ES298011A1 - A new antibiotic ussamycin - Google Patents

A new antibiotic ussamycin

Info

Publication number
ES298011A1
ES298011A1 ES0298011A ES298011A ES298011A1 ES 298011 A1 ES298011 A1 ES 298011A1 ES 0298011 A ES0298011 A ES 0298011A ES 298011 A ES298011 A ES 298011A ES 298011 A1 ES298011 A1 ES 298011A1
Authority
ES
Spain
Prior art keywords
ussamycin
acid
water
aqueous
antibiotic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0298011A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES298011A1 publication Critical patent/ES298011A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • C12R2001/56—Streptomyces lavendulae

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to an antibiotic ussamycin which is active against gram positive micro-organisms and tumours is basic forming salts with inorganic and organic acids soluble in methanol insoluble in acetone, ether, benzene, chloroform and petroleum ether hydrochloride is soluble in water light-yellow colour, stable at pH 3 to 8 on acid hydrolysis produces glycine, alanine, leucine, serine, aspartic acid, glutamic acid, arginine and lysine Rf value 0.74 in n-butanol, pyridine, acetic acid, water (15 : 10 : 3 : 12) no U.V. spectrum. Ussamycin is produced by cultivating streptomyces lavendulae NRRL 3119 (mutant) in an aqueous nutrient medium. It is isolated from the clarified broth by (A) adsorption on active carbon, activated earth or a weakly acidic ion exchanger. Elution is by means of aqueous acid or aqueous water-miscible organic solvents, e.g. aqueous methanol (B) precipitation as picrate of Reineckate. Purification is by adsorption or distribution chromatography or by counter-current distribution between two immiscible solvent phases, e.g. in sec-butanol-3% acetic acid. The crude antibiotic may be dissolved in water and precipitated with Reinecke salt. Specified salts are the hydrochloride, sulphate, phosphate, nitrate, acetate, propionate, valerate, palmitate, oleate, succinate, citrate or mandelate. Pharmaceutical preparations for human or veterinary use comprise ussamycin or a physiologically tolerable salt thereof and a carrier. Formulations may be tablets, dragees, powders, solutions, suspensions, emulsions, suppositories and injections. The antibiotic may be added to an animal feed and may be used as a disinfectant or preservative.
ES0298011A 1963-03-27 1964-03-25 A new antibiotic ussamycin Expired ES298011A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH390663 1963-03-27
CH516263 1963-04-24

Publications (1)

Publication Number Publication Date
ES298011A1 true ES298011A1 (en) 1964-12-01

Family

ID=25694139

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0298011A Expired ES298011A1 (en) 1963-03-27 1964-03-25 A new antibiotic ussamycin

Country Status (6)

Country Link
BE (1) BE645730A (en)
DE (1) DE1208449B (en)
ES (1) ES298011A1 (en)
FR (1) FR3429M (en)
GB (1) GB1060444A (en)
NL (1) NL6403317A (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5937952B2 (en) * 1977-09-12 1984-09-12 正 新井 Antibiotic saframycin A, B, C, D, E and its manufacturing method
US5221625A (en) * 1992-01-10 1993-06-22 Merck & Co., Inc. Cyclcic FR-900520 microbial biotransformation agent
US5290689A (en) * 1992-09-28 1994-03-01 Merck & Co., Inc. New cyclic FR-900520 microbial biotransformation agent
US5268282A (en) * 1992-09-28 1993-12-07 Merck & Co., Inc. Cyclic FR-900520 microbial biotransformation agent
US5268281A (en) * 1992-09-28 1993-12-07 Merck & Co., Inc. Cyclic FR-900520 microbial biotransformation agent
US5283183A (en) * 1992-09-28 1994-02-01 Merck & Co., Inc. Cyclic FR-900520 microbial biotransformation agent

Also Published As

Publication number Publication date
BE645730A (en) 1964-09-28
NL6403317A (en) 1964-09-28
FR3429M (en) 1965-07-12
DE1208449B (en) 1966-01-05
GB1060444A (en) 1967-03-01

Similar Documents

Publication Publication Date Title
ES298011A1 (en) A new antibiotic ussamycin
SE322191B (en)
GB877732A (en) The antibiotic rifomycin, its components and methods of preparing same
Thompson et al. Stendomycin: a new antifungal antibiotic
GB901830A (en) A new antibiotic danubomycin and a process for its manufacture
Lambein et al. New isoxazolinone amino acids from Lathyrus odoratus seedlings
Haskell et al. Succinimycin, a new iron-containing antibiotic
GB1126214A (en) Antiamoebin, a new antiprotozoal and anthelmintic antibiotic, and a method of producing the same
GB1470407A (en) Antibiotic substances
SE328254B (en)
GB1226494A (en)
GB1292010A (en) A new antibiotic, its production and its use
ES355613A1 (en) Novel antibiotics of agricultural fungicides, polyoxins j, k and l: and process for preparing the same
GB1388878A (en) Antibiotics process for their production and use in ruminant feed
GB1159970A (en) The Antibiotic Steffisburgensimycin
GB1113501A (en) Antibiotic ra-6950b and method of production
ES341402A1 (en) Antibiotics of agricultural fungicides,polyoxins d,e,f,g and h
GB893880A (en) A new antibiotic a 9578 and pharmaceutical compositions containing same
GB1280091A (en) Antibiotics yl 704
GB1226665A (en)
GB1107112A (en) Antibiotic josamycin and processes for the production thereof
GB1150476A (en) The Antibiotic Amethobottromycin
GB1356723A (en) Antibiotic sf-1293 substance and its production and uses
GB1216667A (en) The antibiotic diumycin
GB876096A (en) A new antibiotic, grisonomycin, and process for its manufacture