ES2984281T3 - Composiciones que comprenden un antagonista de la aldosterona para su uso en el tratamiento de ojos secos - Google Patents
Composiciones que comprenden un antagonista de la aldosterona para su uso en el tratamiento de ojos secos Download PDFInfo
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- ES2984281T3 ES2984281T3 ES16759492T ES16759492T ES2984281T3 ES 2984281 T3 ES2984281 T3 ES 2984281T3 ES 16759492 T ES16759492 T ES 16759492T ES 16759492 T ES16759492 T ES 16759492T ES 2984281 T3 ES2984281 T3 ES 2984281T3
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- spironolactone
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- LQCLVBQBTUVCEQ-QTFUVMRISA-N troleandomycin Chemical compound O1[C@@H](C)[C@H](OC(C)=O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](OC(C)=O)[C@@H](C)C(=O)[C@@]2(OC2)C[C@H](C)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)OC(C)=O)[C@H]1C LQCLVBQBTUVCEQ-QTFUVMRISA-N 0.000 description 1
- UCCJWNPWWPJKGL-UHFFFAOYSA-N tropesin Chemical compound CC1=C(CC(=O)OCC(C(O)=O)C=2C=CC=CC=2)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 UCCJWNPWWPJKGL-UHFFFAOYSA-N 0.000 description 1
- 229950002470 tropesin Drugs 0.000 description 1
- 229960000497 trovafloxacin Drugs 0.000 description 1
- WVPSKSLAZQPAKQ-CDMJZVDBSA-N trovafloxacin Chemical compound C([C@H]1[C@@H]([C@H]1C1)N)N1C(C(=CC=1C(=O)C(C(O)=O)=C2)F)=NC=1N2C1=CC=C(F)C=C1F WVPSKSLAZQPAKQ-CDMJZVDBSA-N 0.000 description 1
- 229950008396 ulobetasol propionate Drugs 0.000 description 1
- BDSYKGHYMJNPAB-LICBFIPMSA-N ulobetasol propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H](C)[C@@](C(=O)CCl)(OC(=O)CC)[C@@]2(C)C[C@@H]1O BDSYKGHYMJNPAB-LICBFIPMSA-N 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 description 1
- 229960001661 ursodiol Drugs 0.000 description 1
- 210000001745 uvea Anatomy 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000004563 wettable powder Substances 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
- 229950000707 ximoprofen Drugs 0.000 description 1
- MTZBBNMLMNBNJL-UHFFFAOYSA-N xipamide Chemical compound CC1=CC=CC(C)=C1NC(=O)C1=CC(S(N)(=O)=O)=C(Cl)C=C1O MTZBBNMLMNBNJL-UHFFFAOYSA-N 0.000 description 1
- 229950004227 zaltoprofen Drugs 0.000 description 1
- 229960003414 zomepirac Drugs 0.000 description 1
- ZXVNMYWKKDOREA-UHFFFAOYSA-N zomepirac Chemical compound C1=C(CC(O)=O)N(C)C(C(=O)C=2C=CC(Cl)=CC=2)=C1C ZXVNMYWKKDOREA-UHFFFAOYSA-N 0.000 description 1
- 239000002888 zwitterionic surfactant Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562127362P | 2015-03-03 | 2015-03-03 | |
| PCT/US2016/020683 WO2016141182A1 (en) | 2015-03-03 | 2016-03-03 | Compositions and methods for treating ocular diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2984281T3 true ES2984281T3 (es) | 2024-10-29 |
Family
ID=56848617
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES16759492T Active ES2984281T3 (es) | 2015-03-03 | 2016-03-03 | Composiciones que comprenden un antagonista de la aldosterona para su uso en el tratamiento de ojos secos |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10350223B2 (https=) |
| EP (1) | EP3265103B1 (https=) |
| JP (1) | JP6861634B2 (https=) |
| ES (1) | ES2984281T3 (https=) |
| WO (1) | WO2016141182A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019140207A1 (en) * | 2018-01-11 | 2019-07-18 | Yee Richard W | Compositions and methods for treating ocular diseases |
| US12161752B2 (en) * | 2019-08-20 | 2024-12-10 | Vishwanath Padmanabhan | Compositions and methods for the treatment of anterior blepharitis and posterior blepharitis |
