ES298011A1 - A new antibiotic ussamycin - Google Patents
A new antibiotic ussamycinInfo
- Publication number
- ES298011A1 ES298011A1 ES0298011A ES298011A ES298011A1 ES 298011 A1 ES298011 A1 ES 298011A1 ES 0298011 A ES0298011 A ES 0298011A ES 298011 A ES298011 A ES 298011A ES 298011 A1 ES298011 A1 ES 298011A1
- Authority
- ES
- Spain
- Prior art keywords
- ussamycin
- acid
- water
- aqueous
- antibiotic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
- C12R2001/56—Streptomyces lavendulae
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to an antibiotic ussamycin which is active against gram positive micro-organisms and tumours is basic forming salts with inorganic and organic acids soluble in methanol insoluble in acetone, ether, benzene, chloroform and petroleum ether hydrochloride is soluble in water light-yellow colour, stable at pH 3 to 8 on acid hydrolysis produces glycine, alanine, leucine, serine, aspartic acid, glutamic acid, arginine and lysine Rf value 0.74 in n-butanol, pyridine, acetic acid, water (15 : 10 : 3 : 12) no U.V. spectrum. Ussamycin is produced by cultivating streptomyces lavendulae NRRL 3119 (mutant) in an aqueous nutrient medium. It is isolated from the clarified broth by (A) adsorption on active carbon, activated earth or a weakly acidic ion exchanger. Elution is by means of aqueous acid or aqueous water-miscible organic solvents, e.g. aqueous methanol (B) precipitation as picrate of Reineckate. Purification is by adsorption or distribution chromatography or by counter-current distribution between two immiscible solvent phases, e.g. in sec-butanol-3% acetic acid. The crude antibiotic may be dissolved in water and precipitated with Reinecke salt. Specified salts are the hydrochloride, sulphate, phosphate, nitrate, acetate, propionate, valerate, palmitate, oleate, succinate, citrate or mandelate. Pharmaceutical preparations for human or veterinary use comprise ussamycin or a physiologically tolerable salt thereof and a carrier. Formulations may be tablets, dragees, powders, solutions, suspensions, emulsions, suppositories and injections. The antibiotic may be added to an animal feed and may be used as a disinfectant or preservative.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH390663 | 1963-03-27 | ||
CH516263 | 1963-04-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES298011A1 true ES298011A1 (en) | 1964-12-01 |
Family
ID=25694139
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES0298011A Expired ES298011A1 (en) | 1963-03-27 | 1964-03-25 | A new antibiotic ussamycin |
Country Status (6)
Country | Link |
---|---|
BE (1) | BE645730A (en) |
DE (1) | DE1208449B (en) |
ES (1) | ES298011A1 (en) |
FR (1) | FR3429M (en) |
GB (1) | GB1060444A (en) |
NL (1) | NL6403317A (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5937952B2 (en) * | 1977-09-12 | 1984-09-12 | 正 新井 | Antibiotic saframycin A, B, C, D, E and its manufacturing method |
US5221625A (en) * | 1992-01-10 | 1993-06-22 | Merck & Co., Inc. | Cyclcic FR-900520 microbial biotransformation agent |
US5290689A (en) * | 1992-09-28 | 1994-03-01 | Merck & Co., Inc. | New cyclic FR-900520 microbial biotransformation agent |
US5268282A (en) * | 1992-09-28 | 1993-12-07 | Merck & Co., Inc. | Cyclic FR-900520 microbial biotransformation agent |
US5268281A (en) * | 1992-09-28 | 1993-12-07 | Merck & Co., Inc. | Cyclic FR-900520 microbial biotransformation agent |
US5283183A (en) * | 1992-09-28 | 1994-02-01 | Merck & Co., Inc. | Cyclic FR-900520 microbial biotransformation agent |
-
1964
- 1964-03-20 DE DEC32458A patent/DE1208449B/en active Pending
- 1964-03-24 GB GB12376/64A patent/GB1060444A/en not_active Expired
- 1964-03-25 ES ES0298011A patent/ES298011A1/en not_active Expired
- 1964-03-26 NL NL6403317A patent/NL6403317A/xx unknown
- 1964-03-26 BE BE645730A patent/BE645730A/xx unknown
- 1964-05-29 FR FR976291A patent/FR3429M/en active Active
Also Published As
Publication number | Publication date |
---|---|
BE645730A (en) | 1964-09-28 |
NL6403317A (en) | 1964-09-28 |
FR3429M (en) | 1965-07-12 |
DE1208449B (en) | 1966-01-05 |
GB1060444A (en) | 1967-03-01 |
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