10-22 Terlipresina para el tratamiento del síndrome hepatorrenal tipo 1

Country Status (15)

Country Link
US (2) US10335452B2 (OSRAM)
EP (3) EP3978074B1 (OSRAM)
JP (4) JP6673915B2 (OSRAM)
CN (2) CN114028536B (OSRAM)
AU (1) AU2015335855A1 (OSRAM)
CA (1) CA2965325A1 (OSRAM)
DK (2) DK3978074T3 (OSRAM)
ES (2) ES2987577T3 (OSRAM)
FI (1) FI3978074T3 (OSRAM)
HR (1) HRP20220225T1 (OSRAM)
HU (1) HUE058066T2 (OSRAM)
PL (2) PL3209317T3 (OSRAM)
PT (2) PT3209317T (OSRAM)
SI (1) SI3209317T1 (OSRAM)
WO (1) WO2016065117A1 (OSRAM)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5623406B2 (ja) 2008-09-17 2014-11-12 キアズマ インコーポレイテッド 医薬組成物および関連する送達方法
US20200046798A1 (en) * 2014-10-24 2020-02-13 Mallinckrodt Hospital Products IP Limited Method of treating patients with hepatorenal syndrome type 1
US20210290725A1 (en) * 2014-10-24 2021-09-23 Mallinckrodt Pharmaceuticals Ireland Limited Method of treating patients with hepatorenal syndrome type 1
EP3978074B1 (en) * 2014-10-24 2024-03-06 Mallinckrodt Pharmaceuticals Ireland Limited Terlipressin for treating hepatorenal syndrome type 1
CA3037581A1 (en) 2016-10-21 2018-04-26 Chiasma, Inc. Terlipressin compositions and their methods of use
CN114096267B (zh) 2019-05-22 2025-03-18 柏欧韦股份有限公司 特利加压素制剂
CN110251469B (zh) * 2019-07-31 2021-11-09 南京康舟医药科技有限公司 一种醋酸特利加压素制剂及其制备方法
BR112022006329A2 (pt) * 2019-10-30 2022-08-16 Mallinckrodt Hospital Products IP Unlimited Company Método de tratamento de pacientes com síndrome hepatorrenal tipo 1 e pressão arterial média baixa
WO2023183339A1 (en) * 2022-03-22 2023-09-28 Ocelot Bio, Inc. Selective vasopressin receptor agonist for end-stage liver disease
US20240156895A1 (en) * 2022-10-28 2024-05-16 Mallinckrodt Pharmaceuticals Ireland Limited Compositions for improving kidney function in patients with hepatorenal syndrome

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1188443A1 (en) 2000-09-15 2002-03-20 Ferring BV Improved protocol for paracentesis
US7785857B2 (en) * 2006-08-31 2010-08-31 Saint Louis University Protein C variant
GB0617581D0 (en) * 2006-09-07 2006-10-18 Ucl Business Plc Biomarkers for assessing liver function
US20080221551A1 (en) * 2007-03-09 2008-09-11 Flowmedica, Inc. Acute kidney injury treatment systems and methods
WO2009037586A2 (en) 2007-08-14 2009-03-26 Ferring B.V. Use of peptidic vasopressin receptor agonists
EP2913676A1 (en) * 2008-11-10 2015-09-02 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
KR20110136825A (ko) 2009-03-09 2011-12-21 바이오아트라, 엘엘씨 미락 단백질
EP2799067B1 (en) 2009-06-08 2019-04-03 UCL Business PLC Treatment of brain inflammation using L-Ornithine Phenylacetate
EP2593541A4 (en) * 2010-07-14 2014-01-22 Cumberland Emerging Technologies Inc METHOD FOR THE TREATMENT OF HEPATORENAL SYNDROME AND HEPATIC ENZEPHALOPATHY WITH THROMBOXANE A2 RECEPTOR ANTAGONISTS
JP2012159356A (ja) * 2011-01-31 2012-08-23 Mochida Pharmaceut Co Ltd 敗血症診断用組合せマーカー
CN103254295A (zh) * 2013-05-31 2013-08-21 青岛国大生物制药股份有限公司 特利加压素的制备方法
EP3978074B1 (en) * 2014-10-24 2024-03-06 Mallinckrodt Pharmaceuticals Ireland Limited Terlipressin for treating hepatorenal syndrome type 1
JP2017014206A (ja) 2015-06-30 2017-01-19 ナノアンティバイオティクス,インコーポレイテッド 腹水の治療

Also Published As

Publication number Publication date
JP2019199485A (ja) 2019-11-21
CN114028536B (zh) 2024-07-09
PT3978074T (pt) 2024-05-13
PL3209317T3 (pl) 2022-05-23
CN107206049B (zh) 2021-12-07
PL3978074T3 (pl) 2024-08-12
US20190328831A1 (en) 2019-10-31
JP2017534618A (ja) 2017-11-24
CA2965325A1 (en) 2016-04-28
EP3978074A1 (en) 2022-04-06
AU2015335855A1 (en) 2017-05-18
DK3978074T3 (da) 2024-05-13
CN114028536A (zh) 2022-02-11
EP3209317B1 (en) 2021-12-08
EP3209317A1 (en) 2017-08-30
JP2022171795A (ja) 2022-11-11
US20160113994A1 (en) 2016-04-28
US10335452B2 (en) 2019-07-02
JP6989571B2 (ja) 2022-01-05
HUE058066T2 (hu) 2022-06-28
DK3209317T3 (da) 2022-02-07
PT3209317T (pt) 2022-01-19
EP3981420A1 (en) 2022-04-13
JP2021155433A (ja) 2021-10-07
EP3978074B1 (en) 2024-03-06
HRP20220225T1 (hr) 2022-04-29
CN107206049A (zh) 2017-09-26
SI3209317T1 (sl) 2022-05-31
JP6673915B2 (ja) 2020-03-25
JP7346494B2 (ja) 2023-09-19
WO2016065117A1 (en) 2016-04-28
ES2904492T3 (es) 2022-04-05
FI3978074T3 (fi) 2024-05-20

Similar Documents

Publication Publication Date Title
ES2987577T3 (es) Terlipresina para el tratamiento del síndrome hepatorrenal tipo 1
ES2906865T3 (es) Uso de sulfatos de colesterol oxigenados (OCS) para tratar la insuficiencia hepática aguda
ES2941640T3 (es) Moduladores de la actividad del complemento
US20240374675A1 (en) Method of treating patients with hepatorenal syndrome type 1
US20220143132A1 (en) Method of treating patients with hepatorenal syndrome type 1
US20250276033A1 (en) Compositions for improving kidney function in patients with hepatorenal syndrome
ES2942441T3 (es) L-triyodotironina (T3) para el uso en la limitación de la obstrucción microvascular
US20200237856A1 (en) Method of treating patients with hepatorenal syndrome type 1
WO2022261102A1 (en) Method of treating patients with hepatorenal syndrome type 1