ES2985805T3 - Ligandos de formación de imágenes de TAU y sus usos en el diagnóstico y el tratamiento de tauopatías - Google Patents
Ligandos de formación de imágenes de TAU y sus usos en el diagnóstico y el tratamiento de tauopatías Download PDFInfo
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- ES2985805T3 ES2985805T3 ES15818480T ES15818480T ES2985805T3 ES 2985805 T3 ES2985805 T3 ES 2985805T3 ES 15818480 T ES15818480 T ES 15818480T ES 15818480 T ES15818480 T ES 15818480T ES 2985805 T3 ES2985805 T3 ES 2985805T3
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
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- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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- C07—ORGANIC CHEMISTRY
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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| US201462021897P | 2014-07-08 | 2014-07-08 | |
| PCT/US2015/039205 WO2016007414A1 (en) | 2014-07-08 | 2015-07-06 | Tau imaging ligands and their uses in the diagnosis and treatment of tauopathy |
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| JO3711B1 (ar) | 2015-07-13 | 2021-01-31 | H Lundbeck As | أجسام مضادة محددة لبروتين تاو وطرق استعمالها |
| CN108137679B (zh) * | 2015-08-13 | 2022-07-19 | 纽约大学 | 对Tau的{p}Ser404表位有选择性的基于抗体的分子和它们在诊断和治疗Tau疾病中的用途 |
| CN108135986B (zh) | 2015-08-13 | 2022-07-29 | 纽约大学 | 对于Tau的截短的Asp421表位特异性的基于抗体的分子和它们在诊断和治疗Tau疾病中的用途 |
| GEP20217222B (en) | 2016-07-12 | 2021-02-10 | Lundbeck A/S H | Antibodies specific for hyperphosphorylated tau and methods of use thereof |
| WO2018049219A1 (en) * | 2016-09-08 | 2018-03-15 | Regenerative Research Foundation | Bi-functional anti-tau polypeptides and use thereof |
| US10364286B2 (en) * | 2016-12-22 | 2019-07-30 | H. Lundbeck A/S | Monoclonal anti-alpha-synuclein antibodies for preventing tau aggregation |
| WO2018127519A1 (en) * | 2017-01-04 | 2018-07-12 | H. Lundbeck A/S | Antibodies specific for hyperphosphorylated tau for the treatment of ocular diseases |
| MA47499A (fr) | 2017-02-17 | 2019-12-25 | Denali Therapeutics Inc | Anticorps anti-tau et leurs procédés d'utilisation |
| JP7368856B2 (ja) | 2017-07-25 | 2023-10-25 | トゥルーバインディング，インコーポレイテッド | Ｔｉｍ－３とそのリガンドとの相互作用の遮断によるがん治療 |
| CN109406469B (zh) * | 2018-10-24 | 2021-04-09 | 中国医科大学 | 基于蛋白结合诱导dna双链变构的检测色氨酸的方法 |
| WO2020123492A1 (en) * | 2018-12-10 | 2020-06-18 | New York University | Monoclonal antibodies targeting c-terminal region of phosphorylated tau |
| CN116063505B (zh) | 2019-01-30 | 2024-05-03 | 真和制药有限公司 | 抗gal3抗体及其用途 |
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| EP4034240A4 (en) * | 2019-09-23 | 2023-11-15 | Macquarie University | TREATMENT OF TAUOPATHIES |
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| MXPA05000511A (es) | 2001-07-12 | 2005-09-30 | Jefferson Foote | Anticuepros super humanizados. |
| WO2006121656A2 (en) | 2005-05-05 | 2006-11-16 | Merck & Co., Inc. | Peptide conjugate compositions and methods for the prevention and treatment of alzheimer's disease |
| KR101866623B1 (ko) | 2005-11-28 | 2018-07-04 | 젠맵 에이/에스 | 재조합 １가 항체 및 그의 제조 방법 |
| US8012936B2 (en) | 2006-03-29 | 2011-09-06 | New York University | Tau fragments for immunotherapy |
| US20080220449A1 (en) | 2007-02-08 | 2008-09-11 | Oligomerix, Inc. | Biomarkers and assays for Alzheimer's disease |
| PT2408807T (pt) | 2009-03-18 | 2021-09-03 | Ac Immune Sa | Processo para utilização terapêutica |
| UA107571C2 (xx) | 2009-04-03 | 2015-01-26 | Фармацевтична композиція | |
| US8748386B2 (en) * | 2009-06-10 | 2014-06-10 | New York University | Immunological targeting of pathological Tau proteins |
| RU2518291C2 (ru) | 2009-07-30 | 2014-06-10 | Пфайзер Вэксинс ЭлЭлСи | Антигенные tau-пептиды и их применения |
| BR112014008202B1 (pt) * | 2011-10-07 | 2022-01-04 | Ac Immune S.A. | Anticorpo, polinucleotídeo, composição farmacêutica, usos de um anticorpo, método in vitro, método de detecção da formação de um complexo imunológico, método de detecção postmortem de multimêros do fosfo-tau, kits de teste, linhagem celular isolada e método de detecção de multimêros de fosfo-tau |
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2015
- 2015-07-06 WO PCT/US2015/039205 patent/WO2016007414A1/en not_active Ceased
- 2015-07-06 JP JP2017500891A patent/JP6913018B2/ja active Active
- 2015-07-06 CN CN201580047108.9A patent/CN107073297B/zh active Active
- 2015-07-06 ES ES15818480T patent/ES2985805T3/es active Active
- 2015-07-06 EP EP15818480.4A patent/EP3166688B1/en active Active
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2018
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2020
- 2020-10-19 US US17/073,871 patent/US11519920B2/en active Active
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|---|---|
| EP3166688A1 (en) | 2017-05-17 |
| US20210055309A1 (en) | 2021-02-25 |
| US11519920B2 (en) | 2022-12-06 |
| US20190025331A1 (en) | 2019-01-24 |
| CN107073297A (zh) | 2017-08-18 |
| EP3166688C0 (en) | 2024-08-21 |
| WO2016007414A1 (en) | 2016-01-14 |
| JP2017532288A (ja) | 2017-11-02 |
| JP6913018B2 (ja) | 2021-08-04 |
| US20170212131A1 (en) | 2017-07-27 |
| US10859582B2 (en) | 2020-12-08 |
| CN107073297B (zh) | 2021-09-14 |
| US10132818B2 (en) | 2018-11-20 |
| EP3166688A4 (en) | 2017-12-20 |
| EP3166688B1 (en) | 2024-08-21 |
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