| WO2021191273A1 (en) | 2020-03-24 | 2021-09-30 | Hovione Scientia Limited | Compositions for use in treating meibomian gland dysfunction |
| CN113577022B (zh) * | 2021-05-18 | 2023-03-17 | 南京欣通瑞亿医药科技有限公司 | 一种氨苯砜类化合物混悬液及其制备方法和应用 |
Family Cites Families (41)
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| US3551554A (en) | 1968-08-16 | 1970-12-29 | Crown Zellerbach Corp | Enhancing tissue penetration of physiologically active agents with dmso |
| US3711602A (en) | 1970-10-30 | 1973-01-16 | Crown Zellerbach Corp | Compositions for topical application for enhancing tissue penetration of physiologically active agents with dmso |
| US4192802A (en) | 1976-06-09 | 1980-03-11 | Ciba-Geigy Corporation | Process for the manufacture of steroid carboxylic acid lactones |
| FI59534C (fi) | 1979-10-31 | 1981-09-10 | Orion Yhtymae Oy | Vaordmedel foer fraemjande av haorvaext och hindrande av mjaell |
| GR74635B (https=) | 1980-08-18 | 1984-06-29 | Merck & Co Inc | |
| USRE32112E (en) | 1981-05-26 | 1986-04-15 | Spironolactone-containing composition and use thereof | |
| IT1194185B (it) | 1983-04-01 | 1988-09-14 | Schiapparelli Farma | Composizione per il trattamento dell'acne |
| ES532317A0 (es) | 1983-05-16 | 1985-11-16 | Merck & Co Inc | Una composicion farmaceutica |
| FR2588755B3 (fr) | 1985-10-21 | 1988-01-22 | Aron Brunetiere Robert | Composition therapeutique a base de spironolactone destinee au traitement des alopecies androgenogenetiques |
| NZ226171A (en) | 1987-09-18 | 1990-06-26 | Ethicon Inc | Gel formulation containing polypeptide growth factor |
| EP0410348A1 (en) | 1989-07-26 | 1991-01-30 | G.D. Searle & Co. | Topical spironolactone composition |
| JPH05331066A (ja) | 1992-05-25 | 1993-12-14 | Toko Yakuhin Kogyo Kk | 尋常性ざ瘡治療用組成物 |
| MX9303557A (es) | 1992-08-06 | 1994-03-31 | Beta Pharm Co | Metodo para la administracion de un antiandrogeno, en particular, espironolactona, a traves de la piel. |
| WO1996040258A2 (en) | 1995-06-07 | 1996-12-19 | G.D. Searle & Co. | Spironolactone and angiotensin ii antagonist combination therapy for treatment of congestive heart failure |
| ATE343379T1 (de) | 1998-08-20 | 2006-11-15 | 3M Innovative Properties Co | Sprühverband und wirkstoffabgabesystem |
| AU5460800A (en) | 1999-06-02 | 2000-12-18 | Aviana Biopharm | Pharmaceutical transdermal compositions |
| EP1227804B1 (en) | 1999-11-09 | 2007-08-22 | Pharmacia Corporation | Use of eplerenone for treating restenosis |
| WO2003049745A1 (en) | 2001-12-12 | 2003-06-19 | Pharmacia Corporation | Method of treating ophthalmic disorders with epoxy-steroidal aldosterone receptor antagonists |
| PL371437A1 (en) | 2002-01-30 | 2005-06-13 | Pharmacia Corporation | Aldosterone receptor antagonist and alpha-adrenergic modulating agent combination therapy for prevention or treatment of pathogenic conditions |
| EP1509236A4 (en) | 2002-05-13 | 2008-07-30 | Children S Hospital Los Angele | TREATMENT AND PREVENTION OF ABNORMAL SCALING IN KELOIDS AND OTHER SKIN OR INTERNAL WOUNDS OR LESIONS |
| ATE411010T1 (de) | 2002-12-13 | 2008-10-15 | Jagotec Ag | Topische nanopartikel-spironolacton-formulierung |
| CL2004000574A1 (es) | 2003-03-21 | 2005-02-11 | Pharmacia Corp Sa Organizada B | Proceso para preparar un compuesto 17-espirolactona o la sal de lactona abierta por carbonilacion del correspondiente 17-alquenil o alquinil derivado, los intermediarios que se usan y su proceso de obtencion. |
| WO2006002022A2 (en) | 2004-06-15 | 2006-01-05 | Immusol Incorporated | Compositions and methods useful for the treatment of hyperglycemia |
