ES2980252T3 - Inhibidores de arginasa y sus métodos de uso - Google Patents
Inhibidores de arginasa y sus métodos de uso Download PDFInfo
- Publication number
- ES2980252T3 ES2980252T3 ES19758683T ES19758683T ES2980252T3 ES 2980252 T3 ES2980252 T3 ES 2980252T3 ES 19758683 T ES19758683 T ES 19758683T ES 19758683 T ES19758683 T ES 19758683T ES 2980252 T3 ES2980252 T3 ES 2980252T3
- Authority
- ES
- Spain
- Prior art keywords
- aza
- oxa
- hydroxy
- dodecan
- boraspiro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 title abstract description 14
- 102000004452 Arginase Human genes 0.000 title description 22
- 108700024123 Arginases Proteins 0.000 title description 22
- 239000003112 inhibitor Substances 0.000 title description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 43
- HMZBZPGFUGYYIH-UHIISALHSA-N (2S)-2-amino-N-[(3R,5R)-10-hydroxy-12-oxo-11-oxa-1-aza-10-boraspiro[4.7]dodecan-3-yl]-3-methylbutanamide Chemical compound N[C@H](C(=O)N[C@H]1CN[C@]2(C1)C(OB(CCCC2)O)=O)C(C)C HMZBZPGFUGYYIH-UHIISALHSA-N 0.000 claims abstract description 37
- 238000000634 powder X-ray diffraction Methods 0.000 claims description 55
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- MVHFGAWLHMAREF-IIYDPXPESA-N (3R,5R)-3-[(4S)-2,2-dimethyl-5-oxo-4-propan-2-ylimidazolidin-1-yl]-10-hydroxy-11-oxa-1-aza-10-boraspiro[4.7]dodecan-12-one Chemical compound OB1OC([C@]2(C[C@H](CN2)N2C(N[C@H](C2=O)C(C)C)(C)C)CCCC1)=O MVHFGAWLHMAREF-IIYDPXPESA-N 0.000 abstract description 69
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
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- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
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| US201862721113P | 2018-08-22 | 2018-08-22 | |
| PCT/EP2019/072341 WO2020038983A1 (en) | 2018-08-22 | 2019-08-21 | Arginase inhibitors and methods of use thereof |
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| ES2980252T3 true ES2980252T3 (es) | 2024-09-30 |
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| EP3810610A1 (en) | 2018-05-18 | 2021-04-28 | Incyte Corporation | Fused pyrimidine derivatives as a2a / a2b inhibitors |
| CN117304191A (zh) | 2018-07-05 | 2023-12-29 | 因赛特公司 | 作为a2a/a2b抑制剂的稠合吡嗪衍生物 |
| TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
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| EP4239652A4 (en) | 2020-12-25 | 2024-06-05 | Sumitomo Riko Company Limited | Electrically conductive composition, sheet-form flexible electrode using same, and method for producing said electrode |
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| AU2016281620B2 (en) * | 2015-06-23 | 2021-07-22 | Calithera Biosciences, Inc. | Compositions and methods for inhibiting arginase activity |
| US11291674B2 (en) * | 2016-11-08 | 2022-04-05 | Calithera Biosciences, Inc. | Arginase inhibitor combination therapies |
| WO2018119440A1 (en) | 2016-12-22 | 2018-06-28 | Calithera Biosciences, Inc. | Compositions and methods for inhibiting arginase activity |
| SG11202007739XA (en) | 2018-02-17 | 2020-09-29 | Astrazeneca Ab | Arginase inhibitors and methods of use thereof |
| US12215116B2 (en) | 2018-03-13 | 2025-02-04 | Merck Sharp & Dohme Llc | Arginase inhibitors and methods of use |
| WO2019205979A1 (zh) | 2018-04-27 | 2019-10-31 | 四川科伦博泰生物医药股份有限公司 | 非天然氨基酸类衍生物、包含其的药物组合物及其制备方法和用途 |
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2021
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