| BRPI0516308A2 (pt) | 2004-10-04 | 2010-06-15 | Qlt Usa Inc | composição fluida, métodos de tratamento de uma doença ou disfunção, métodos de liberação local ou sistêmica de um agente biológico, implantes, método de formação de um implante, kit de agente biológico e usos de uma composição fluida |
| JP4969052B2 (ja) | 2005-03-31 | 2012-07-04 | 小林製薬株式会社 | 眼科用組成物 |
| US20100130580A1 (en) * | 2006-01-25 | 2010-05-27 | Aciex Therapeutics, Inc. | Formulations and Methods for Treating Dry Eye |
| GB0615064D0 (en) | 2006-07-28 | 2006-09-06 | Sinclair Pharmaceuticals Ltd | Medicament |
| US7879910B1 (en) | 2006-10-10 | 2011-02-01 | Jan Marini Skin Research, Inc. | Compositions and methods for promoting lush hair growth |
| US20100068301A1 (en) | 2006-11-30 | 2010-03-18 | Hutchinson John H | Compositions and treatments comprising 5-lipoxygenase-activating protein inhibitors and nitric oxide modulators |
| EP3574909B1 (en) | 2008-01-30 | 2026-03-04 | Imbed Biosciences, Inc. | Polyelectrolyte multilayer comprising silver for wound healing |
| US8318678B2 (en) | 2008-05-30 | 2012-11-27 | Jan Marini Skin Research | Cosmetic compositions |
| US20090325918A1 (en) | 2008-06-16 | 2009-12-31 | Somberg John C | Synthesis and separation of optically active isomers and cyclopropyl derivatives of spironolactone and their biological action |
| WO2010038234A1 (en) | 2008-10-02 | 2010-04-08 | Taro Pharmaceutical Industries Ltd. | Combination product of spironolactone and doxycycline |
| WO2010096558A1 (en) | 2009-02-18 | 2010-08-26 | Eyeon Particle Sciences Llc | Bi-functional co-polymer use for ophthalmic and other topical and local applications |
| CA2769041A1 (en) | 2009-07-18 | 2011-01-27 | Leuko Ophthalmic Technologies Limited | Methods material and systems for producing a contact lens and contact lenses produced using said methods material and systems |
| EP2977084B1 (en) | 2010-05-10 | 2017-07-05 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for the treatment of fluid accumulation in and/ or under the retina |
| JP6180930B2 (ja) | 2010-06-16 | 2017-08-16 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 創傷治癒過程における再上皮化を刺激するための方法及び組成物 |
| US20120252756A1 (en) * | 2010-06-25 | 2012-10-04 | Coffey Martin J | Pharmaceutical Compositions and Methods for Treating, Controlling, Ameliorating, or Reversing Conditions of the Eye |
| WO2012093117A1 (en) | 2011-01-03 | 2012-07-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of ocular inflammatory diseases |
| US9808529B2 (en) | 2012-05-18 | 2017-11-07 | Luoda Pharma Pty Ltd | Liquid formulation |
| WO2014202744A1 (en) | 2013-06-21 | 2014-12-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Pharmaceutical compositions for preventing glucocorticoid-induced corneal or skin thinning |
-
2016
- 2016-03-03 US US15/555,527 patent/US10350223B2/en active Active
- 2016-03-03 WO PCT/US2016/020683 patent/WO2016141182A1/en not_active Ceased
- 2016-03-03 EP EP16759492.8A patent/EP3265103B1/en active Active
- 2016-03-03 ES ES16759492T patent/ES2984281T3/es active Active
- 2016-03-03 JP JP2017545950A patent/JP6861634B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20180050049A1 (en) | 2018-02-22 |
| EP3265103A1 (en) | 2018-01-10 |
| EP3265103C0 (en) | 2024-07-24 |
| EP3265103A4 (en) | 2018-11-14 |
| EP3265103B1 (en) | 2024-07-24 |
| US10350223B2 (en) | 2019-07-16 |
| JP2018510855A (ja) | 2018-04-19 |
| WO2016141182A1 (en) | 2016-09-09 |
| JP6861634B2 (ja) | 2021-04-21 |
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